<abstract xmlns="http://www.w3.org/1999/xhtml"><sec id="j_1905-7415.0904.421_s_001_w2aab3b7b8b1b6b1aab1c17b1Aa"><h3>Background</h3><p>Cross-sex hormone (CSH) use is widespread among transsexuals in Thailand. CSHs are used by male-to-female (MtF) transsexuals for feminization.</p></sec><sec id="j_1905-7415.0904.421_s_002_w2aab3b7b8b1b6b1aab1c17b2Aa"><h3>Objectives</h3><p>To determine effects of self-medication with CSH on cardiovascular risk biomarkers, C-reactive protein (CRP) and fibrinogen (Fb), in Thai MtF transsexuals.</p></sec><sec id="j_1905-7415.0904.421_s_003_w2aab3b7b8b1b6b1aab1c17b3Aa"><h3>Methods</h3><p>Data were collected from healthy MtF transsexual cabaret dancers in Pattaya city, Thailand, using a questionnaire and descriptive interview. Blood samples were collected to determine lipid profile, CRP, Fb, and sex hormone levels. ANOVA, Pearson correlation, and logistic regression were analyzed for effects of CSH on biomarkers; comparing CSH users with non-using controls.</p></sec><sec id="j_1905-7415.0904.421_s_004_w2aab3b7b8b1b6b1aab1c17b4Aa"><h3>Results</h3><p>We grouped 102 MtF transsexual participants (average age 28 years) as CSH (n = 66) and non-hormone using controls (n = 36). Several female and antimale hormonal products were used in CSH self-medication, with an average 12.5-year exposure. In the CSH group, significantly higher HDL with lower CRP levels and a negative correlation between total cholesterol, LDL, and 17β-estradiol were observed. Risk prevalence analysis exhibited lower prevalence of disease susceptibility in the CSH group. Logistic regression accordingly revealed the effect of CSH on CRP levels with odds ratios of 0.26 (CI 0.1-0.68) and 0.34 (CI 0.13-0.93) in crude and adjusted models, respectively.</p></sec><sec id="j_1905-7415.0904.421_s_005_w2aab3b7b8b1b6b1aab1c17b5Aa"><h3>Conclusions</h3><p>Moderate exposure to low doses of CSH use showed no serious risk or health problems in healthy MtF transsexuals in terms of cardiovascular risk biomarkers</p></sec></abstract>

BackgroundCross-sex hormone (CSH) use is widespread among transsexuals in Thailand. CSHs are used by male-to-female (MtF) transsexuals for feminization.ObjectivesTo determine effects of self-medication with CSH on cardiovascular risk biomarkers, C-reactive protein (CRP) and fibrinogen (Fb), in Thai MtF transsexuals.MethodsData were collected from healthy MtF transsexual cabaret dancers in Pattaya city, Thailand, using a questionnaire and descriptive interview. Blood samples were collected to determine lipid profile, CRP, Fb, and sex hormone levels. ANOVA, Pearson correlation, and logistic regression were analyzed for effects of CSH on biomarkers; comparing CSH users with non-using controls.ResultsWe grouped 102 MtF transsexual participants (average age 28 years) as CSH (n = 66) and non-hormone using controls (n = 36). Several female and antimale hormonal products were used in CSH self-medication, with an average 12.5-year exposure. In the CSH group, significantly higher HDL with lower CRP levels and a negative correlation between total cholesterol, LDL, and 17β-estradiol were observed. Risk prevalence analysis exhibited lower prevalence of disease susceptibility in the CSH group. Logistic regression accordingly revealed the effect of CSH on CRP levels with odds ratios of 0.26 (CI 0.1-0.68) and 0.34 (CI 0.13-0.93) in crude and adjusted models, respectively.ConclusionsModerate exposure to low doses of CSH use showed no serious risk or health problems in healthy MtF transsexuals in terms of cardiovascular risk biomarkers

Cross-sex hormone use does not increase cardiovascular risk in young male-to-female transsexuals: a study of self-medication by healthy Thai cabaret dancers

Asian Biomedicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

BackgroundCross-sex hormone (CSH) use is widespread among transsexuals in Thailand. CSHs are used by male-to-female (MtF) transsexuals for...

Cross-sex hormone use does not increase cardiovascular risk in young male-to-female transsexuals: a study of self-medication by healthy Thai cabaret dancers

Article Category: Brief communication (Original)

Published Online: Jan 31, 2017

Page range: 511 - 518

DOI: https://doi.org/10.5372/1905-7415.0904.421

Keywords
C-reactive protein, cardiovascular, estrogen, fibrinogen, male-to-female transsexuals progesterone, testosterone

© 2015 Prawit Onpanna, Paiboon Daosodsai, Kawin Leelawat, Supatra Porasuphatana

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Cross-sex hormone use does not increase cardiovascular risk in young male-to-female transsexuals: a study of self-medication by healthy Thai cabaret dancers

Article Category: Brief communication (Original)

Published Online: Jan 31, 2017

Page range: 511 - 518

DOI: https://doi.org/10.5372/1905-7415.0904.421

KeywordsC-reactive protein, cardiovascular, estrogen, fibrinogen, male-to-female transsexuals progesterone, testosterone

© 2015 Prawit Onpanna, Paiboon Daosodsai, Kawin Leelawat, Supatra Porasuphatana

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
C-reactive protein, cardiovascular, estrogen, fibrinogen, male-to-female transsexuals progesterone, testosterone