Clinical Laboratory Method for Detection of IGHV Mutation Status in Patients with CLL Validated by Igblast and IMGT/V-QUEST

Shanafelt TD. Predicting clinical outcome in CLL: how and why. Hematology. Am Soc Hematol Educ Program. 2009:421-9.10.1182/asheducation-2009.1.42120008228Search in Google Scholar

Hallek M, German CLL Study Group, 2008. Prognostic factors in chronic lymphocytic leukemia. Ann Oncol. 2008; Suppl.4: iv51-iv53.10.1093/annonc/mdn19618519404Search in Google Scholar

Van Dongen, JJM, Langerak AW, Bruggemenn M, Evans PAS, Hummel M et al. Design and standardization of PCR primers and protocols for detection ov clonal immunoglobulin and T-cell receptor gene recombinations i suspect lymphorpoliferations: Report of the BIOMED-2 concerted action BMH4-CT98-3936. Leukemia 2003; 17: 2257-2317.10.1038/sj.leu.240320214671650Search in Google Scholar

Szankasi P, Bahler DW. Clinical laboratory analysis of immunoglobulin heavy chain variable region genes for chronic lymphocytic leukemia prognosis. J Molec Diagn. 2010; 12: 244-249.10.2353/jmoldx.2010.090091287173220110453Search in Google Scholar

Tobin G, Thunberg U, Karlsson K, Murray F, Laurell A, et al. Subsets with restricted immunoglobulin gene rearrangements features indicate a role of antigen selection in the development of chronic lymphocytic leukemia. Blood 2004; 104: 2879-2885.10.1182/blood-2004-01-013215217826Search in Google Scholar

Hamblin TJ, Davis Z, Gardiner A, Oscier DG, Stevenson FK. Non-mutated Ig VH genes are associated with a more aggressive form of chronic lymphocytic leukemia. Blood 1999; 94: 1848-1854.10.1182/blood.V94.6.1848Search in Google Scholar

Giudicelli V, Chaume D, Lefranc MP. IMGT/V-QUEST, an integrated software program for immunoglobulin and T cell receptor V-J and V-D-J rearrangement analysis. Nucleic Acid Res. 2004; 32: W435-W440.10.1093/nar/gkh41244155015215425Search in Google Scholar

Ghia P, Stamatopoulos K, Belessi C, Moreno C, Stilgenbauer S, et al.: ERIC recommendations on IGHV gene mutational status analysis in chronic lymphocytic leukemia. Leukemia 2007; 21: 1-310.1038/sj.leu.240445717167526Search in Google Scholar

Pekova S, Baran-Marszak F, Schwarz J, Matoska V. Mutated or non-mutated? Which database to choose when determinig the IgVH mutational status in chronic lymphocytic leukemia? Haematologica 2006; 91: e11-e12.Search in Google Scholar

Davi F, Rosenquist R, Ghia P, Belessi C, Stamatopouloss K. Determination of IGHV gene mutational status in chronic lymphocytic leukemia: bioinformatics advances meet clinical needs. Leukemia 2008; 22, 212-214; doi:10.1038/sj.leu.2404969;Search in Google Scholar

Souto-Carneiro MM, Krenn V, Hermann R, Konig A, Muller-Hermelink HK. IgVH genes from different anatomical regions, with different histopathological patterns of rheumatoid arthritis patient suggest cyclic-reentry of mature synovial B-cells in the hypermutation process. Arthritis Res. 2000; 2: 303-314.10.1186/ar1051781311056671Search in Google Scholar

Pekova S, Markova J, Pajer P, Dvorak M, Cetkovsky, P, Schwarz J. Touch-down reverse transcriptase-PCR detection of IgVH rearrangement and Sybr-green-based real-time RT-PCR quantitation of minimal residual disease in patients with chronic lymphocytic leukemia. Mol Diagn. 2005; 9: 23-34.10.2165/00066982-200509010-0000416035732Search in Google Scholar

Marasca R, Maffei R, Morselli M, Zucchini P, Castelli I, et al. Immunoglobulin mutational status detected through single-round amplification of partial VH region represents a good prognostic marker for clinical outcome in chronic lymphocytic leukemia. J Molec Diagnostics. 2005; 7: 566-574.10.1016/S1525-1578(10)60589-2Search in Google Scholar

Valekova L, Fedorova J, Rumanova S, Stasko J, Flochova E, et al. Gastric MALT lymphoma: the role of flow cytometry. Acta Med Martiniana 2007; 3: 24-28.Search in Google Scholar

Kjarfan-Dabaja MA, Chavez JC, Khorfan KA, Pinilla-Ibarz J. Clinical and therapeutic implications of the mutational status of IGHV in patients with chronic lymphocytic leukemia. Cancer 2008; 13: 898-906.Search in Google Scholar

Shanafelt TD. Predicting clinical outcome in CLL: how and why? Hematology Am Soc Hematol Educ Program. 2009; 421-429.10.1182/asheducation-2009.1.42120008228Search in Google Scholar