<abstract xmlns="http://www.w3.org/1999/xhtml"><sec id="j_1905-7415.0903.395_s_001_w2aab3b7b1b1b6b1aab1c16b1Aa"><h3>Background</h3><p>Basic fibroblast growth factor (bFGF) plays a crucial role in various biological processes, including cell growth, survival, migration, and differentiation. In stem cell biology, bFGF is employed to maintain stemness and regulate differentiation.</p></sec><sec id="j_1905-7415.0903.395_s_002_w2aab3b7b1b1b6b1aab1c16b2Aa"><h3>Objectives</h3><p>To review the role of bFGF in the behavior of stem cells, focusing particularly on human dental tissue-derived mesenchymal stem cells (DMSCs).</p></sec><sec id="j_1905-7415.0903.395_s_003_w2aab3b7b1b1b6b1aab1c16b3Aa"><h3>Methods</h3><p>The articles from January 1, 1990 to March 25, 2015 in the PubMed database were searched with assigned key words (dental stem cells and (bFGF or FGF2)). Titles and abstracts of the retrieved articles were evaluated to identify inclusion criteria.</p></sec><sec id="j_1905-7415.0903.395_s_004_w2aab3b7b1b1b6b1aab1c16b4Aa"><h3>Results</h3><p>Sixty-five articles were identified from the PubMed database using the assigned keywords. Eighteen articles met the inclusion criteria including: (1) articles published in English, (2) articles describing the effects of endogenous and exogenous bFGF in cell culture and animal studies, and (3) the cell model used in the study was derived from dental-related tissues, and were employed as the main articles discussed in the present narrative review.</p></sec><sec id="j_1905-7415.0903.395_s_005_w2aab3b7b1b1b6b1aab1c16b5Aa"><h3>Conclusion</h3><p>bFGF supplementation enhances stem cell marker expression in DMSCs. However, the role of bFGF on osteogenic differentiation by DMSCs remains controversial.</p></sec></abstract>

BackgroundBasic fibroblast growth factor (bFGF) plays a crucial role in various biological processes, including cell growth, survival, migration, and differentiation. In stem cell biology, bFGF is employed to maintain stemness and regulate differentiation.ObjectivesTo review the role of bFGF in the behavior of stem cells, focusing particularly on human dental tissue-derived mesenchymal stem cells (DMSCs).MethodsThe articles from January 1, 1990 to March 25, 2015 in the PubMed database were searched with assigned key words (dental stem cells and (bFGF or FGF2)). Titles and abstracts of the retrieved articles were evaluated to identify inclusion criteria.ResultsSixty-five articles were identified from the PubMed database using the assigned keywords. Eighteen articles met the inclusion criteria including: (1) articles published in English, (2) articles describing the effects of endogenous and exogenous bFGF in cell culture and animal studies, and (3) the cell model used in the study was derived from dental-related tissues, and were employed as the main articles discussed in the present narrative review.ConclusionbFGF supplementation enhances stem cell marker expression in DMSCs. However, the role of bFGF on osteogenic differentiation by DMSCs remains controversial.

Review of the role of basic fibroblast growth factor in dental tissue-derived mesenchymal stem cells

Department of Pharmacology, Faculty of Veterinary Science

Department of Anatomy, Faculty of Dentistry

Asian Biomedicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

BackgroundBasic fibroblast growth factor (bFGF) plays a crucial role in various biological processes, including cell growth, survival, migration, and...

Review of the role of basic fibroblast growth factor in dental tissue-derived mesenchymal stem cells

Article Category: Review article

Published Online: Jan 31, 2017

Page range: 271 - 283

DOI: https://doi.org/10.5372/1905-7415.0903.395

Keywords
Basic fibroblast growth factor, dental tissue-derived stem cells, differentiation, stemness

© 2015 Nunthawan Nowwarote, Chenphop Sawangmake, Prasit Pavasant, Thanaphum Osathanon

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Review of the role of basic fibroblast growth factor in dental tissue-derived mesenchymal stem cells

Article Category: Review article

Published Online: Jan 31, 2017

Page range: 271 - 283

DOI: https://doi.org/10.5372/1905-7415.0903.395

KeywordsBasic fibroblast growth factor, dental tissue-derived stem cells, differentiation, stemness

© 2015 Nunthawan Nowwarote, Chenphop Sawangmake, Prasit Pavasant, Thanaphum Osathanon

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
Basic fibroblast growth factor, dental tissue-derived stem cells, differentiation, stemness