<abstract xmlns="http://www.w3.org/1999/xhtml"><p> The aim of the present study was to evaluate chitosan as a vaginal mucoadhesive gel base for econazole nitrate and miconazole nitrate. To this aim, different types of chitosan with different molecular masses and viscosity properties [low molecular mass chitosan (viscosity: 20,000 mPa s), medium molecular mass chitosan (viscosity: 200,000 mPa s), high molecular mass chitosan (viscosity: 800,000 mPa s)] have been used. First, rheological studies were conducted on chitosan gels. Mechanical, syringeability and mucoadhesive properties of chitosan gels were determined. Release profiles of econazole nitrate and miconazole nitrate from chitosan gels were obtained and evaluated kinetically. In addition, anticandidal activities of formulations were determined. Finally, vaginal retention of chitosan gels in rats was evaluated by in vivo distribution studies. Based on the results, it can be concluded that gels prepared with medium molecular mass chitosan might be effectively used for different antifungal agents in the treatment of vaginal candidiosis, since it has high mucoadhesiveness, suitable mechanical and release properties with good vaginal retention</p></abstract>

The aim of the present study was to evaluate chitosan as a vaginal mucoadhesive gel base for econazole nitrate and miconazole nitrate. To this aim, different types of chitosan with different molecular masses and viscosity properties [low molecular mass chitosan (viscosity: 20,000 mPa s), medium molecular mass chitosan (viscosity: 200,000 mPa s), high molecular mass chitosan (viscosity: 800,000 mPa s)] have been used. First, rheological studies were conducted on chitosan gels. Mechanical, syringeability and mucoadhesive properties of chitosan gels were determined. Release profiles of econazole nitrate and miconazole nitrate from chitosan gels were obtained and evaluated kinetically. In addition, anticandidal activities of formulations were determined. Finally, vaginal retention of chitosan gels in rats was evaluated by in vivo distribution studies. Based on the results, it can be concluded that gels prepared with medium molecular mass chitosan might be effectively used for different antifungal agents in the treatment of vaginal candidiosis, since it has high mucoadhesiveness, suitable mechanical and release properties with good vaginal retention

Evaluation of chitosan based vaginal bioadhesive gel formulations for antifungal drugs

Ege University, Faculty of Pharmacy Department of Pharmaceutical Technology 35100 Bornova, İzmir, Turkey

Ege University, Faculty of Pharmacy Department of Microbiology 35100 Bornova, İzmir, Turkey

Acta Pharmaceutica

This article is distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

The aim of the present study was to evaluate chitosan as a vaginal mucoadhesive gel base for econazole nitrate and miconazole nitrate. To this aim, different...

Evaluation of chitosan based vaginal bioadhesive gel formulations for antifungal drugs

Online veröffentlicht: 06. Juni 2014

Seitenbereich: 139 - 156

Akzeptiert: 19. Dez. 2013

DOI: https://doi.org/10.2478/acph-2014-0013

Schlüsselwörter
chitosan, vaginal gel, mucoadhesion, econazole nitrate, miconazole nitrate, vaginal retention

© by Zeynep Ay Şenyiğit

This article is distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Evaluation of chitosan based vaginal bioadhesive gel formulations for antifungal drugs

Online veröffentlicht: 06. Juni 2014

Seitenbereich: 139 - 156

Akzeptiert: 19. Dez. 2013

DOI: https://doi.org/10.2478/acph-2014-0013

Schlüsselwörterchitosan, vaginal gel, mucoadhesion, econazole nitrate, miconazole nitrate, vaginal retention

© by Zeynep Ay Şenyiğit

This article is distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Schlüsselwörter
chitosan, vaginal gel, mucoadhesion, econazole nitrate, miconazole nitrate, vaginal retention