Comparison of exercise treadmill test, flow mediated dilatation, and inflammation in individuals with low risk of adverse cardiovascular events
, , , , , , , and | Jan 31, 2017
About this article
Article Category: Brief communication (Original)
Published Online: Jan 31, 2017
Page range: 147 - 154
DOI: https://doi.org/10.5372/1905-7415.0902.380
Keywords
© 2017 Muhammed Sait Toprak, Zeynep Gungor Ozturk, Ozlem Balci Ekmekci, Hakan Ekmekci, Baris Ikitimur, Bilgehan Karadag, Huseyin Altug Cakmak, Baris Ilerigelen, Huseyin Sonmez
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.
Figure 1
Figure 2
Endothelial biomarkers and flow mediated dilatation (FMD) between exercise treadmill test (ETT) results
| Endothelial biomarkers | ETT (–) N = 30 | ETT (+) N = 30 | |
|---|---|---|---|
| Lp-PLA2 (IU/ml) | 296.64 (223.59-365.43) | 173,86 (124.92-305.07) | 0.009 |
| Oxidized LDL (ng/ml) | 66.22 (62.55-93.48) | 63.88 (57.90-102.31) | NS |
| hs-CRP (mg/L) | 1.54 (0.86-3.06) | 1.11 (0.56-2.26) | 0.07 |
| Nitric oxide (µM) | 55.67 + 13.43 | 46.76 + 13.53 | 0.06 |
| Sialic acid (mg/ml) | 43.15 + 10.92 | 45.04 + 10.35 | NS |
| FMD1 (%) | 48.48 (32.21-65.78) | 35.27 (16. 99-62.54) | NS |
| FMD2 (%) | 56.37 + 39.54 | 51.41 + 33.18 | NS |
Clinical characteristics of patients between exercise treadmill test (ETT) results
| Clinical Characteristics | ETT (–) N = 30 | ETT (+) N = 30 | |
|---|---|---|---|
| Age (years) | 48 ± 7 | 56 ± 7 | <0.05 |
| Men/women (number) | 17/13 | 20/10 | 0.057 |
| BMI (kg/m2) | 27.8 ± 3.6 | 26.2 ± 2.8 | NS |
| Systolic blood pressure (mmHg) | 130 ±20 | 140 ± 10 | 0.08 |
| Diastolic blood pressure (mmHg) | 80 ± 10 | 80 ± 10 | NS |
| Diabetic (%) | 10 | 16.7 | NS |
| Triglyceride (mg/dL) | 154 ± 77 | 141 ± 64 | NS |
| Total cholesterol (mg/dL) | 215 ± 46 | 191 ± 28 | 0.017 |
| LDL cholesterol (mg/dL) | 140 ± 37 | 136 ± 30 | NS |
| HDL cholesterol (mg/dL) | 53 ± 17 | 46 ± 8 | 0.07 |
| Glucose (mg/dL) | 102 ± 32 | 102 ± 14 | NS |
| Blocked vessel (%) | 0% | 23, 3% | 0.005 |
Patient characteristics and endothelial biomarkers across FMD tertiles
| 1st tertile (<16%) | 2nd tertile (16%-54%) | 3rd tertile(>54%) | ||
|---|---|---|---|---|
| Age | 51 ± 8 | 52 ± 9 | 53 ± 8 | NS |
| BMI | 28.4 ± 3.9 | 26.3 ± 2.8 | 26.5 ± 3.3 | NS |
| Smoking (%) | 20% (2) | 40% (4) | 40% (4) | NS |
| Family history (%) | 44% (4) | 33% (3) | 22% (2) | NS |
| Systolic BP (mmHg) | 134 ± 17 | 130 ± 14 | 131 ± 12 | NS |
| Diastolic BP (mmHg) | 80 ± 6 | 80 ± 5 | 80 ± 8 | NS |
| Triglyceride (mg/dl) | 149 (101-237) | 123 (82-165) | 127 (89-199) | NS |
| Total cholesterol (mg/dl) | 214 ± 45 | 191 ± 32 | 203 ± 39 | NS |
| LDL cholesterol (mg/dl) | 144 ± 36 | 130 ± 28 | 141 ± 36 | NS |
| HDL cholesterol (mg/dl) | 51 ± 18 | 47 ± 10 | 50 ± 12 | NS |
| Glucose (mg/dl) | 96 (87-104) | 103 (91-109) | 94 (87-117) | NS |
| Lp-PLA2 (IU/ml) | 274.9 (193.9-365.8) | 269.6 (147.3-369.6) | 254.8 (141.1-310.7) | NS |
| Oxidized LDL (ng/ml) | 66.9 (63.2-82.4) | 63.9 (60.5-69.1) | 64.9 (59.9-168.7) | NS |
| hs-CRP (mg/L) | 1.4 (0.8-4.7) | 1.3 (0.7-2.2) | 1.5 (0.4-2.4) | NS |
| Nitric oxide (µM) | 53 ± 12 | 47 ± 14 | 54 ± 15 | NS |
| Sialic acid (mg/ml) | 43.5 ± 10.7 | 43.2 ± 10.9 | 45.6 ± 10.5 | NS |