<abstract xmlns="http://www.w3.org/1999/xhtml"><p> Three groups of caged bees were fed with sugar syrup (the control), sugar syrup supplemented with amphotericin B (AmB) in a dose of 0.5 mg/ml, and sugar syrup with AmB in a dose of 0.25 mg/ ml. Amphotericin B shortened the life span of the bees and reduced the level of global DNA methylation compared to the control, however, it increased the body-surface protein concentrations. In the hindguts of the bees, there were found AmB deposits. Honeybees appear to be a useful model for studying the side effects of anti-fungal AmB therapy. Among other things, epigenetic changes and senescence acceleration are considered to be the side effects of the therapy.</p></abstract>

Three groups of caged bees were fed with sugar syrup (the control), sugar syrup supplemented with amphotericin B (AmB) in a dose of 0.5 mg/ml, and sugar syrup with AmB in a dose of 0.25 mg/ ml. Amphotericin B shortened the life span of the bees and reduced the level of global DNA methylation compared to the control, however, it increased the body-surface protein concentrations. In the hindguts of the bees, there were found AmB deposits. Honeybees appear to be a useful model for studying the side effects of anti-fungal AmB therapy. Among other things, epigenetic changes and senescence acceleration are considered to be the side effects of the therapy.

The Effect of Amphotericin B on the Lifespan, Body-surface Protein Concentrations, and DNA Methylation Levels of Honey Bees (Apis mellifera)

Department of Biological Basis of Animal Production, Faculty of Biology and Animal Breeding, University of Life Sciences in Lublin, Akademicka 13, 20-950 Lublin, Poland

Department of Biophysics, University of Life Sciences in Lublin, Akademicka 13, 20-950 Lublin, Poland

Department of Zoology, Institute of Biology and Biochemistry, Faculty of Biology and Biotechnology, Akademicka 19, 20-033 Lublin, Poland

Laboratory of Assessment of Grain and Oil Materials Quality, Institute of Agrophysics, Polish Academy of Sciences in Lublin, Doświadczalna 4, P.O. Box 201, 20-290 Lublin, Poland

Journal of Apicultural Science

Three groups of caged bees were fed with sugar syrup (the control), sugar syrup supplemented with amphotericin B (AmB) in a dose of 0.5 mg/ml, and sugar syrup...

The Effect of Amphotericin B on the Lifespan, Body-surface Protein Concentrations, and DNA Methylation Levels of Honey Bees (Apis mellifera)

Published Online: Jan 12, 2013

Page range: 107 - 113

DOI: https://doi.org/10.2478/v10289-012-0028-4

This content is open access.