<abstract xmlns="http://www.w3.org/1999/xhtml"><bold>Introduction</bold>: <italic>Cupriavidus pauculus</italic> is a rarely isolated non-fermentative, aerobic bacillus, which occasionally causes severe human infections, especially in immunocompromised patients. Strains have been isolated from various clinical and environmental sources.<bold>Case presentation</bold>: A 67-year-old man was admitted to the Intensive Care Unit with acute respiratory failure. The patient was diagnosed with bilateral pneumonia, pulmonary sepsis and underwent invasive mechanical ventilation. Examination revealed diminished bilateral vesicular breath sounds, fever, intense yellow tracheal secretions, a respiratory rate of 24/minute, a heart rate of 123/minute, and blood pressure of 75/55 mmHg. Vasoactive treatment was initiated. Investigations revealed elevated lactate and C-reactive protein levels. A chest X-ray showed bilateral infiltration. Parenteral ciprofloxacin and ceftriaxone were administered. Tracheal aspirate culture and blood culture showed bacterial growth of Cupriavidus pauculus. Colistin was added to the treatment. There was a poor clinical response despite repeated blood culture showing negative results. The diagnosis of multiple organ dysfunction syndrome (MODS) caused by C. pauculus was made. The patient died eleven days after admission.<bold>Conclusions</bold>: Clinical improvement cannot always be expected in spite of targeted antibiotic therapy. This pathogen should be considered responsible for infections that usually develop in immunocompromised patients.</abstract>

Introduction: Cupriavidus pauculus is a rarely isolated non-fermentative, aerobic bacillus, which occasionally causes severe human infections, especially in immunocompromised patients. Strains have been isolated from various clinical and environmental sources.Case presentation: A 67-year-old man was admitted to the Intensive Care Unit with acute respiratory failure. The patient was diagnosed with bilateral pneumonia, pulmonary sepsis and underwent invasive mechanical ventilation. Examination revealed diminished bilateral vesicular breath sounds, fever, intense yellow tracheal secretions, a respiratory rate of 24/minute, a heart rate of 123/minute, and blood pressure of 75/55 mmHg. Vasoactive treatment was initiated. Investigations revealed elevated lactate and C-reactive protein levels. A chest X-ray showed bilateral infiltration. Parenteral ciprofloxacin and ceftriaxone were administered. Tracheal aspirate culture and blood culture showed bacterial growth of Cupriavidus pauculus. Colistin was added to the treatment. There was a poor clinical response despite repeated blood culture showing negative results. The diagnosis of multiple organ dysfunction syndrome (MODS) caused by C. pauculus was made. The patient died eleven days after admission.Conclusions: Clinical improvement cannot always be expected in spite of targeted antibiotic therapy. This pathogen should be considered responsible for infections that usually develop in immunocompromised patients.

A Fatal Case of Community Acquired <italic>Cupriavidus Pauculus</italic> Pneumonia

Discipline of Intensive Care, University of Medicine and Pharmacy Tîrgu Mureş,

Discipline of Infectious Diseases, University of Medicine and Pharmacy Tîrgu Mureş,

The Journal of Critical Care Medicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

A Fatal Case of Community Acquired  Pneumonia

Introduction: Cupriavidus pauculus is a rarely isolated non-fermentative, aerobic bacillus, which occasionally causes severe human infections, especially in...

A Fatal Case of Community Acquired Cupriavidus Pauculus Pneumonia

Online veröffentlicht: 08. Nov. 2016

Seitenbereich: 201 - 204

Eingereicht: 14. Aug. 2016

Akzeptiert: 20. Sept. 2016

DOI: https://doi.org/10.1515/jccm-2016-0027

Schlüsselwörter
sepsis, pneumonia

© 2016 Emoke Almasy et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

A Fatal Case of Community Acquired Cupriavidus Pauculus Pneumonia

Online veröffentlicht: 08. Nov. 2016

Seitenbereich: 201 - 204

Eingereicht: 14. Aug. 2016

Akzeptiert: 20. Sept. 2016

DOI: https://doi.org/10.1515/jccm-2016-0027

Schlüsselwörtersepsis, pneumonia

© 2016 Emoke Almasy et al., published by De Gruyter Open

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Schlüsselwörter
sepsis, pneumonia