<abstract xmlns="http://www.w3.org/1999/xhtml"><p> A fraction from crude extract of Galega officinalis has been purified by column chromatography on Sephadex G-25, Sepharose 4B, DEAE-Cellulose and Sephadex G-100. The final purification factor of the fraction is 120. The peak in elution profile after Sephadex G-150 shows a molecular weight of 100-140 kDa. The isolated fraction appears to have 74% polysaccharides and 23% of proteins. No loss of activity of the final fraction is observed after storage for several months at 4°C and in lyophilized condition. The fraction compounds inhibit platelet aggregation induced by ADP, collagen and thrombin.</p></abstract>

A fraction from crude extract of Galega officinalis has been purified by column chromatography on Sephadex G-25, Sepharose 4B, DEAE-Cellulose and Sephadex G-100. The final purification factor of the fraction is 120. The peak in elution profile after Sephadex G-150 shows a molecular weight of 100-140 kDa. The isolated fraction appears to have 74% polysaccharides and 23% of proteins. No loss of activity of the final fraction is observed after storage for several months at 4°C and in lyophilized condition. The fraction compounds inhibit platelet aggregation induced by ADP, collagen and thrombin.

Anti-Platelet Fraction Isolated from Galega Officinalis

Department of Physics and Biophysics, Faculty of Medicine, Thracian University, Armeiska Str. 11 Bg − 6000 Stara Zagora,

Acta Medica Bulgarica

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

{"article-title":"Anti-Platelet Fraction Isolated from Galega Officinalis"}

A fraction from crude extract of Galega officinalis has been purified by column chromatography on Sephadex G-25, Sepharose 4B, DEAE-Cellulose and Sephadex...

Anti-Platelet Fraction Isolated from Galega Officinalis

Online veröffentlicht: 23. Nov. 2016

Seitenbereich: 5 - 10

DOI: https://doi.org/10.1515/amb-2016-0011

Schlüsselwörter
Galega officinalis, antiplatelet fraction

© 2016

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Anti-Platelet Fraction Isolated from Galega Officinalis

Online veröffentlicht: 23. Nov. 2016

Seitenbereich: 5 - 10

DOI: https://doi.org/10.1515/amb-2016-0011

SchlüsselwörterGalega officinalis, antiplatelet fraction

© 2016

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Schlüsselwörter
Galega officinalis, antiplatelet fraction