Login
Registrieren
Passwort zurücksetzen
Veröffentlichen & Verteilen
Verlagslösungen
Vertriebslösungen
Themen
Allgemein
Altertumswissenschaften
Architektur und Design
Bibliotheks- und Informationswissenschaft, Buchwissenschaft
Biologie
Chemie
Geowissenschaften
Geschichte
Industrielle Chemie
Informatik
Jüdische Studien
Kulturwissenschaften
Kunst
Linguistik und Semiotik
Literaturwissenschaft
Materialwissenschaft
Mathematik
Medizin
Musik
Pharmazie
Philosophie
Physik
Rechtswissenschaften
Sozialwissenschaften
Sport und Freizeit
Technik
Theologie und Religion
Wirtschaftswissenschaften
Veröffentlichungen
Zeitschriften
Bücher
Konferenzberichte
Verlage
Blog
Kontakt
Suche
EUR
USD
GBP
Deutsch
English
Deutsch
Polski
Español
Français
Italiano
Warenkorb
Home
Zeitschriften
Balkan Journal of Medical Genetics
Band 19 (2016): Heft 1 (June 2016)
Uneingeschränkter Zugang
Assessment of genotoxicity of vincristine, vinblastine and vinorelbine in human cultured lymphocytes: a comparative study
NM Mhaidat
NM Mhaidat
,
KH Alzoubi
KH Alzoubi
,
OF Khabour
OF Khabour
,
KZ Alawneh
KZ Alawneh
,
LA Raffee
LA Raffee
,
ES Alsatari
ES Alsatari
,
EI Hussein
EI Hussein
und
KE Bani-Hani
KE Bani-Hani
| 02. Aug. 2016
Balkan Journal of Medical Genetics
Band 19 (2016): Heft 1 (June 2016)
Über diesen Artikel
Vorheriger Artikel
Nächster Artikel
Zusammenfassung
Artikel
Figuren und Tabellen
Referenzen
Autoren
Artikel in dieser Ausgabe
Vorschau
PDF
Zitieren
Teilen
Article Category:
Original Article
Online veröffentlicht:
02. Aug. 2016
Seitenbereich:
13 - 20
DOI:
https://doi.org/10.1515/bjmg-2016-0002
Schlüsselwörter
Chromosomal aberrations
,
Human blood lymphocyte
,
8-hydroxy-2-deoxy guanosine (8-OHdG)
,
Sister chromatid exchanges
,
Vincristine (VCR)
,
Vinblastine (VBL)
,
Vinorelbine (VRL)
© 2016 Walter de Gruyter GmbH, Berlin/Boston
This article is distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
The level of 8-OHdG values in controls, VCR, VBL and VRL groups; each at concentrations of 0.01 and 0.1 μg/mL. The levels of 8-OHdG in all drug-treated groups at concentrations of 0.01 and 0.1 μg/mL were higher than control group. The asterisks (*) indicate significant differences (p <0.05) from the control group. The hash (#) indicates significant difference from all other groups.
The average of SCEs/cell in controls, VCR, VBL and VRL groups; each at concentrations of 0.01 and 0.1 μg/mL in cultured blood cells. Increases were detected among the groups. However, it did not reach significant levels (control vs. VCR group: p >0.05; control vs. VBL group: p >0.05, and control vs. VRL group: p >0.05).
The mitotic index in cultured cells treated with VCR, VBL and VRL; each at concentrations of 0.01 and 0.1 μg/mL. The value of the mitotic index was significantly higher (p <0.05) in lymphocytes treated with VCR, VBL and VRL; each at concentrations of 0.01 and 0.1 μg/mL.