<abstract xmlns="http://www.w3.org/1999/xhtml"><p>This paper evaluates and compares the properties of directly compressible tabletting materials and matrix tablets containing a combination of α-lactose monohydrate and microcrystalline cellulose in the 3:1 ratio in a physical mixture and in a coprocessed dry binder. Tested parameters include flow properties, compressibility, compactibility and the rate of drug release from tablets. Compressibility is evaluated by means of the energy profile of the compression process. Compactibility is evaluated by means of the tensile strength of the tablets. Dissolution testing is done using the rotating basket method. Dissolution profiles are evaluated by non-linear regression analysis.</p><p>Total energy of compression and plasticity values were higher in tabletting materials with the coprocessed dry binder. Increasing additions of polyvinyl alcohol decreased the values of total energy of compression, plasticity, tensile strength of tablets and drug release rate. Dissolution behaviour of tablets, which contained the physical mixture or coprocessed dry binder and the same amount of polyvinyl alcohol, was comparable.</p></abstract>

This paper evaluates and compares the properties of directly compressible tabletting materials and matrix tablets containing a combination of α-lactose monohydrate and microcrystalline cellulose in the 3:1 ratio in a physical mixture and in a coprocessed dry binder. Tested parameters include flow properties, compressibility, compactibility and the rate of drug release from tablets. Compressibility is evaluated by means of the energy profile of the compression process. Compactibility is evaluated by means of the tensile strength of the tablets. Dissolution testing is done using the rotating basket method. Dissolution profiles are evaluated by non-linear regression analysis.Total energy of compression and plasticity values were higher in tabletting materials with the coprocessed dry binder. Increasing additions of polyvinyl alcohol decreased the values of total energy of compression, plasticity, tensile strength of tablets and drug release rate. Dissolution behaviour of tablets, which contained the physical mixture or coprocessed dry binder and the same amount of polyvinyl alcohol, was comparable.

Comparative evaluation of the use of dry binders in a physical mixture or as a coprocessed dry binder in matrix tablets with extended drug release

Department of Physical Chemistry, Faculty of Chemical Technology

Department of Analytical Chemistry, Faculty of Chemical Technology

Acta Pharmaceutica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

This paper evaluates and compares the properties of directly compressible tabletting materials and matrix tablets containing a combination of α-lactose...

Comparative evaluation of the use of dry binders in a physical mixture or as a coprocessed dry binder in matrix tablets with extended drug release

Online veröffentlicht: 04. Juli 2018

Seitenbereich: 295 - 311

Akzeptiert: 05. Apr. 2018

DOI: https://doi.org/10.2478/acph-2018-0030

Schlüsselwörter
coprocessed dry binder, matrix tablets, polyvinyl alcohol, energy profile of compression, tensile strength of tablets, dissolution testing

© 2018 Alena Komersová et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Comparative evaluation of the use of dry binders in a physical mixture or as a coprocessed dry binder in matrix tablets with extended drug release

Online veröffentlicht: 04. Juli 2018

Seitenbereich: 295 - 311

Akzeptiert: 05. Apr. 2018

DOI: https://doi.org/10.2478/acph-2018-0030

Schlüsselwörtercoprocessed dry binder, matrix tablets, polyvinyl alcohol, energy profile of compression, tensile strength of tablets, dissolution testing

© 2018 Alena Komersová et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Schlüsselwörter
coprocessed dry binder, matrix tablets, polyvinyl alcohol, energy profile of compression, tensile strength of tablets, dissolution testing