<abstract xmlns="http://www.w3.org/1999/xhtml"> Background: Acquired factor VII (FVII) deficiency mostly results from liver disease or vitamin K antagonists. Isolated acquired FVII deficiency is a rare event, and only a few cases have been reported. To our knowledge, this is the first reported case of synovial sarcoma associated with FVII deficiency.Objective: To describe our findings in a 20-year-old man, who presented with hemoptysis, weight loss, and later developed a suprascapular mass.Methods: A review of the medical record of the patient plus a comparison with the literature was conducted.Results: A biopsy from a suprascapular mass was made and the histopathological diagnosis of the tumor was confirmed as synovial sarcoma. Initial studies indicated a normal activated partial thromboplastin time and a prolonged prothrombin time. The FVII level was 31%. No evidence of a FVII inhibitor or inactivator was demonstrated. Prothrombin time normalized during tumor regression and FVII level was elevated to 103%.Conclusion: Clinicians should be alert to the possible association of acquired FVII deficiency in cancer patients.</abstract>

Background: Acquired factor VII (FVII) deficiency mostly results from liver disease or vitamin K antagonists. Isolated acquired FVII deficiency is a rare event, and only a few cases have been reported. To our knowledge, this is the first reported case of synovial sarcoma associated with FVII deficiency.Objective: To describe our findings in a 20-year-old man, who presented with hemoptysis, weight loss, and later developed a suprascapular mass.Methods: A review of the medical record of the patient plus a comparison with the literature was conducted.Results: A biopsy from a suprascapular mass was made and the histopathological diagnosis of the tumor was confirmed as synovial sarcoma. Initial studies indicated a normal activated partial thromboplastin time and a prolonged prothrombin time. The FVII level was 31%. No evidence of a FVII inhibitor or inactivator was demonstrated. Prothrombin time normalized during tumor regression and FVII level was elevated to 103%.Conclusion: Clinicians should be alert to the possible association of acquired FVII deficiency in cancer patients.

Acquired factor VII deficiency associated with synovial sarcoma

Division of Oncology, Internal Medicine Department, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002,

Hematology Division, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002,

Pathological Department, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002,

Asian Biomedicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

{"article-title":"Acquired factor VII deficiency associated with synovial sarcoma"}

Background: Acquired factor VII (FVII) deficiency mostly results from liver disease or vitamin K antagonists. Isolated acquired FVII deficiency is a rare...

Acquired factor VII deficiency associated with synovial sarcoma

Article Category: Clinical report

Published Online: Feb 04, 2017

Page range: 123 - 126

DOI: https://doi.org/10.5372/1905-7415.0801.271

Keywords
Bleeding, factor VII deficiency, soft tissue sarcoma

© 2017

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Acquired factor VII deficiency associated with synovial sarcoma

Article Category: Clinical report

Published Online: Feb 04, 2017

Page range: 123 - 126

DOI: https://doi.org/10.5372/1905-7415.0801.271

KeywordsBleeding, factor VII deficiency, soft tissue sarcoma

© 2017

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Keywords
Bleeding, factor VII deficiency, soft tissue sarcoma