Pneumococcal Meningitis and Its Sequelae – A Devastating CNS Disease

Patient No.	Sex	Age at first scan	No. of scans	Age at last scan	Follow-up period on MRI	Meningeal enhancement	Meningeal empyema(s)	Vasculitis with brain infarcts	Cavities	Hydrocephalus	Surgical, neurological and developmental sequelae
1	M	1st month	3	11 years	11 years	+	−	−	−	+	Epilepsy; CP (marked quadriplegic paresis); severe intellectual disability; PEG; lying obese patient; severe scoliosis; history of aspiration pneumonias
2	M	4/12	1	−	0	+	−	−	+	−	Died
3	F	6/12	1	−	0	+	+	+	+	+	8 months post-IPD: delayed psychomotor development, left peripheral facial paresis, reduced muscle tone, discrete left hemiparesis, does not focus the eyes
4	M	7/12	2	31/12	2 years	+	−	+	+	−	4 years post-IPD: epilepsy with focal seizures, CP (mild right hemiparesis)
5	M	8/12	5	6 years	5 years	+	+	+	−	+	6 years post-IPD: reduced muscle tone, discrete paresis of left hand, severe intellectual disability; history of ventriculoperitoneal shunt and revisions
6	M	13/12	2	14/12	4 weeks	+	+	−	−	−	lost from further follow-up
7	M	15/12	3	19/12	4/12	+	−	+	+	+	lost from further follow-up
8	F	16/12	2	16/12	11 days	+	−	+	−	+	2 years post-IPD: moderate left spastic paresis leg>hand; history of trepanobiopsy for chronic hygromas–haematomas
9	M	4 years	8	16 years	12 years	+	−	+	+	+	Coma, then vegetative state; severe spastic quadriplegic paresis; lying patient; history of, ventriculoperitoneal shunt and revisions and of aspiration pneumonias
10	M	5 years	1	−	0	+	+	+	−	−	Lost from follow-up

Publication timeframe:: Volume Open
Journal Subjects:: Medicine, Clinical Medicine, Pediatrics and Juvenile Medicine, Paediatric Haematology and Oncology, Public Health