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Soluble lectin-like oxidized low density lipoprotein receptor-1 in metabolic syndrome

Palakorn Puttaruk
Palakorn Puttaruk
, 
Duangnate Pipatsatitpong
Duangnate Pipatsatitpong
 and 
Pilaiwan Siripurkpong
Pilaiwan Siripurkpong
   | Jan 31, 2017
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Article Category: Brief communication (Original)
Published Online: Jan 31, 2017
Page range: 675 - 682
DOI: https://doi.org/10.5372/1905-7415.0905.439
Keywords
© 2015 Palakorn Puttaruk, Duangnate Pipatsatitpong, Pilaiwan Siripurkpong
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Figure 1

Serum levels of sLOX-1 in metabolic syndrome. A (left) Comparison of the sLOX-1 levels in metabolic syndrome and control with non-metabolic syndrome, and B (right) Comparison of the sLOX-1 levels in male (open bars) and female (solid bars) separately in both groups.
Serum levels of sLOX-1 in metabolic syndrome. A (left) Comparison of the sLOX-1 levels in metabolic syndrome and control with non-metabolic syndrome, and B (right) Comparison of the sLOX-1 levels in male (open bars) and female (solid bars) separately in both groups.

Multiple linear regression analysis of soluble lectin-like oxidized low density lipoprotein receptor-1 and age, blood pressure (BP), body mass index (BMI), fasting plasma glucose (FPG), total cholesterol, triglyceride, and high-density lipoprotein (HDL) cholesterol

Independent factors

Unstandardized coefficients

Standardized coefficients

t

(P < 0.05)

β

Std. Error

β

Constant

–140.1

19.9

–7.05

<0.001

Age

0.41

0.19

0.09

2.21

0.03

Systolic BP

1.06

0.20

0.35

5.26

<0.001

Diastolic BP

–0.17

0.29

–0.03

–0.58

0.56

Body mass index

4.07

0.63

0.30

6.43

<0.001

Fasting plasma glucose

0.21

0.08

0.11

2.58

0.01

Total cholesterol

–0.07

0.05

–0.06

–1.44

0.15

Triglyceride

0.08

0.02

0.198

4.39

<0.001

HDL cholesterol

–0.14

0.09

–0.06

–1.48

0.14

Characteristics of all enrolled participants

Characteristics

Metabolic syndrome (n = 148)

Control with non-metabolic syndrome (n = 206)

P

Sex

 Female, n (%)

87 (59)

131 (64)

 Male, n (%)

61 (41)

75 (36)

0.36

Chi-square test

Age (years)

51.6 (11.7)

44 (11.9)

<0.001

*P < 0.05.

Student t test

Body mass index (kg/m2)

27.9 (25.8-30.1)

21.7 (19.923.5)

<0.001

*P < 0.05.

Mann–Whitney U test

Blood pressure (BP) (mmHg)

 Systolic BP

139 (132.0-150.0)

110 (105.0-115.0)

<0.001

*P < 0.05.

Mann–Whitney U test

 Diastolic BP

84 (77.3-91.0)

70 (64.8-73.0)

<0.001

*P < 0.05.

Mann–Whitney U test

Fasting plasma glucose (mg/dL)

101 (89.0-125.8)

85.5 (81.8-90.0)

<0.001

*P < 0.05.

Mann–Whitney U test

Total cholesterol (mg/dL)

226.4 (49.2)

205.9 (40.5)

<0.001

*P < 0.05.

Student t test

HDL cholesterol (mg/dL)

45 (37.0-53.8)

62 (53.074.0)

<0.001

*P < 0.05.

Mann–Whitney U test

LDL cholesterol (mg/dL)

118.5 (45.8)

118.8 (35.8)

0.94

Student t test

Triglyceride (mg/dL)

192 (155.0-238.8)

69 (52.895.3)

<0.001

*P < 0.05.

Mann–Whitney U test

Univariate and multivariate analyses of risk factors for metabolic disorder

Variables

Case

Control

Crude OR

P

Adjusted OR

P

n (%)

n (%)

(95%CI)

(95%CI)

Sex

 Male

61 (41)

75 (36)

1

 Female

87 (59)

131 (64)

0.8 (0.5-1.3)

0.36

Age (years)

 25-35

17 (12)

60 (29)

1

0.24

1

 36-45

26 (18)

60 (29)

1.5 (0.8-3.1)

<0.001

P < 0.05

0.1 (0.004-2.9)

0.181

 46-55

48 (32)

50 (24)

3.4 (1.7-6.6)

<0.001

P < 0.05

0.9 (0.1-9.4)

0.942

 >55

57 (38)

36 (18)

5.6 (2.8-11.0)

<0.001

P < 0.05

2.1 (0.2-2 0 . 5)

0.518

Body mass index (kg/m2)

1

 Normal

30 (20)

195 (95)

1

82.3

<0.001

P < 0.05

 Over weight

118 (80)

11(5)

69.7 (33.7-144.4)

<0.001

P < 0.05

(10.7-631.9)

Systolic BP (mmHg)

148 (100)

206 (100)

1.2 (1.2-1.3)

<0.001

P < 0.05

Diastolic BP (mmHg)

148 (100)

206 (100)

1.2 (1.1-1.2)

<0.001

P < 0.05

FPG (mg/dL)

148 (100)

206 (100)

1.1 (1.1-1.2)

<0.001

P < 0.05

1.1 (1.1-1.2)

<0.001

P < 0.05

Total cholesterol (mg/dL) 148 (100)

206 (100)

1.01 (1.00-1.02)

<0.001

P < 0.05

Triglyceride (mg/dL)

148 (100)

206 (100)

1.1 (1.0-1.1)

<0.001

P < 0.05

1.1 (1.0-1.1)

<0.001

P < 0.05

HDL cholesterol (mg/dL) 148 (100)

206 (100)

0.96 (0.95-0.98)

<0.001

P < 0.05

0.96 (0.93-0.99)

0.002

P < 0.05

LDL cholesterol (mg/dL)

148 (100)

206 (100)

1.00 (0.99-1 . 0 1 )

0.937

sLOX-1 (pg/mL)

148 (100)

206 (100)

1.2 (1.1-1.4)

<0.001

P < 0.05

Correlation of soluble lectin-like oxidized low density lipoprotein receptor-1 with age, sex, body mass index, blood pressure, fasting plasma glucose and lipid profiles.

Characteristic

Correlation coefficient (r)

p

Age

0.29

<0.001*

Sex

–0.002

0.997

Body mass index

0.62

<0.001*

Blood Pressure (BP)

Systolic BP

0.63

<0.001*

Diastolic BP

0.48

<0.001*

Fasting plasma glucose

0.495

<0.001*

Total cholesterol

0.177

0.001*

Triglyceride

0.633

<0.001*

High-density lipoprotein cholesterol

–0.384

<0.001*

Low-density lipoprotein cholesterol

–0.041

0.46

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