<abstract xmlns="http://www.w3.org/1999/xhtml"> Background: Drug resistance to current anti-herpetic drugs has been increasingly reported. Therefore, there is a need for finding new antiviral agents, in particular from natural sources.Objective: In the present study, antiviral activity of subset extracts obtained from aerial parts of Artemisia including A. incana, A. chamaemelifolia, A. campesteris, A. fragrans, A. annua, A. vulgaris, and A. persica were investigated against Herpes Simplex type I (HSV1).Methods: Different concentrations of extracts (400, 200, 100, 50, 25, 12.5, 6.25, and 3.125 μg/mL) were obtained from subset of each plant separately, and used against KOS strain of HSV1 in HeLa cells. After 24 hours incubation, tetrazolium dye (MTT), was added. The dye absorption by viable cells was measured and compared to the positive control (extract-untreated cells) and acyclovir (as anti-viral agent).Results: The extracts obtained from A. annua had the highest antiviral activity while those of A. chamaemelifolia showed the lowest activity.Conclusion: Subset extracts of A. annua may be an appropriate candidate for further development of anti HSV1 infection.</abstract>

Background: Drug resistance to current anti-herpetic drugs has been increasingly reported. Therefore, there is a need for finding new antiviral agents, in particular from natural sources.Objective: In the present study, antiviral activity of subset extracts obtained from aerial parts of Artemisia including A. incana, A. chamaemelifolia, A. campesteris, A. fragrans, A. annua, A. vulgaris, and A. persica were investigated against Herpes Simplex type I (HSV1).Methods: Different concentrations of extracts (400, 200, 100, 50, 25, 12.5, 6.25, and 3.125 μg/mL) were obtained from subset of each plant separately, and used against KOS strain of HSV1 in HeLa cells. After 24 hours incubation, tetrazolium dye (MTT), was added. The dye absorption by viable cells was measured and compared to the positive control (extract-untreated cells) and acyclovir (as anti-viral agent).Results: The extracts obtained from A. annua had the highest antiviral activity while those of A. chamaemelifolia showed the lowest activity.Conclusion: Subset extracts of A. annua may be an appropriate candidate for further development of anti HSV1 infection.

Antiviral activities of aerial subsets of Artemisia species against Herpes Simplex virus type 1 (HSV1) in vitro

Department of Microbiology, Qhaem Medical Center,

Department of Pharmacognosy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad 91775-1365,

Department of Microbiology, Medical school, Hamadan University of Medical Sciences, Hamadan 65178-3-8736,

Biotechnology Research Center and School of Pharmacy, Mashhad University of Medical Sciences, Mashhad 91775-1365,

Asian Biomedicine

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Background: Drug resistance to current anti-herpetic drugs has been increasingly reported. Therefore, there is a need for finding new antiviral agents, in...

Antiviral activities of aerial subsets of Artemisia species against Herpes Simplex virus type 1 (HSV1) in vitro

Article Category: Original article

Published Online: Feb 04, 2017

Page range: 63 - 68

DOI: https://doi.org/10.5372/1905-7415.0501.007

Keywords
Antivirals, Artemisia, asteraceae, herpes simplex

© 2017

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Antiviral activities of aerial subsets of Artemisia species against Herpes Simplex virus type 1 (HSV1) in vitro

Article Category: Original article

Published Online: Feb 04, 2017

Page range: 63 - 68

DOI: https://doi.org/10.5372/1905-7415.0501.007

KeywordsAntivirals, Artemisia, asteraceae, herpes simplex

© 2017

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

Keywords
Antivirals, Artemisia, asteraceae, herpes simplex