<abstract xmlns="http://www.w3.org/1999/xhtml"> Background: Recognition of hypertriglyceridemia is critical for the diagnosis of hyperlipidemic pancreatitis (HLP) and the selection and evaluation of therapy.Objective: Investigate metabolic profiling technologies for identifying novel biomarkers and pathways activated in HLP.Methods: Blood and urine samples were obtained from 24 patients and 39 healthy people. A gas chromatography and mass spectrometry was employed to study the metabolic profile in HLP and healthy groups. Functional pathway trend analysis using multivariate statistical analysis was performed.Results: HLP patients could be precisely distinguished from the healthy controls. In the patient, levels of aconitate, citrate, hippurate, p-hydroxyphenylacetate and p-hydroxyphenylpopionic acid were decreased, while levels of tryptophan, tyrosine, tyramine,16-hexadecanoic acid, and 18-octadecanoic acid were increased. The change of energy metabolism-related mechanisms, fatty acid metabolism, gut microbiota metabolism, and metabolism of tyrosine could be used to distinguish HLP patients.Conclusions: Novel biomarkers could be identified by application of metabolomics. Metabolic profiling was useful for studies of pathogenesis of HLP.</abstract>

Background: Recognition of hypertriglyceridemia is critical for the diagnosis of hyperlipidemic pancreatitis (HLP) and the selection and evaluation of therapy.Objective: Investigate metabolic profiling technologies for identifying novel biomarkers and pathways activated in HLP.Methods: Blood and urine samples were obtained from 24 patients and 39 healthy people. A gas chromatography and mass spectrometry was employed to study the metabolic profile in HLP and healthy groups. Functional pathway trend analysis using multivariate statistical analysis was performed.Results: HLP patients could be precisely distinguished from the healthy controls. In the patient, levels of aconitate, citrate, hippurate, p-hydroxyphenylacetate and p-hydroxyphenylpopionic acid were decreased, while levels of tryptophan, tyrosine, tyramine,16-hexadecanoic acid, and 18-octadecanoic acid were increased. The change of energy metabolism-related mechanisms, fatty acid metabolism, gut microbiota metabolism, and metabolism of tyrosine could be used to distinguish HLP patients.Conclusions: Novel biomarkers could be identified by application of metabolomics. Metabolic profiling was useful for studies of pathogenesis of HLP.

Novel biomarkers of hyperlipidemic acute pancreatitis: metabolomic identification

Department of Gastroenterology, Shanghai 10th People’s Hospital, Tongji University School of Medicine, Shanghai 200072,

Shanghai Institute for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai 200240,

Department of Gastroenterology , Shanghai 10th People’s Hospital, Tongji University School of Medicine, Shanghai 200072,

Asian Biomedicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Background: Recognition of hypertriglyceridemia is critical for the diagnosis of hyperlipidemic pancreatitis (HLP) and the selection and evaluation of...

Novel biomarkers of hyperlipidemic acute pancreatitis: metabolomic identification

Article Category: Brief communication (Original)

Published Online: Feb 04, 2017

Page range: 765 - 769

DOI: https://doi.org/10.5372/1905-7415.0605.119

Keywords
Blood, hyperlipidemic pancreatitis, metabolism, urine

© 2017

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Novel biomarkers of hyperlipidemic acute pancreatitis: metabolomic identification

Article Category: Brief communication (Original)

Published Online: Feb 04, 2017

Page range: 765 - 769

DOI: https://doi.org/10.5372/1905-7415.0605.119

KeywordsBlood, hyperlipidemic pancreatitis, metabolism, urine

© 2017

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Keywords
Blood, hyperlipidemic pancreatitis, metabolism, urine