<abstract xmlns="http://www.w3.org/1999/xhtml"><p> The authors present a case of a man with urticaria pigmentosa and acquired immunodeficiency syndrome - AIDS. The patient was diagnosed as HIV (human immunodeficiency virus) - positive in the year 2000, at the Infectious Diseases Clinic, Clinical Center of Vojvodina in Novi Sad. Urticaria pigmentosa was detected (nine years later) during a dermatological examination at the Dermatovenerology Department of the Outpatient Clinic, Clinical Center of Vojvodina. Urticaria pigmentosa is the most common manifestation of cutaneous mastocytosis. The patient was taking long term antiviral therapy for several years. Approximately 2 years after the onset of urticaria pigmentosa, this patient developed septicemia and ascites along with hepatosplenomegaly, liver damage, chronic cholecystitis, leukopenia, thrombocytopenia and relative eosinophilia. The patient had increased total serum IgE levels and tested positive for 5-hydroxyindoleacetic acid in a 24-hour urine test from the very beginning of urticaria pigmnentosa and during the course of his illness. Immunohistochemical results of dermal biopsy of the affected area confirmed the diagnosis of urticaria pigmentosa. Histology findings confirmed presence of typical dermal mast cell infiltrates with distinct oval and spindle granules that were CD117+ and CD1a-. Systemic mastocytosis was excluded by liver and bone marrow biopsies. To our knowledge, we present the third case of associated mastocytosis and acquired immunodeficiency syndrome published in world literature so far, in order to indicate the possible interaction between HIV infection and mast cells.</p></abstract>

The authors present a case of a man with urticaria pigmentosa and acquired immunodeficiency syndrome - AIDS. The patient was diagnosed as HIV (human immunodeficiency virus) - positive in the year 2000, at the Infectious Diseases Clinic, Clinical Center of Vojvodina in Novi Sad. Urticaria pigmentosa was detected (nine years later) during a dermatological examination at the Dermatovenerology Department of the Outpatient Clinic, Clinical Center of Vojvodina. Urticaria pigmentosa is the most common manifestation of cutaneous mastocytosis. The patient was taking long term antiviral therapy for several years. Approximately 2 years after the onset of urticaria pigmentosa, this patient developed septicemia and ascites along with hepatosplenomegaly, liver damage, chronic cholecystitis, leukopenia, thrombocytopenia and relative eosinophilia. The patient had increased total serum IgE levels and tested positive for 5-hydroxyindoleacetic acid in a 24-hour urine test from the very beginning of urticaria pigmnentosa and during the course of his illness. Immunohistochemical results of dermal biopsy of the affected area confirmed the diagnosis of urticaria pigmentosa. Histology findings confirmed presence of typical dermal mast cell infiltrates with distinct oval and spindle granules that were CD117+ and CD1a-. Systemic mastocytosis was excluded by liver and bone marrow biopsies. To our knowledge, we present the third case of associated mastocytosis and acquired immunodeficiency syndrome published in world literature so far, in order to indicate the possible interaction between HIV infection and mast cells.

Urticaria pigmentosa in a patient with acquired immunodeficiency syndrome – a case report / Urtikarija pigmentoza kod obolelog od sindroma stečene imunodeficijencije – prikaz slučaja

Clinic of Dermatovenereology Diseases, Clinical Center of Vojvodina, Novi Sad, Republic of Serbia

Infectious Diseases Clinic, Clinical Center of Vojvodina, Novi Sad, Republic of Serbia

Center of Pathology and Histology, Clinical Center of Vojvodina, Novi Sad, Republic of Serbia

Serbian Journal of Dermatology and Venereology

The authors present a case of a man with urticaria pigmentosa and acquired immunodeficiency syndrome - AIDS. The patient was diagnosed as HIV (human...

Urticaria pigmentosa in a patient with acquired immunodeficiency syndrome – a case report / Urtikarija pigmentoza kod obolelog od sindroma stečene imunodeficijencije – prikaz slučaja

Published Online: Feb 12, 2013

Page range: 113 - 120

DOI: https://doi.org/10.2478/v10249-011-0043-7

Keywords
Urticaria Pigmentosa, HIV, Acquired Immunodeficiency Syndrome, Comorbidity

This content is open access.

Urticaria pigmentosa in a patient with acquired immunodeficiency syndrome – a case report / Urtikarija pigmentoza kod obolelog od sindroma stečene imunodeficijencije – prikaz slučaja

Published Online: Feb 12, 2013

Page range: 113 - 120

DOI: https://doi.org/10.2478/v10249-011-0043-7

KeywordsUrticaria Pigmentosa, HIV, Acquired Immunodeficiency Syndrome, Comorbidity

This content is open access.

Keywords
Urticaria Pigmentosa, HIV, Acquired Immunodeficiency Syndrome, Comorbidity