<abstract xmlns="http://www.w3.org/1999/xhtml"><bold><italic>Background</italic></bold>. Oxidative stress may play an important role in rheumatoid arthritis (RA) etiopathogenesis. The thiol group is a very strong antioxidant. In this study, we aimed to investigate the presence of oxidative stress in patients with RA by evaluating thiol/disulfide homeostasis.<bold><italic>Material and methods</italic></bold>. A total of 50 female RA patients and 50 healthy female controls were included in this study. Thiol and disulfide values were calculated utilizing novel methods.<bold><italic>Results</italic></bold>. Native thiol (p &lt; 0.001) and total thiol (p &lt; 0.001) levels of RA patients were significantly lower compared to values in the control group. However, the disulfide (p &lt; 0.001) levels of RA patients were strongly higher than in healthy individuals. A negative correlation was found between thiol and disease activity score-28 among the patients, whereas a positive correlation was found between disulfide and disease activity score-28 among the patients.<bold><italic>Conclusion</italic></bold>. We found that the thiol–disulfide rate deteriorated in RA patients, with the proportion of disulfide increasing. There is a strong correlation between the decrease in thiol levels, increase in disulfide levels and the disease activity scores.</abstract>

Background. Oxidative stress may play an important role in rheumatoid arthritis (RA) etiopathogenesis. The thiol group is a very strong antioxidant. In this study, we aimed to investigate the presence of oxidative stress in patients with RA by evaluating thiol/disulfide homeostasis.Material and methods. A total of 50 female RA patients and 50 healthy female controls were included in this study. Thiol and disulfide values were calculated utilizing novel methods.Results. Native thiol (p < 0.001) and total thiol (p < 0.001) levels of RA patients were significantly lower compared to values in the control group. However, the disulfide (p < 0.001) levels of RA patients were strongly higher than in healthy individuals. A negative correlation was found between thiol and disease activity score-28 among the patients, whereas a positive correlation was found between disulfide and disease activity score-28 among the patients.Conclusion. We found that the thiol–disulfide rate deteriorated in RA patients, with the proportion of disulfide increasing. There is a strong correlation between the decrease in thiol levels, increase in disulfide levels and the disease activity scores.

Thiol/Disulfide homeostasis in patients with rheumatoid arthritis

Department of Biochemistry, Malatya Education and Research Hospital

Department of Physical Medicine and Rehabilitation, Malatya Education and Research Hospital

Division of Rheumatology, Department of Internal Medicine, Numune Education and Research Hospital

Department of Physical Medicine and Rehabilitation, Malatya Park Private Hospital

Division of Rheumatology, Department of Internal Medicine, Diskapi Yildirim Beyazit Training and Research Hospital

Department of Internal Medicine, Camlica Erdem Hospital

Department of Clinical Biochemistry, Faculty of Medicine

Romanian Journal of Internal Medicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

{"article-title":"Thiol/Disulfide homeostasis in patients with rheumatoid arthritis"}

Background. Oxidative stress may play an important role in rheumatoid arthritis (RA) etiopathogenesis. The thiol group is a very strong antioxidant. In this...

Thiol/Disulfide homeostasis in patients with rheumatoid arthritis

Online veröffentlicht: 28. März 2019

Seitenbereich: 30 - 36

Eingereicht: 25. Juli 2018

DOI: https://doi.org/10.2478/rjim-2018-0025

Schlüsselwörter
Rheumatoid arthritis, thiol, disulfide, thiol/disulfide homeostasis, oxidative stress

© 2019 Ayca Tuzcu et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Thiol/Disulfide homeostasis in patients with rheumatoid arthritis

Online veröffentlicht: 28. März 2019

Seitenbereich: 30 - 36

Eingereicht: 25. Juli 2018

DOI: https://doi.org/10.2478/rjim-2018-0025

SchlüsselwörterRheumatoid arthritis, thiol, disulfide, thiol/disulfide homeostasis, oxidative stress

© 2019 Ayca Tuzcu et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Schlüsselwörter
Rheumatoid arthritis, thiol, disulfide, thiol/disulfide homeostasis, oxidative stress