| Total symptom score (mean (95% CI)) |
| Baseline | 9.50 (7.19,11.81) | 10.80 (9.37,12.23) | 10.18 (7.99,12.37) | 0.62 | 1.00 | 1.00 | 1.00 |
| Post-treatment | 5.05 (3.42,6.67) | 5.28 (4.21,6.35) | 5.86 (4.83,6.90) | 0.63 | 1.00 | 1.00 | 1.00 |
| Change | 4.45 (2.51,6.40) | 5.52 (3.98,7.06) | 4.32 (2.43,6.21) | 0.55 | 1.00 | 1.00 | 0.96 |
| Nonotolaryngic symptoms (mean (95% CI)) |
| Baseline | 13.77 (9.74,17.81) | 12.88 (10.20,15.56) | 12.27 (9.65,14.89) | 0.79 | 1.00 | 1.00 | 1.00 |
| Post-treatment | 7.59 (4.09,11.09) | 5.68 (3.82,7.54) | 6.95 (4.17,9.74) | 0.57 | 1.00 | 0.91 | 1.00 |
| Change | 6.18 (3.44,8.92) | 7.20 (4.41,9.99) | 5.32 (2.82,7.82) | 0.59 | 1.00 | 1.00 | 0.92 |
| Work and study performance (mean (95% CI)) |
| Baseline | 1.86 (1.01,2.72) | 2.60 (1.53,3.67) | 1.91 (1.20,2.62) | 0.40 | 0.71 | 1.00 | 0.80 |
| Post-treatment | 0.91 (0.24,1.58) | 1.00 (0.29,1.71) | 0.91 (0.42,1.40) | 0.97 | 1.00 | 1.00 | 1.00 |
| Change | 0.95 (0.34,1.57) | 1.60 (0.55,2.65) | 1.00 (0.42,1.58) | 0.42 | 0.73 | 1.00 | 0.84 |
| Exertion (mean (95% CI)) |
| Baseline | 2.55 (1.51,3.59) | 2.04 (0.92,3.16) | 2.36 (1.37,3.36) | 0.77 | 1.00 | 1.00 | 1.00 |
| Post-treatment | 1.23 (0.44,2.01) | 0.88 (0.18,1.58) | 1.45 (0.57,2.34) | 0.55 | 1.00 | 1.00 | 0.85 |
| Change | 1.32 (0.50,2.13) | 1.16 (0.42,1.90) | 0.91 (0.24,2.06) | 0.81 | 1.00 | 1.00 | 1.00 |
| Sleep disturbance (mean (95% CI)) |
| Baseline | 3.59 (2.23,4.95) | 4.04 (2.86,5.22) | 4.36 (2.99,5.74) | 0.69 | 1.00 | 1.00 | 1.00 |
| Post-treatment | 1.55 (0.84,2.25) | 1.76 (0.73,2.79) | 1.73 (0.85,2.61) | 0.93 | 1.00 | 1.00 | 1.00 |
| Change | 2.05 (1.04,3.06) | 2.28 (1.12,3.44) | 2.64 (1.42,3.85) | 0.76 | 1.00 | 1.00 | 1.00 |
| Social disturbance (mean (95% CI)) |
| Baseline | 1.82 (0.73,2.91) | 2.80 (1.62,3.98) | 2.68 (1.45,3.92) | 0.42 | 0.66 | 0.89 | 1.00 |
| Post-treatment | 1.14 (0.37,1.90) | 1.52 (0.57,2.47) | 0.86 (0.28,1.45) | 0.48 | 1.00 | 1.00 | 0.69 |
| Change | 1.82 (0.83,2.80) | 1.28 (0.39,2.17) | 1.82 (0.83,2.80) | 0.16 | 0.88 | 1.17 | 1.00 |
| Emotional disturbance (mean(95%CI)) |
| Baseline | 6.41 (4.15,8.67) | 7.88 (5.63,10.13) | 8.14 (5.58,10.70) | 0.52 | 1.00 | 0.89 | 1.00 |
| Post-treatment | 2.77 (1.56,3.98) | 3.60 (2.05,5.15) | 3.23 (1.85,4.60) | 0.69 | 1.00 | 1.00 | 1.00 |
| Change | 3.64 (1.92,5.35) | 4.28 (2.17,6.39) | 4.91 (2.80,7.02) | 0.66 | 1.00 | 1.00 | 1.00 |
| Overall general health (mean (95% CI)) |
| Baseline | 2.14 (1.77,2.51) | 2.08 (1.74,2.42) | 1.77 (1.41,2.13) | 0.29 | 1.00 | 0.44 | 0.61 |
| Post-treatment | 2.50 (2.17,2.83) | 2.68 (2.42,2.94) | 2.14 (1.89,2.38) | 0.02 | 1.00 | 0.20 | 0.02 |
| Change | 0.36 (–0.01,0.74) | 0.60 (0.22,0.98) | 0.36 (0.01,0.71) | 0.55 | 1.00 | 1.00 | 1.00 |
| PNIF (L/min) (mean (95% CI)) |
| Baseline | 93.86 (79.06,108.66) | 92.71 (80.70,104.72) | 92.27 (78.85,105.69) | 0.98 | 1.00 | 1.00 | 1.00 |
| Post-treatment | 93.86 (75.23,112.50) | 92.20 (81.51,102.89) | 90.91 (78.68,103.14) | 0.96 | 1.00 | 1.00 | 1.00 |
| Change | 0 (–9.25,9.25) (17.74,28.35) | 3.20 (–11.84,18.24) (20.60,28.04) | –1.36 (–11.23,8.51) (18.05,28.68) | 0.85 | 1.00 | 1.00 | 1.00 |
| Change | –12.27 (–19.05,-5.49) | –13.52 (–18.61, –8.43) | –14.09 (–19.95, –8.23) | 0.90 | 1.00 | 1.00 | 1.00 |
| Wheal size (mm) (mean (95% CI)) |
| Baseline | 11.36 (9.44,13.29) | 14.04 (11.64,16.44) | 14.00 (9.56,18.44) | 0.29 | 0.68 | 0.42 | 1.00 |
| Post-treatment | 8.91 (7.04,10.78) | 10.24 (8.52,11.96) | 9.77 (7.36,12.18) | 0.61 | 1.00 | 0.99 | 1.00 |
| Change | –2.45 (–4.56, –0.55) | –1.24 (–6.50, –1.98) | –4.23 (–6.95, –1.51) | 0.44 | 0.83 | 0.77 | 1.00 |
| Flare size (mm) (mean (95% CI)) |
| Baseline | 35.32 (29.94,40.69) | 38.58 (33.11,44.05) | 37.45 (28.79,46.12) | 0.84 | 1.00 | 1.00 | 1.00 |
| Post-treatment | 23.05 (17.74,28.35) | 24.32 (20.60,28.04) | 23.36 (18.05,28.68) | 0.92 | 1.00 | 1.00 | 1.00 |
| Change | –12.27 (–19.05,-5.49) | –13.52 (–18.61, –8.43) | –14.09 (–19.95, –8.23) | 0.90 | 1.00 | 1.00 | 1.00 |
