<abstract xmlns="http://www.w3.org/1999/xhtml"> Background: Only a few cases of Leiomyomatoid angiomatous neuroendocrine tumor (LANT) have been reported in the literature. Our case adds clinical, pathological, and immunohistochemical features.Objective: To investigate the clinicopathological characteristics of LANT.Material and Method: One case of LANT of the myometrium was reported in a review of literature. The morphological and immunohistochemical features were analyzed.Results: In the course of an annual health examination of a 40-year-old woman, ultrasound results revealed a mass in the myometrium, which was clinically diagnosed as uterine leiomyoma. The patient underwent hysterectomy. Histological examination demonstrated that the tumor was composed of prominent vasculature and cellular stromal around vessels. Mitotic activity was absent. Both vascular and stromal cells showed diffusely expressed CD56 and chromogranin A. Stromal cells also expressed actin, SMA, and desmin, but not CK or HMB45. The pathological diagnosis was LANT of the myometrium. Follow up reported no evidence of recurrence three months after surgery.Conclusion: LANT is a possible new disease entity. LANT is a dimorphic tumor consisting of smooth muscle and neurosecretory phenotype cells surrounding intratumoral vessels. Surgery may be the best treatment, resulting in good prognosis.</abstract>

Background: Only a few cases of Leiomyomatoid angiomatous neuroendocrine tumor (LANT) have been reported in the literature. Our case adds clinical, pathological, and immunohistochemical features.Objective: To investigate the clinicopathological characteristics of LANT.Material and Method: One case of LANT of the myometrium was reported in a review of literature. The morphological and immunohistochemical features were analyzed.Results: In the course of an annual health examination of a 40-year-old woman, ultrasound results revealed a mass in the myometrium, which was clinically diagnosed as uterine leiomyoma. The patient underwent hysterectomy. Histological examination demonstrated that the tumor was composed of prominent vasculature and cellular stromal around vessels. Mitotic activity was absent. Both vascular and stromal cells showed diffusely expressed CD56 and chromogranin A. Stromal cells also expressed actin, SMA, and desmin, but not CK or HMB45. The pathological diagnosis was LANT of the myometrium. Follow up reported no evidence of recurrence three months after surgery.Conclusion: LANT is a possible new disease entity. LANT is a dimorphic tumor consisting of smooth muscle and neurosecretory phenotype cells surrounding intratumoral vessels. Surgery may be the best treatment, resulting in good prognosis.

Leiomyomatoid angiomatous neuroendocrine tumor of the myometrium

Department of Pathology, Fuxing Hospital, Capital Medical University, Beijing 100038,

University Health Science Center, Beijing 100191,

Department of Neurosurgery, Beijing Charity Hospital, China Rehabilitation Research Centre, Capital Medical University School of Rehabilitation Medicine, Beijing 100068,

Asian Biomedicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

{"article-title":"Leiomyomatoid angiomatous neuroendocrine tumor of the myometrium"}

Background: Only a few cases of Leiomyomatoid angiomatous neuroendocrine tumor (LANT) have been reported in the literature. Our case adds clinical,...

Leiomyomatoid angiomatous neuroendocrine tumor of the myometrium

Article Category: Clinical report

Published Online: Feb 04, 2017

Page range: 443 - 448

DOI: https://doi.org/10.5372/1905-7415.0703.198

© 2017

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.