<abstract xmlns="http://www.w3.org/1999/xhtml">Stroke is defined as a focal or at times global neurological impairment of sudden onset and presumed vascular origin. 85% of strokes are due to cerebral ischemia and the other 15% to primary intracerebral hemorrhage.Ischemic stroke (IS) is characterized by complete or partial obstruction of a vessel in the brain, resulting in lack of blood supply and death of brain tissue. The most common causes of IS are atherosclerosis, cardioembolism and small-vessel disease (lacunar stroke). Genetic factors play important role. Incidence rates for IS in the 15- to 45-year age range are ≈10 per 100,000 person years.Hemorrhagic stroke (HS) is the least treatable and the most fatal form of cerebrovascular disease. Genetic mechanisms play a role in its development. Occurrence depends on many risk factors, including hypertension, heavy alcohol intake and anticoagulant treatment. According to the World Health Organization, 15 million people suffer stroke worldwide each year. The overall incidence of spontaneous HS worldwide is 24.6 per 100,000 person years. Strokes are the third most common cause of death and the most common cause of disability in developed countries.This Utility Gene Test was developed on the basis of an analysis of the literature and existing diagnostic protocols. It is useful for confirming diagnosis, as well as for differential diagnosis, couple risk assessment and access to clinical trials.</abstract>

Stroke is defined as a focal or at times global neurological impairment of sudden onset and presumed vascular origin. 85% of strokes are due to cerebral ischemia and the other 15% to primary intracerebral hemorrhage.Ischemic stroke (IS) is characterized by complete or partial obstruction of a vessel in the brain, resulting in lack of blood supply and death of brain tissue. The most common causes of IS are atherosclerosis, cardioembolism and small-vessel disease (lacunar stroke). Genetic factors play important role. Incidence rates for IS in the 15- to 45-year age range are ≈10 per 100,000 person years.Hemorrhagic stroke (HS) is the least treatable and the most fatal form of cerebrovascular disease. Genetic mechanisms play a role in its development. Occurrence depends on many risk factors, including hypertension, heavy alcohol intake and anticoagulant treatment. According to the World Health Organization, 15 million people suffer stroke worldwide each year. The overall incidence of spontaneous HS worldwide is 24.6 per 100,000 person years. Strokes are the third most common cause of death and the most common cause of disability in developed countries.This Utility Gene Test was developed on the basis of an analysis of the literature and existing diagnostic protocols. It is useful for confirming diagnosis, as well as for differential diagnosis, couple risk assessment and access to clinical trials.

Genetic testing for Mendelian stroke due to cerebrovascular anomalies and other syndromes

U.O.C. di Neurologia, A.S.S.T. della Franciacorta

The EuroBiotech Journal

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Stroke is defined as a focal or at times global neurological impairment of sudden onset and presumed vascular origin. 85% of strokes are due to cerebral...

Clinical management	Utility
Confirmation of clinical diagnosis	Yes
Differential diagnosis	Yes
Couple risk assessment	Yes
Availability of clinical trials can be checked on-line at htps://clinicaltrials.gov/

Genetic testing for Mendelian stroke due to cerebrovascular anomalies and other syndromes

Article Category: Technical Report

Online veröffentlicht: 19. Sept. 2018

Seitenbereich: 78 - 82

DOI: https://doi.org/10.2478/ebtj-2018-0045

Schlüsselwörter
Ischemic stroke, hemorrhagic stroke, EBTNA UTILITY GENE TEST

© 2018 Paolo Enrico Maltese, Yeltay Rakhmanov, Alice Bruson, Lorenzo Lorusso, Matteo Bertelli, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

j.ebtj-2018-0045.tab.001.w2aab3b7c22b1b6b1ab1c10b1Aa

Genetic testing for Mendelian stroke due to cerebrovascular anomalies and other syndromes

Article Category: Technical Report

Online veröffentlicht: 19. Sept. 2018

Seitenbereich: 78 - 82

DOI: https://doi.org/10.2478/ebtj-2018-0045

SchlüsselwörterIschemic stroke, hemorrhagic stroke, EBTNA UTILITY GENE TEST

© 2018 Paolo Enrico Maltese, Yeltay Rakhmanov, Alice Bruson, Lorenzo Lorusso, Matteo Bertelli, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

j.ebtj-2018-0045.tab.001.w2aab3b7c22b1b6b1ab1c10b1Aa

Schlüsselwörter
Ischemic stroke, hemorrhagic stroke, EBTNA UTILITY GENE TEST