This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Yew YW, Thyssen JP, Silverberg JI. A systematic review and meta-analysis of the regional and age-related differences in atopic dermatitis clinical characteristics. J Am Acad Dermatol. 2019;80(2):390–401. doi: 10.1016/j.jaad.2018.09.035YewYWThyssenJPSilverbergJIA systematic review and meta-analysis of the regional and age-related differences in atopic dermatitis clinical characteristics201980239040110.1016/j.jaad.2018.09.03530287309Open DOISearch in Google Scholar
Roduit C, Frei R, Depner M, Karvonen AM, Renz H, Braun-Fahrländer C, et al. Phenotypes of atopic dermatitis depending on the timing of onset and progression in childhood. JAMA Pediatr. 2017;171(7):655–62. doi: 10.1001/jamapediatrics.2017.0556RoduitCFreiRDepnerMKarvonenAMRenzHBraun-FahrländerCPhenotypes of atopic dermatitis depending on the timing of onset and progression in childhood201717176556210.1001/jamapediatrics.2017.0556571033728531273Open DOISearch in Google Scholar
Sybilski AJ, Raciborski F, Lipiec A, Tomaszewska A, Lusawa A, Samel-Kowalik P, et al. Atopic dermatitis is a serious health problem in Poland. Epidemiology studies based on the ECAP study. Postepy Dermatol Alergol. 2015;32(1):1–10. doi: 10.5114/pdia.2014.40935SybilskiAJRaciborskiFLipiecATomaszewskaALusawaASamel-KowalikPAtopic dermatitis is a serious health problem in Poland. Epidemiology studies based on the ECAP study201532111010.5114/pdia.2014.40935436000025821420Open DOISearch in Google Scholar
Rønnstad ATM, Halling-Overgaard AS, Hamann CR, Skov L, Egeberg A, Thyssen JP. Association of atopic dermatitis with depression, anxiety, and suicidal ideation in children and adults: a systematic review and meta-analysis. J Am Acad Dermatol. 2018;79(3):448–56.e30. doi: 10.1016/j.jaad.2018.03.017RønnstadATMHalling-OvergaardASHamannCRSkovLEgebergAThyssenJPAssociation of atopic dermatitis with depression, anxiety, and suicidal ideation in children and adults: a systematic review and meta-analysis201879344856.e3010.1016/j.jaad.2018.03.01730119868Open DOISearch in Google Scholar
Yang EJ, Beck KM, Sekhon S, Bhutani T, Koo J. The impact of pediatric atopic dermatitis on families: a review. Pediatr Dermatol. 2019;36(1):66–71. doi: 10.1111/pde.13727YangEJBeckKMSekhonSBhutaniTKooJThe impact of pediatric atopic dermatitis on families: a review2019361667110.1111/pde.1372730556595Open DOISearch in Google Scholar
Moyle M, Cevikbas F, Harden JL, Guttman-Yassky E. Understanding the immune landscape in atopic dermatitis: The era of biologics and emerging therapeutic approaches. Exp Dermatol. 2019;28(7):756–68. doi: 10.1111/exd.13911MoyleMCevikbasFHardenJLGuttman-YasskyEUnderstanding the immune landscape in atopic dermatitis: The era of biologics and emerging therapeutic approaches20192877566810.1111/exd.13911685048030825336Open DOISearch in Google Scholar
Suárez-Fariñas M, Dhingra N, Gittler J, Shemer A, Cardinale I, de Guzman Strong C, et al. Intrinsic atopic dermatitis shows similar TH2 and higher TH17 immune activation compared with extrinsic atopic dermatitis. J Allergy Clin Immunol. 2013;132(2):361–70. doi: 10.1016/j.jaci.2013.04.046Suárez-FariñasMDhingraNGittlerJShemerACardinaleIde Guzman StrongCIntrinsic atopic dermatitis shows similar TH2 and higher TH17 immune activation compared with extrinsic atopic dermatitis201313223617010.1016/j.jaci.2013.04.046399124023777851Open DOISearch in Google Scholar
Osinka K, Dumycz K, Kwiek B, Feleszko W. Novel therapeutic approaches to atopic dermatitis. Arch Immunol Ther Exp (Warsz). 2018;66(3):171–81. doi: 10.1007/s00005-017-0487-1OsinkaKDumyczKKwiekBFeleszkoWNovel therapeutic approaches to atopic dermatitis20186631718110.1007/s00005-017-0487-128861617Open DOISearch in Google Scholar
Brunner PM, Israel A, Zhang N, Leonard A, Wen HC, Huynh T, et al. Early-onset pediatric atopic dermatitis is characterized by TH2/TH17/TH22-centered inflammation and lipid alterations. J Allergy Clin Immunol. 2018;141(6):2094–106. doi: 10.1016/j.jaci.2018.02.040BrunnerPMIsraelAZhangNLeonardAWenHCHuynhTEarly-onset pediatric atopic dermatitis is characterized by TH2/TH17/TH22-centered inflammation and lipid alterations20181416209410610.1016/j.jaci.2018.02.04029731129Open DOISearch in Google Scholar
Nguyen HL, Anderson KR, Tollefson MM. New and emerging therapies for pediatric atopic dermatitis. Paediatr Drugs. 2019;21(4):239–60. doi: 10.1007/s40272-019-00342-wNguyenHLAndersonKRTollefsonMMNew and emerging therapies for pediatric atopic dermatitis20192142396010.1007/s40272-019-00342-w31364023Open DOISearch in Google Scholar
Seo E, Yoon J, Jung S, Lee J, Lee BH, Yu J. Phenotypes of atopic dermatitis identified by cluster analysis in early childhood. J Dermatol. 2019;46(2):117–23. doi: 10.1111/1346-8138.14714SeoEYoonJJungSLeeJLeeBHYuJPhenotypes of atopic dermatitis identified by cluster analysis in early childhood20194621172310.1111/1346-8138.1471430520087Open DOISearch in Google Scholar
Eyerich K, Novak N. Immunology of atopic eczema: overcoming the Th1/Th2 paradigm. Allergy. 2013;68(8):974–82. doi: 10.1111/all.12184EyerichKNovakNImmunology of atopic eczema: overcoming the Th1/Th2 paradigm20136889748210.1111/all.1218423889510Open DOISearch in Google Scholar
Glines KR, Stiff KM, Freeze M, Cline A, Stowd LC, Feldman SR. An update on the topical and oral therapy options for treating pediatric atopic dermatitis. Expert Opin Pharmacother. 2019;20(5):621–29. doi: 1.1080/14656566.2018.1561868GlinesKRStiffKMFreezeMClineAStowdLCFeldmanSRAn update on the topical and oral therapy options for treating pediatric atopic dermatitis2019205621291.1080/14656566.2018.1561868Open DOISearch in Google Scholar
Bos B, Antonescu I, Osinga H, Veenje S, de Jong K, de Vries TW. Corticosteroid phobia (corticophobia) in parents of young children with atopic dermatitis and their health care providers. Pediatr Dermatol. 2019;36(1):100–4. doi: 10.1111/pde.13698BosBAntonescuIOsingaHVeenjeSde JongKde VriesTWCorticosteroid phobia (corticophobia) in parents of young children with atopic dermatitis and their health care providers2019361100410.1111/pde.1369830338542Open DOISearch in Google Scholar
Alexander T, Maxim E, Cardwell LA, Chawla A, Feldman SR. Prescriptions for atopic dermatitis: oral corticosteroids remain commonplace. J Dermatolog Treat. 2018;29(3):238–40. doi: 10.1080/09546634.2017.1365112AlexanderTMaximECardwellLAChawlaAFeldmanSRPrescriptions for atopic dermatitis: oral corticosteroids remain commonplace20182932384010.1080/09546634.2017.136511228789575Open DOISearch in Google Scholar
Sarıcaoğlu H, Yazici S, Zorlu Ö, Bülbül Başkan E, Aydoğan K. Cyclosporine-A for severe childhood atopic dermatitis: clinical experience on efficacy and safety profile. Turk J Med Sci. 2018;48(5):933–8. doi: 10.3906/sag-1711-7SarıcaoğluHYaziciSZorluÖBülbül BaşkanEAydoğanKCyclosporine-A for severe childhood atopic dermatitis: clinical experience on efficacy and safety profile2018485933810.3906/sag-1711-730384556Open DOISearch in Google Scholar
Taieb Y, Baum S, Ben Amitai D, Barzilai A, Greenberger S. The use of methotrexate for treating childhood atopic dermatitis: A multi-center retrospective study. J Dermatolog Treat. 2019;30(3):240–4. doi: 10.1080/09546634.2018.1508816TaiebYBaumSBen AmitaiDBarzilaiAGreenbergerSThe use of methotrexate for treating childhood atopic dermatitis: A multi-center retrospective study2019303240410.1080/09546634.2018.150881630109960Open DOISearch in Google Scholar
Klasa B, Cichocka-Jarosz E. Aktualne możliwości leczenia atopowego zapalenia skóry z perspektywy pediatry. The current possibilities of treatment for atopic dermatitis from pediatrician's perspective. Przegląd Lekarski. 2017;74(8):399–404.KlasaBCichocka-JaroszEAktualne możliwości leczenia atopowego zapalenia skóry z perspektywy pediatryThe current possibilities of treatment for atopic dermatitis from pediatrician's perspective2017748399404Search in Google Scholar
Brunner PM, Guttman-Yassky E, Leung DY. The immunology of atopic dermatitis and its reversibility with broad-spectrum and targeted therapies. J Allergy Clin Immunol. 2017;139(4S):S65–76. doi: 10.1016/j.jaci.2017.01.011BrunnerPMGuttman-YasskyELeungDYThe immunology of atopic dermatitis and its reversibility with broad-spectrum and targeted therapies20171394SS657610.1016/j.jaci.2017.01.011540570228390479Open DOISearch in Google Scholar
Simpson EL, Flohr C, Eichenfield LF, Bieber T, Sofen H, Taïeb A, et al. Efficacy and safety of lebrikizumab (an anti-IL-13 monoclonal antibody) in adults with moderate-to-severe atopic dermatitis inadequately controlled by topical corticosteroids: a randomized, placebo-controlled phase II trial (TREBLE). J Am Acad Dermatol. 2018;78(5):863.e11–71.e11. doi: 10.1016/j.jaad.2018.01.017SimpsonELFlohrCEichenfieldLFBieberTSofenHTaïebAEfficacy and safety of lebrikizumab (an anti-IL-13 monoclonal antibody) in adults with moderate-to-severe atopic dermatitis inadequately controlled by topical corticosteroids: a randomized, placebo-controlled phase II trial (TREBLE)2018785863.e1171.e1110.1016/j.jaad.2018.01.01729353026Open DOISearch in Google Scholar
Hamilton JD, Ungar B, Guttman-Yassky E. Drug evaluation review: dupilumab in atopic dermatitis. Immunotherapy. 2015;7(10):1043–58. doi: 10.2217/imt.15.69HamiltonJDUngarBGuttman-YasskyEDrug evaluation review: dupilumab in atopic dermatitis201571010435810.2217/imt.15.6926598956Open DOISearch in Google Scholar
Leung DY, Guttman-Yassky E. Deciphering the complexities of atopic dermatitis: shifting paradigms in treatment approaches. J Allergy Clin Immunol. 2014;134(4):769–79. doi: 10.1016/j.jaci.2014.08.008LeungDYGuttman-YasskyEDeciphering the complexities of atopic dermatitis: shifting paradigms in treatment approaches201413447697910.1016/j.jaci.2014.08.008Open DOISearch in Google Scholar
Danso MO, van Drongelen V, Mulder A, van Esch J, Scott H, van Smeden J, et al. TNF-α and Th2 cytokines induce atopic dermatitis-like features on epidermal differentiation proteins and stratum corneum lipids in human skin equivalents. J Invest Dermatol. 2014;134(7):1941–50. doi: 10.1038/jid.2014.83DansoMOvan DrongelenVMulderAvan EschJScottHvan SmedenJTNF-α and Th2 cytokines induce atopic dermatitis-like features on epidermal differentiation proteins and stratum corneum lipids in human skin equivalents2014134719415010.1038/jid.2014.83Open DOISearch in Google Scholar
European Medicines Agency. 2018. Available from: https://www.ema.europa.eu/en/documents/pip-decision/p/0158/2018-ema-decision-15-june-2018-acceptance-modification-agreed-paediatric-investigation-plan_en.pdf.2018Available from: https://www.ema.europa.eu/en/documents/pip-decision/p/0158/2018-ema-decision-15-june-2018-acceptance-modification-agreed-paediatric-investigation-plan_en.pdf.Search in Google Scholar
REGENERON. FDA approves Dupixent® (dupilumab) for moderate-to-severe atopic dermatitis in adolescents. Tarrytown, NY, Cambridge, MA: PRNewswire. SOURCE Regeneron Pharmaceuticals, Inc.; 2019 March 11. Available from: https://newsroom.regeneron.com/news-releases/news-release-details/fda-approves-dupixentr-dupilumab-moderate-severe-atopicREGENERONTarrytown, NY, Cambridge, MAPRNewswire. SOURCE Regeneron Pharmaceuticals, Inc.2019March11Available from: https://newsroom.regeneron.com/news-releases/news-release-details/fda-approves-dupixentr-dupilumab-moderate-severe-atopicSearch in Google Scholar
Wollenberg A, Howell MD, Guttman-Yassky E, Silverberg JI, Kell C, Ranade K, et al. Treatment of atopic dermatitis with tralokinumab, an anti-IL-13 mAb. J Allergy Clin Immunol. 2019;143(1):135–41. doi: 10.1016/j.jaci.2018.05.029WollenbergAHowellMDGuttman-YasskyESilverbergJIKellCRanadeKTreatment of atopic dermatitis with tralokinumab, an anti-IL-13 mAb201914311354110.1016/j.jaci.2018.05.029Open DOISearch in Google Scholar
Wenzel S, Wilbraham D, Fuller R, Getz EB, Longphre M. Effect of an interleukin-4 variant on late phase asthmatic response to allergen challenge in asthmatic patients: results of two phase 2a studies. Lancet. 2007;370(9596):1422–31. doi: 10.1016/S0140-6736(07)61600-6WenzelSWilbrahamDFullerRGetzEBLongphreMEffect of an interleukin-4 variant on late phase asthmatic response to allergen challenge in asthmatic patients: results of two phase 2a studies2007370959614223110.1016/S0140-6736(07)61600-6Open DOISearch in Google Scholar
Kunsleben N, Rüdrich U, Gehring M, Novak N, Kapp A, Raap U. IL-31 induces chemotaxis, calcium mobilization, release of reactive oxygen species, and CCL26 in eosinophils, which are capable to release IL-31. J Invest Dermatol. 2015;135(7):1908–11. doi: 10.1038/jid.2015.106KunslebenNRüdrichUGehringMNovakNKappARaapUIL-31 induces chemotaxis, calcium mobilization, release of reactive oxygen species, and CCL26 in eosinophils, which are capable to release IL-312015135719081110.1038/jid.2015.10625789701Open DOISearch in Google Scholar
Hänel KH, Pfaff CM, Cornelissen C, Amann PM, Marquardt Y, Czaja K, et al. Control of the physical and antimicrobial skin barrier by an IL-31-IL-1 signaling network. J Immunol. 2016;196(8):3233–44. doi: 10.4049/jimmunol.1402943HänelKHPfaffCMCornelissenCAmannPMMarquardtYCzajaKControl of the physical and antimicrobial skin barrier by an IL-31-IL-1 signaling network2016196832334410.4049/jimmunol.140294326944931Open DOISearch in Google Scholar
Kabashima K, Furue M, Hanifin JM, Pulka G, Wollenberg A, Galus R, et al. Nemolizumab in patients with moderate-to-severe atopic dermatitis: Randomized, phase II, long-term extension study. J Allergy Clin Immunol. 2018;142(4):1121.e7–30.e7. doi: 10.1016/j.jaci.2018.03.018KabashimaKFurueMHanifinJMPulkaGWollenbergAGalusRNemolizumab in patients with moderate-to-severe atopic dermatitis: Randomized, phase II, long-term extension study201814241121.e730.e710.1016/j.jaci.2018.03.01829753033Open DOISearch in Google Scholar
Shroff A, Guttman-Yassky E. Successful use of ustekinumab therapy in refractory severe atopic dermatitis. JAAD Case Rep. 2014;1(1):25–6. doi: 10.1016/j.jdcr.2014.10.007ShroffAGuttman-YasskyESuccessful use of ustekinumab therapy in refractory severe atopic dermatitis20141125610.1016/j.jdcr.2014.10.007480255327075132Open DOISearch in Google Scholar
Guttman-Yassky E, Silverberg JI, Nemoto O, Forman SB, Wilke A, Prescilla R, et al. Baricitinib in adult patients with moderate-to-severe atopic dermatitis: a phase 2 parallel, double-blinded, randomized placebo-controlled multiple-dose study. J Am Acad Dermatol. 2019;80(4):913.e9–21.e9. doi: 10.1016/j.jaad.2018.01.018Guttman-YasskyESilverbergJINemotoOFormanSBWilkeAPrescillaRBaricitinib in adult patients with moderate-to-severe atopic dermatitis: a phase 2 parallel, double-blinded, randomized placebo-controlled multiple-dose study2019804913.e921.e910.1016/j.jaad.2018.01.01829410014Open DOISearch in Google Scholar
Guttman-Yassky E, Thaçi D, Pangan AL, Hong HC, Papp KA, Reich K, et al. Upadacitinib in adults with moderate to severe atopic dermatitis: 16-week results from a randomized, placebo-controlled trial. J Allergy Clin Immunol. 2020;145(3):877–84. doi: 10.1016/j.jaci.2019.11.025.Guttman-YasskyEThaçiDPanganALHongHCPappKAReichKUpadacitinib in adults with moderate to severe atopic dermatitis: 16-week results from a randomized, placebo-controlled trial202014538778410.1016/j.jaci.2019.11.02531786154Open DOISearch in Google Scholar
Gooderham MJ, Forman SB, Bissonnette R, Beebe JS, Zhang W, Banfield C, et al. Efficacy and safety of oral Janus kinase 1 inhibitor abrocitinib for patients with atopic dermatitis: a phase 2 randomized clinical trial. JAMA Dermatol. 2019;155(12):1371–9. doi: 10.1001/jamadermatol.2019.2855GooderhamMJFormanSBBissonnetteRBeebeJSZhangWBanfieldCEfficacy and safety of oral Janus kinase 1 inhibitor abrocitinib for patients with atopic dermatitis: a phase 2 randomized clinical trial2019155121371910.1001/jamadermatol.2019.2855677722631577341Open DOISearch in Google Scholar
Kim BS, Howell MD, Sun K, Papp K, Nasir A, Kuligowski ME; INCB 18424-206 Study Investigators. Treatment of atopic dermatitis with ruxolitinib cream (JAK1/JAK2 inhibitor) or triamcinolone cream. J Allergy Clin Immunol. 2020;145(2):572–82. doi: 10.1016/j.jaci.2019.08.042KimBSHowellMDSunKPappKNasirAKuligowskiMEINCB 18424-206 Study InvestigatorsTreatment of atopic dermatitis with ruxolitinib cream (JAK1/JAK2 inhibitor) or triamcinolone cream202014525728210.1016/j.jaci.2019.08.04231629805Open DOISearch in Google Scholar
Bissonnette R, Maari C, Forman S, Bhatia N, Lee M, Fowler J, et al. The oral Janus kinase/spleen tyrosine kinase inhibitor ASN002 demonstrates efficacy and improves associated systemic inflammation in patients with moderate-to-severe atopic dermatitis: results from a randomized double-blind placebo-controlled study. Br J Dermatol. 2019;181(4):733–42. doi: 10.1111/bjd.17932BissonnetteRMaariCFormanSBhatiaNLeeMFowlerJThe oral Janus kinase/spleen tyrosine kinase inhibitor ASN002 demonstrates efficacy and improves associated systemic inflammation in patients with moderate-to-severe atopic dermatitis: results from a randomized double-blind placebo-controlled study201918147334210.1111/bjd.17932685060530919407Open DOISearch in Google Scholar
Nakagawa H, Nemoto O, Yamada H, Nagata T, Ninomiya N. Phase 1 studies to assess the safety, tolerability and pharmacokinetics of JTE-052 (a novel Janus kinase inhibitor) ointment in Japanese healthy volunteers and patients with atopic dermatitis. J Dermatol. 2018;45(6):701–9. doi: 10.1111/1346-8138.14322NakagawaHNemotoOYamadaHNagataTNinomiyaNPhase 1 studies to assess the safety, tolerability and pharmacokinetics of JTE-052 (a novel Janus kinase inhibitor) ointment in Japanese healthy volunteers and patients with atopic dermatitis2018456701910.1111/1346-8138.14322600168729665062Open DOISearch in Google Scholar
Paller AS, Tom WL, Lebwohl MG, Blumenthal RL, Boguniewicz M, Call RS, et al. Efficacy and safety of crisaborole ointment, a novel, nonsteroidal phosphodiesterase 4 (PDE4) inhibitor for the topical treatment of atopic dermatitis (AD) in children and adults. J Am Acad Dermatol. 2016;75(3):494.e6–503.e6. doi: 10.1016/j.jaad.2016.05.046. Erratum in: J Am Acad Dermatol. 2017;76(4):777PallerASTomWLLebwohlMGBlumenthalRLBoguniewiczMCallRSEfficacy and safety of crisaborole ointment, a novel, nonsteroidal phosphodiesterase 4 (PDE4) inhibitor for the topical treatment of atopic dermatitis (AD) in children and adults2016753494.e6503.e610.1016/j.jaad.2016.05.046Erratum in: J Am Acad Dermatol. 2017;76(4):77727417017Open DOISearch in Google Scholar
Ohba F, Nomoto M, Hojo S, Akama H. Safety, tolerability and pharmacokinetics of a novel phosphodiesterase inhibitor, E6005 ointment, in healthy volunteers and in patients with atopic dermatitis. J Dermatolog Treat. 2016;27(3):241–6. doi: 10.3109/09546634.2015.1093587OhbaFNomotoMHojoSAkamaHSafety, tolerability and pharmacokinetics of a novel phosphodiesterase inhibitor, E6005 ointment, in healthy volunteers and in patients with atopic dermatitis2016273241610.3109/09546634.2015.109358726581111Open DOISearch in Google Scholar
Czarnowicki T, He H, Krueger JG, Guttman-Yassky E. Atopic dermatitis endotypes and implications for targeted therapeutics. J Allergy Clin Immunol. 2019;143(1):1–11. doi: 10.1016/j.jaci.2018.10.032CzarnowickiTHeHKruegerJGGuttman-YasskyEAtopic dermatitis endotypes and implications for targeted therapeutics2019143111110.1016/j.jaci.2018.10.03230612663Open DOISearch in Google Scholar