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Stump M, Mukohda M, Hu C, Sigmund CD. PPARγ regulation in hypertension and metabolic syndrome. Curr Hypertens Rep. 2015; 17(12): 1-9.StumpMMukohdaMHuCSigmundCD.PPARγ regulation in hypertension and metabolic syndrome2015171219Search in Google Scholar
Feige JN, Gelman L, Michalik L, Desvergne B, Wahli W. From molecular action to physiological outputs: Peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions. Prog Lipid Res. 2006; 45(2): 120-159.FeigeJNGelmanLMichalikLDesvergneBWahliW.From molecular action to physiological outputs: Peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions2006452120159Search in Google Scholar
Buzzetti R, Petrone A, Ribaudo MC, Alemanno I, Zavarella S, Mein CA, et al. The common PPAR-γ2 Pro12 Ala variant is associated with greater insulin sensitivity. Eur J Hum Genet. 2004; 12(12): 1050-1054.BuzzettiRPetroneARibaudoMCAlemannoIZavarellaSMeinCAThe common PPAR-γ2 Pro12 Ala variant is associated with greater insulin sensitivity2004121210501054Search in Google Scholar
Kubota N, Terauchi Y, Miki H, Tamemoto H, Yamauchi T, Komeda K, et al. PPARγ mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance. Mol Cell. 1999; 4(4): 597-609.KubotaNTerauchiYMikiHTamemotoHYamauchiTKomedaKPPARγ mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance199944597609Search in Google Scholar
Elbrecht A, Chen Y, Cullinan CA, Hayes N, Leibowitz Md, Moller DE, et al. Molecular cloning, expression and characterization of human peroxisome proliferator activated receptors γ1 and γ2. Biochem Biophys Res Commun. 1996; 224(2): 431-437.ElbrechtAChenYCullinanCAHayesNLeibowitzMdMollerDEMolecular cloning, expression and characterization of human peroxisome proliferator activated receptors γ1 and γ219962242431437Search in Google Scholar
Yen CJ, Beamer BA, Negri C, Silver K, Brown KA, Yarnall DP, et al. Molecular scanning of the human peroxisome proliferator activated receptor γ (hPPARγ) gene in diabetic Caucasians: Identification of a Pro12Ala PPARγ2 missense mutation. Biochem Biophys Res Commun. 1997; 241(2): 270-274.YenCJBeamerBANegriCSilverKBrownKAYarnallDPMolecular scanning of the human peroxisome proliferator activated receptor γ (hPPARγ) gene in diabetic Caucasians: Identification of a Pro12Ala PPARγ2 missense mutation19972412270274Search in Google Scholar
Deeb SS, Fajas L, Nemoto M, Pihlajamäki J, Mykkänen L, Kuusisto J, et al. A Pro12Ala substitution in PPARγ2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity. Nat Genet. 1998; 20(3): 284-287.DeebSSFajasLNemotoMPihlajamäkiJMykkänenLKuusistoJA Pro12Ala substitution in PPARγ2 associated with decreased receptor activity lower body mass index and improved insulin sensitivity1998203284287Search in Google Scholar
Yao YS, Li J, Jin YL, Chen Y, He LP. Association between PPAR-γ2 Pro12Ala polymorphism and obesity: A meta-analysis. Mol Biol Rep. 2015; 42(6): 1029-1038.YaoYSLiJJinYLChenYHeLP.Association between PPAR-γ2 Pro12Ala polymorphism and obesity: A meta-analysis201542610291038Search in Google Scholar
Tönjes A, Stumvoll M. The role of the Pro12Ala polymorphism in peroxisome proliferator-activated receptor γ in diabetes risk. Curr Opin Clin Nutr Metab Care. 2007; 10(4): 410-414.TönjesAStumvollM.The role of the Pro12Ala polymorphism in peroxisome proliferator-activated receptor γ in diabetes risk2007104410414Search in Google Scholar
Moon MK, Cho YM, Jung HS, Park YJ, Yoon KH, Sung YA, et al. Genetic polymorphisms in peroxisome proliferator-activated receptor γ are associated with type 2 diabetes mellitus and obesity in the Korean population. Diabet Med. 2005; 22(9): 1161-1166.MoonMKChoYMJungHSParkYJYoonKHSungYAGenetic polymorphisms in peroxisome proliferator-activated receptor γ are associated with type 2 diabetes mellitus and obesity in the Korean population200522911611166Search in Google Scholar
Ghoussaini M, Meyre D, Lobbens S, Charpentier G, Clément K, Charles MA, et al. Implication of the Pro12Ala polymorphism of the PPAR-γ2 gene in type 2 diabetes and obesity in the French population. BMC Med Genet. 2005; 6(11): 1-8.GhoussainiMMeyreDLobbensSCharpentierGClémentKCharlesMAImplication of the Pro12Ala polymorphism of the PPAR-γ2 gene in type 2 diabetes and obesity in the French population200561118Search in Google Scholar
Ben Ali S, Ben Yahia F, Sediri Y, Kallel A, Ftouhi B, Feki M, et al. Gender-specific effect of Pro12Ala polymorphism in peroxisome proliferator-activated receptor γ-2 gene on obesity risk and leptin levels in a Tunisian population. Clin Biochem. 2009; 42(16-17): 1642-1647.Ben AliSBen YahiaFSediriYKallelAFtouhiBFekiMGender-specific effect of Pro12Ala polymorphism in peroxisome proliferator-activated receptor γ-2 gene on obesity risk and leptin levels in a Tunisian population20094216-1716421647Search in Google Scholar
Takata N, Awata T, Inukai K, Watanabe M, Ohkubo T, Kurihara S, et al. Pro12Ala substitution in peroxisome proliferator-activated receptor γ2 is associated with low adiponectin concentrations in young Japanese men. Metabolism. 2004; 53(12): 1548-1551.TakataNAwataTInukaiKWatanabeMOhkuboTKuriharaSPro12Ala substitution in peroxisome proliferator-activated receptor γ2 is associated with low adiponectin concentrations in young Japanese men2004531215481551Search in Google Scholar
World Health Organization. Physical status: The use and interpretation anthropometry: Report of a WHO Expert Committee, WHO Technical Report Series, no. 854. Geneva, Switzerland: WHO. 1995; 321-344.World Health OrganizationGeneva, SwitzerlandWHO1995321344Search in Google Scholar
Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: Insulin resistance and β-cell function from fasting plasma glucose and insulin concentration in man. Diabetologia. 1985; 28(7): 412-419.MatthewsDRHoskerJPRudenskiASNaylorBATreacherDFTurnerRC.Homeostasis model assessment: Insulin resistance and β-cell function from fasting plasma glucose and insulin concentration in man1985287412419Search in Google Scholar
Miller SA, Dykes DD, Polesky HF. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res. 1988; 16(3): 1215.MillerSADykesDDPoleskyHF.A simple salting out procedure for extracting DNA from human nucleated cells9881631215Search in Google Scholar
Tellechea ML, Aranguren F, Perez MS, Cerrone GE, Frechtel GD, Taverna MJ. Pro12Ala polymorphism of the peroxisome proliferator activated receptor-γ gene is associated with metabolic syndrome and surrogate measures of insulin resistance in healthy men: Interaction with smoking status. Circ J. 2009; 73(11): 2118-2124.TellecheaMLArangurenFPerezMSCerroneGEFrechtelGDTavernaMJ.Pro12Ala polymorphism of the peroxisome proliferator activated receptor-γ gene is associated with metabolic syndrome and surrogate measures of insulin resistance in healthy men: Interaction with smoking status2009731121182124Search in Google Scholar
Beamer BA, Yen CJ, Andersen RE, Muller, Elahi D, Cheskin LJ, et al. Association of the Pro12Ala variant in the peroxisome proliferator-activated receptor-γ2 gene with obesity in two Caucasian populations. Diabetes. 1998; 47(11): 1806-1808.BeamerBAYenCJAndersenREMuller, ElahiDCheskinLJAssociation of the Pro12Ala variant in the peroxisome proliferator-activated receptor-γ2 gene with obesity in two Caucasian populations1998471118061808Search in Google Scholar
Masud S, Ye S; SAS Group. Effect of the peroxisome proliferator activated receptor-γ gene Pro12Ala variant on body mass index: A meta-analysis. J Med Genet. 2003; 40(10): 773-780.MasudSYeSSAS Group. Effect of the peroxisome proliferator activated receptor-γ gene Pro12Ala variant on body mass index: A meta-analysis20034010773780Search in Google Scholar
Gonzalez Sanchez JL, Serrano Rios M, Fernandez Perez C, Laakso M, Martinez Larrad MT. Effect of the Pro12Ala polymorphism of the peroxisome proliferator activated receptor γ-2 gene on adiposity, insulin sensitivity and lipid profile in the Spanish population. Eur J Endocrinol. 2002; 147(4): 495-501.Gonzalez SanchezJLSerrano RiosMFernandez PerezCLaaksoMMartinez LarradMT.Effect of the Pro12Ala polymorphism of the peroxisome proliferator activated receptor γ-2 gene on adiposity, insulin sensitivity and lipid profile in the Spanish population20021474495501Search in Google Scholar
Moffett SP, Feingold E, Barmada MM, Damcott CM, Marshall JA, Hamman RF, et al. The C161 → T polymorphism in peroxisome proliferator-activated receptor γ, but not P12A, is associated with insulin resistance in Hispanic and non-Hispanic white women: Evidence for another functional variant in peroxisome proliferator-activated receptor γ. Metabolism. 2005; 54(11): 1552-1556.MoffettSPFeingoldEBarmadaMMDamcottCMMarshallJAHammanRFThe C161 → T polymorphism in peroxisome proliferator-activated receptor γ, but not P12A, is associated with insulin resistance in Hispanic and non-Hispanic white women: Evidence for another functional variant in peroxisome proliferator-activated receptor γ2005541115521556Search in Google Scholar
Swarbrick MM, Chapman CM, McQuillan BM, Hung J, Thompson PL, Beilby JP. A Pro12Ala polymorphism in the human peroxisome proliferator-activated receptor-γ2 is associated with combined hyperlipidaemia in obesity. Eur J Endocrinol. 2001; 144(3): 277-282.SwarbrickMMChapmanCMMcQuillanBMHungJThompsonPLBeilbyJP.A Pro12Ala polymorphism in the human peroxisome proliferator-activated receptor-γ2 is associated with combined hyperlipidaemia in obesity20011443277282Search in Google Scholar
Paracchini V, Pedotti P, Taioli E. Genetics of leptin and obesity: a HuGE review. Am J Epidemiol. 2005; 162(2): 101-114.ParacchiniVPedottiPTaioliE.Genetics of leptin and obesity: a HuGE review20051622101114Search in Google Scholar
Schneider J, Kreuzer J, Hamann A, Nawroth PP, Dugi KA. The proline 12 alanine substitution in the peroxisome proliferator – Activated receptor-γ2 gene is associated with lower lipoprotein lipase activity in vivo. Diabetes. 2002; 51(13): 867-870.SchneiderJKreuzerJHamannANawrothPPDugiKA.The proline 12 alanine substitution in the peroxisome proliferator – Activated receptor-γ2 gene is associated with lower lipoprotein lipase activity in vivo20025113867870Search in Google Scholar
Hollenberg AN, Susulic VS, Madura JP, Zhang B, Moller DE, Tontonoz P, et al. Functional antagonism between CCAAT/enhancer binding protein-α and peroxisome proliferator-activated receptor-γ on the leptin promoter. J Biol Chem. 1997; 272(8): 5283-5290.HollenbergANSusulicVSMaduraJPZhangBMollerDETontonozPFunctional antagonism between CCAAT/enhancer binding protein-α and peroxisome proliferator-activated receptor-γ on the leptin promoter1997272852835290Search in Google Scholar
Akune T, Ohba S, Kamekura S, Yamaguchi M, Chung UI, Kubota N, et al. PPARγ insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors. J Clin Invest. 2004; 113(6): 846-855.AkuneTOhbaSKamekuraSYamaguchiMChungUIKubotaNPPARγ insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors20041136846855Search in Google Scholar
Simón I, Vendrell J, Gutiérrez C, Fernández-Real JM, Vendrell I, Gallart L, et al. Pro12Ala substitution in the peroxisome proliferator-activated receptor-γ is associated with increased leptin levels in women with type-2 diabetes mellitus. Horm Res. 2002; 58(3): 143-149.SimónIVendrellJGutiérrezCFernández-RealJMVendrellIGallartLPro12Ala substitution in the peroxisome proliferator-activated receptor-γ is associated with increased leptin levels in women with type-2 diabetes mellitus2002583143149Search in Google Scholar
Maeda N, Takahashi M, Funahashi T, Kihara S, Nishizawa H, Kishida K, et al. PPARγ ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein. Diabetes. 2001; 50(9): 2094-2099.MaedaNTakahashiMFunahashiTKiharaSNishizawaHKishidaKPPARγ ligands increase expression and plasma concentrations of adiponectin an adipose-derived protein200150920942099Search in Google Scholar
Moseti D, Regassa A, Kim WK. Molecular regulation of adipogenesis and potential anti-adipogenic bioactive molecules. Int J Mol Sci. 2016; 17(1): 1-24.MosetiDRegassaAKimWK.Molecular regulation of adipogenesis and potential anti-adipogenic bioactive molecules2016171124Search in Google Scholar
Duncan BB, Schmidt MI, Pankow JS, Bang H, Couper D, Ballantyne CM, et al. Adiponectin and the development of type 2 diabetes: The atherosclerosis risk in communities study. Diabetes. 2004; 53(9): 2373-2478.DuncanBBSchmidtMIPankowJSBangHCouperDBallantyneCMAdiponectin and the development of type 2 diabetes: The atherosclerosis risk in communities study200453923732478Search in Google Scholar
Mousavinasab F, Tähtinen T, Jokelainen J, Koskela P, Vanhala M, Oikarinen J, et al. Common poly-morphisms (single-nucleotide polymorphisms SNP+45 and SNP+276) of the adiponectin gene regulate serum adiponectin concentrations and blood pressure in young Finnish men. Mol Genet Metab. 2005; 87(2): 147-151.MousavinasabFTähtinenTJokelainenJKoskelaPVanhalaMOikarinenJCommon poly-morphisms (single-nucleotide polymorphisms SNP+45 and SNP+276) of the adiponectin gene regulate serum adiponectin concentrations and blood pressure in young Finnish men2005872147151Search in Google Scholar
Bhatt SP, Misra A, Sharma M, Luthra K, Guleria R, Pandey RM. Ala/Ala genotype of Pro12Ala polymorphism in the peroxisome proliferator-activated receptor-γ2 gene is associated with obesity and insulin resistance in Asian Indians. Diabetes Technol Ther. 2012; 14(9): 828-834.BhattSPMisraASharmaMLuthraKGuleriaRPandeyRM.Ala/Ala genotype of Pro12Ala polymorphism in the peroxisome proliferator-activated receptor-γ2 gene is associated with obesity and insulin resistance in Asian Indians2012149828834Search in Google Scholar
Takata N, Awata T, Inukai K, Watanabe M, Ohkubo T, Kurihara S, et al. Pro12Ala substitution in peroxisome proliferator-activated receptor γ2 is associated with low adiponectin concentrations in young Japanese men. Metabolism. 2004; 53(12): 1548-1551.TakataNAwataTInukaiKWatanabeMOhkuboTKuriharaSPro12Ala substitution in peroxisome proliferator-activated receptor γ2 is associated with low adiponectin concentrations in young Japanese men2004531215481551Search in Google Scholar
Yamamoto Y, Hirose H, Miyashita K, Nishikai K, Saito I, Taniyama M, et al. PPAR(γ)2 gene Pro12Ala polymorphism may influence serum level of an adipocyte-derived protein, adiponectin, in the Japanese population. Metabolism. 2002; 51(11): 1407-1409.YamamotoYHiroseHMiyashitaKNishikaiKSaitoITaniyamaMPPAR(γ)2 gene Pro12Ala polymorphism may influence serum level of an adipocyte-derived protein, adiponectin, in the Japanese population2002511114071409Search in Google Scholar
Vázquez-Del Mercado M, Guzmán-Ornelas MO, Corona Meraz FI, Ríos-Ibarra CP, Reyes-Serratos EA, Ruíz-Quezada SL, et al. The 482Ser of PPARGC1A and 12Pro of PPARG2 alleles are associated with reduction of metabolic risk factors even obesity in a Mexican-Mestizo population. Biomed Res Int. 2015: 1-14.Vázquez-Del MercadoMGuzmán-OrnelasMOCorona MerazFIRíos-IbarraCPReyes-SerratosEARuíz-QuezadaSLThe 482Ser of PPARGC1A and 12Pro of PPARG2 alleles are associated with reduction of metabolic risk factors even obesity in a Mexican-Mestizo population2015114Search in Google Scholar
Patel L, Buckels AC, Kinghorn IJ, Murdock PR, Holbrook JD, Plumpton C, et al. Resistin is expressed in human macrophages and directly regulated by PPARγ activators. Biochem Biophys Res Commun. 2003; 300(2): 472-476.PatelLBuckelsACKinghornIJMurdockPRHolbrookJDPlumptonCResistin is expressed in human macrophages and directly regulated by PPARγ activators20033002472476Search in Google Scholar
Muruganandan S, Roman AA, Sinal CJ. Adipocyte differentiation of bone marrow-derived mesenchymal stem cells: Cross talk with the osteoblastogenic program. Cell Mol Life Sci. 2009; 66(2): 236-253.MuruganandanSRomanAASinalCJ.Adipocyte differentiation of bone marrow-derived mesenchymal stem cells: Cross talk with the osteoblastogenic program2009662236253Search in Google Scholar
Muruganandan S, Parlee SD, Rourke JL, Ernst MC, Goralski KB, Sinal CJ. Chemerin, a novel peroxisome proliferator-activated receptorγ (PPARγ) target gene that promotes mesenchymal stem cell adipogenesis. J Biol Chem. 2011; 286(27): 23982-23995.MuruganandanSParleeSDRourkeJLErnstMCGoralskiKBSinalCJ.Chemerin, a novel peroxisome proliferator-activated receptorγ (PPARγ) target gene that promotes mesenchymal stem cell adipogenesis2011286272398223995Search in Google Scholar