<abstract xmlns="http://www.w3.org/1999/xhtml"><sec id="j_1905-7415.1003.488_s_001_w2aab3b7b6b1b6b1aab1c16b1Aa"><h3>Background</h3><p>Catheter-related bladder discomfort (CRBD) is a distressing symptom after anesthesia.</p></sec><sec id="j_1905-7415.1003.488_s_002_w2aab3b7b6b1b6b1aab1c16b2Aa"><h3>Objective</h3><p><italic>To compare the efficacy of tramadol and ketamine to prevent CRBD after laparoscopic surgery</italic>.</p></sec><sec id="j_1905-7415.1003.488_s_003_w2aab3b7b6b1b6b1aab1c16b3Aa"><h3>Method</h3><p>After registration with the Thai Clinical Trial Registry (TCTR20140220001), we conducted a randomized controlled trial in 210 patients aged 18-70 years with American Society of Anesthesiologists physical status I or II undergoing elective laparoscopic surgery requiring bladder catheterization. These patients were randomly allocated into 1 of 3 groups: Group T received intravenous (i.v.) tramadol 1.5 mg/kg, Group K received i.v. ketamine 0.5 mg/kg, and Group P received i.v. saline as a placebo before catheterization. Patients received i.v. morphine for postoperative pain control. An anesthesiologist blinded to the randomization evaluated postoperative and CRBD pain severity using visual analog scales (VAS). The cumulative postoperative and CRBD pain was calculated by multiplying mean VAS scores by the hours of assessment.</p></sec><sec id="j_1905-7415.1003.488_s_004_w2aab3b7b6b1b6b1aab1c16b4Aa"><h3>Result</h3><p>Groups T and K had significantly less cumulative CRBD pain compared with placebo (<italic>P</italic> = 0.04 and 0.001, respectively). Cumulative postoperative pain, total 24-h morphine consumption, and adverse effects were comparable between groups. Group T had a significantly lower incidence of shoulder pain (7/67, 10%) than Group K (21/70, 30%), and Group P (24/70, 34%) 24 h after surgery (<italic>P</italic> = 0.006 and 0.001, respectively).</p></sec><sec id="j_1905-7415.1003.488_s_005_w2aab3b7b6b1b6b1aab1c16b5Aa"><h3>Conclusions</h3><p>Tramadol 1.5 mg/kg and ketamine 0.5 mg/kg administered i.v. before bladder catheterization are both effective in reducing the 24-h cumulative postoperative CRBD after laparoscopic surgery without significant adverse effects. Tramadol also decreases the incidence of postlaparoscopy shoulder pain.</p></sec></abstract>

BackgroundCatheter-related bladder discomfort (CRBD) is a distressing symptom after anesthesia.ObjectiveTo compare the efficacy of tramadol and ketamine to prevent CRBD after laparoscopic surgery.MethodAfter registration with the Thai Clinical Trial Registry (TCTR20140220001), we conducted a randomized controlled trial in 210 patients aged 18-70 years with American Society of Anesthesiologists physical status I or II undergoing elective laparoscopic surgery requiring bladder catheterization. These patients were randomly allocated into 1 of 3 groups: Group T received intravenous (i.v.) tramadol 1.5 mg/kg, Group K received i.v. ketamine 0.5 mg/kg, and Group P received i.v. saline as a placebo before catheterization. Patients received i.v. morphine for postoperative pain control. An anesthesiologist blinded to the randomization evaluated postoperative and CRBD pain severity using visual analog scales (VAS). The cumulative postoperative and CRBD pain was calculated by multiplying mean VAS scores by the hours of assessment.ResultGroups T and K had significantly less cumulative CRBD pain compared with placebo (P = 0.04 and 0.001, respectively). Cumulative postoperative pain, total 24-h morphine consumption, and adverse effects were comparable between groups. Group T had a significantly lower incidence of shoulder pain (7/67, 10%) than Group K (21/70, 30%), and Group P (24/70, 34%) 24 h after surgery (P = 0.006 and 0.001, respectively).ConclusionsTramadol 1.5 mg/kg and ketamine 0.5 mg/kg administered i.v. before bladder catheterization are both effective in reducing the 24-h cumulative postoperative CRBD after laparoscopic surgery without significant adverse effects. Tramadol also decreases the incidence of postlaparoscopy shoulder pain.

Comparison of intravenous tramadol and ketamine for prevention of catheter-related bladder discomfort after laparoscopic surgery: a randomized, placebo-controlled, double-blind study

Asian Biomedicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

BackgroundCatheter-related bladder discomfort (CRBD) is a distressing symptom after anesthesia.ObjectiveTo compare the efficacy of tramadol and ketamine to...

Comparison of intravenous tramadol and ketamine for prevention of catheter-related bladder discomfort after laparoscopic surgery: a randomized, placebo-controlled, double-blind study

Article Category: Brief communication (Original)

Published Online: Jan 31, 2017

Page range: 253 - 260

DOI: https://doi.org/10.5372/1905-7415.1003.488

Keywords
Catheter-related bladder discomfort, ketamine, laparoscopic surgery, laparoscopy, pain, prevention, tramadol

© 2016 Rattanaporn Burimsittichai, Phoonsak Limraksasin, Cameron Paul Hurst, Somrat Charuluxananan

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Comparison of intravenous tramadol and ketamine for prevention of catheter-related bladder discomfort after laparoscopic surgery: a randomized, placebo-controlled, double-blind study

Article Category: Brief communication (Original)

Published Online: Jan 31, 2017

Page range: 253 - 260

DOI: https://doi.org/10.5372/1905-7415.1003.488

KeywordsCatheter-related bladder discomfort, ketamine, laparoscopic surgery, laparoscopy, pain, prevention, tramadol

© 2016 Rattanaporn Burimsittichai, Phoonsak Limraksasin, Cameron Paul Hurst, Somrat Charuluxananan

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
Catheter-related bladder discomfort, ketamine, laparoscopic surgery, laparoscopy, pain, prevention, tramadol