Clinical-pathologic features | Patients with visible fluorescence (n=42) | Patients with no visible fluorescence (n=18) | P value | χ2, Fisher, or Student t test |
---|---|---|---|---|
Age (years) | ||||
Average ± SD | 62.4 ± 16.4 | 56.7 ± 12.5 | 0.16 | - |
IDH1 mutation | <0.001 | 23.57 | ||
Positive | 2 | 11 | ||
Negative | 40 | 7 | ||
1p19q LOH | 0.003 | 10.22 | ||
Positive | 5 | 9 | ||
Negative | 37 | 9 | ||
MGMT methylation | 0.05 | 4.35 | ||
Positive | 18 | 13 | ||
Negative | 24 | 5 | ||
MIB1 LI (%) | ||||
Average ± SD | 38.5 ± 20.7 | 20.2 ± 22.8 | 0.007 | - |
Tumor margin | 0.046 | 4.88 | ||
Irregular | 27 | 6 | ||
Smooth | 15 | 12 | ||
T2 Heterogeneity | 0.021 | 6.48 | ||
Homo | 2 | 5 | ||
Hetero | 40 | 13 | ||
Contrast enhancement | 0.002 | 11.71 | ||
Positive | 41 | 12 | ||
Negative | 1 | 6 |
Characteristics | No. of Patients (%) |
---|---|
Number of patients | 60 (100) |
Sex | |
Male | 35 (58.3) |
Female | 25 (41.7) |
Age (yrs) | |
Average ± SD | 60.7 ± 15.4 |
Median | 62.5 |
Range | 6 - 80 |
Tumor grades and subtypes (WHO 2007) | |
Astrocytoma | 2 (3.3) |
Oligoastrocytoma | 3 (5.0) |
Oligodendroglioma | 3 (5.0) |
Anaplastic astrocytoma | 2 (3.3) |
Anaplastic oligoastrocytoma | 3 (5.0) |
Anaplastic oligodendroglioma | 12 (20.0) |
Localization | |
Frontal | 22 (36.7) |
Fronto-temporal | 2 (3.3) |
Temporal | 9 (15.0) |
Temporo-parietal | 5 (8.3) |
Temporal & insular | 2 (3.3) |
Parietal | 4 (6.7) |
Parieto-occipital | 2 (3.3) |
Occipital | 0 (0) |
Insular | 4 (6.7) |
Central | 8 (13.3) |
Cerebellar | 2 (3.3) |
Tumor Status | |
Primary | 54 (90.0) |
Recurrence | 6 (10.0) |
Factor | P Value | Odds ratio | 95% confidence interval |
---|---|---|---|
IDH1 wild type | 0.009 | 19.238 | 1.39, 175.39 |
1p19q LOH | 0.198 | 0.301 | 0.05, 1.87 |
MIB-1 labeling index | 0.157 | 1.033 | 0.99, 1.08 |
Tumor margin | 0.743 | 0.720 | 0.10, 5.15 |
T2 heterogeneity | 0.470 | 2.763 | 0.18, 43.44 |
Contrast enhancement | 0.345 | 4.107 | 0.22, 77.32 |
5-ALA fluorescence | WHO grade II | WHO grade III | WHO grade IV |
---|---|---|---|
Positive | 2/8 (25 %) | 9/17 (53 %) | 31/35 (89%) |
Negative | 6/8 (75 %) | 8/17 (47 %) | 4/35 (11%) |