<abstract xmlns="http://www.w3.org/1999/xhtml"><p>Transfer of nicotine to mainstream smoke was measured for Reference cigarettes made with the addition of 20 -40 mg of seven different nicotine salts, <italic>d</italic>- and <italic>l</italic>-nicotine and <italic>N’</italic>-formylnornicotine. Regression analysis of the nicotine yields from these cigarettes as a function of the nicotine content of the tobacco rods indicated an average nicotine transfer efficiency (17.5%), similar to that found for a separate series of cigarettes made with single-grade tobacco materials (16.2%). Analysis of the enantiomeric purity of the smoke nicotine from the cigarettes made with added nicotine salts and neat nicotine showed no evidence of conversion between <italic>l-</italic> and <italic>d</italic>-nicotine during the smoking process. The cigarette made with added <italic>N’</italic>-formylnornicotine showed no evidence of additional nicotine transfer attributable to reduction of this compound to nicotine. A third series of cigarettes were made with varying levels of <italic>d-</italic> and <italic>l-</italic>nicotine added to a tobacco blend and to reconstituted tobacco to further investigate transfer efficiency of the enantiomers. Regression analysis indicated no statistically significant difference between transfer efficiencies of <italic>d</italic>- and <italic>l</italic>-nicotine. These results suggest that nicotine salts and <italic>d</italic>- and <italic>l</italic>-nicotine transfer to smoke at the same efficiency. However, transfer efficiency of either compound was lower when applied to reconstituted tobacco (9.7%) than when applied to the Reference tobacco blend (15.3%). The thermal stabilities of nicotine salts have little bearing on efficiency of transfer to smoke or on racemization between <italic>d</italic>- and <italic>l</italic>-nicotine. Formation of d-nicotine in mainstream smoke via reduction of <italic>N’</italic>-formylnornicotine does not appear to occur.</p></abstract>

Transfer of nicotine to mainstream smoke was measured for Reference cigarettes made with the addition of 20 -40 mg of seven different nicotine salts, d- and l-nicotine and N’-formylnornicotine. Regression analysis of the nicotine yields from these cigarettes as a function of the nicotine content of the tobacco rods indicated an average nicotine transfer efficiency (17.5%), similar to that found for a separate series of cigarettes made with single-grade tobacco materials (16.2%). Analysis of the enantiomeric purity of the smoke nicotine from the cigarettes made with added nicotine salts and neat nicotine showed no evidence of conversion between l- and d-nicotine during the smoking process. The cigarette made with added N’-formylnornicotine showed no evidence of additional nicotine transfer attributable to reduction of this compound to nicotine. A third series of cigarettes were made with varying levels of d- and l-nicotine added to a tobacco blend and to reconstituted tobacco to further investigate transfer efficiency of the enantiomers. Regression analysis indicated no statistically significant difference between transfer efficiencies of d- and l-nicotine. These results suggest that nicotine salts and d- and l-nicotine transfer to smoke at the same efficiency. However, transfer efficiency of either compound was lower when applied to reconstituted tobacco (9.7%) than when applied to the Reference tobacco blend (15.3%). The thermal stabilities of nicotine salts have little bearing on efficiency of transfer to smoke or on racemization between d- and l-nicotine. Formation of d-nicotine in mainstream smoke via reduction of N’-formylnornicotine does not appear to occur.

The Transfer of Nicotine from Nicotine Salts to Mainstream Smoke

R.J. Reynolds Tobacco Company, Winston-Salem, NC, USA

Contributions to Tobacco & Nicotine Research

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"The Transfer of Nicotine from Nicotine Salts to Mainstream Smoke"}

Transfer of nicotine to mainstream smoke was measured for Reference cigarettes made with the addition of 20 -40 mg of seven different nicotine salts, d- and...

The Transfer of Nicotine from Nicotine Salts to Mainstream Smoke

Online veröffentlicht: 30. Dez. 2014

Seitenbereich: 141 - 158

Eingereicht: 30. März 2000

Akzeptiert: 23. Aug. 2000

DOI: https://doi.org/10.2478/cttr-2013-0702

© 2014 Beiträge zur Tabakforschung International

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.