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Natural flavonoids as potential multifunctional agents in prevention of diabetic cataract

   | Jun 17, 2011

Alexiou P, Pegklidou K, Chatzopoulou M, Nicolaou I, Demopoulos VJ. (2009). Aldose reductase enzyme and its implication to major health problems of the 21(st) century. Curr Med Chem 16: 734-752.Search in Google Scholar

Amić D, Davidović-Amić D, Beslo D, Rastija V, Lucić B, Trinajstić N. (2007). SAR and QSAR of the antioxidant activity of flavonoids. Curr Med Chem 14: 827-845.Search in Google Scholar

Arts IC, Sesink AL, Faassen-Peters M, Hollman PC. (2004). The type of sugar moiety is a major determinant of the small intestinal uptake and subsequent biliary excretion of dietary quercetin glycosides. Br J Nutr 91: 841-847.Search in Google Scholar

Baynes JW. (1991). Role of oxidative stress in development of complications in diabetes. Diabetes 40: 405-12. Review.Search in Google Scholar

Baynes JW, Thorpe SR. (1999). Role of oxidative stress in diabetic complications: a new perspective on an old paradigm. Diabetes 48: 1-9. Review.Search in Google Scholar

Beaulieu LP, Harris CS, Saleem A, Cuerrier A, Haddad PS, Martineau LC, Bennett SA, Arnason JT. (2010). Inhibitory effect of the Cree traditional medicine wiishichimanaanh (Vaccinium vitis-idaea) on advanced glycation end-product formation: identification of active principles. Phytother Res 24: 741-747.Search in Google Scholar

Beyer-Mears A, Farnsworth NP. (1979). Diminished sugar cataractogenesis by quercetin. Exp Eye Res 28: 709-716.Search in Google Scholar

Bhimanagouda S, Patil GK, Jayaprakasha KN, Chidambara Murthy, Amit Vikram. (2009). Bioactive Compounds: Historical Perspectives, Opportunities, and Challenges. J Agric Food Chem 5: 8142-8160.Search in Google Scholar

Bischoff SC. (2008). Quercetin: potentials in the prevention and therapy of disease. Curr Opin Clin Nutr Metab Care 11: 733-740.Search in Google Scholar

Bockelbrink A, Roll S, Ruether K, Rasch A, Greiner W, Willich SN. (2008). Cataract surgery and the development or progression of age-related macular degeneration: a systematic review. Surv Ophthalmol 53: 359-367.Search in Google Scholar

Boots AW, Haenen GRMM, Bast A. (2008). Health effects of quercetin: From antioxidant to nutraceutical. Eur J Pharm 585: 325-337.Search in Google Scholar

Bors W, Heller W, Michel C, Saran M. (1990). Flavonoids as antioxidants. Determination of radical-scavanging efficiences. In Methods in Enzymology (Packer L, Glazer AN, Eds.; Academic Press: San Diego CA) vol. 186, pp. 343-355.Search in Google Scholar

Bors W, Michel C. (2002). Chemistry of the antioxidant. Effect of polyphenols. Ann NY Acad Sci 957: 57-69.Search in Google Scholar

Bravo L. (1998). Polyphenols: chemistry, dietary sources, metabolism, and nutritional significance. Nutr Rev 56: 317-333.Search in Google Scholar

Brian G, Taylor H. (2001). Cataract blindness - challenges for the 21st century. Bulletin of World Health Organization 79: 249-256.Search in Google Scholar

Bron AJ, Brown NA, Harding JJ, Ganea E. (1998). The lens and cataract in diabetes. Int Ophthalmol Clin 38: 37-67.Search in Google Scholar

Bron AJ, Vrensen GF, Koretz J, Maraini G, Harding JJ. (2000). The ageing lens. Ophthalmologica 214: 86-104. Review.Search in Google Scholar

Brownlee M. (2000). Negative consequences of glycation. Metabolism 49(2 Suppl 1): 9-13.Search in Google Scholar

Brownlee M. (2001). Biochemistry and molecular cell biology of diabetic complications. Nature 414: 813-820.Search in Google Scholar

Brownlee M. (2005). The pathobiology of diabetic complications: a unifying mechanism. Diabetes 54: 1615-1625.Search in Google Scholar

Butkovic V, Klasinc L, Bors W. (2004). Kinetic study of flavonoid reactions with stable radicals. J Agric Food Chem 52: 2816-2820.Search in Google Scholar

Cao G, Sofic E, Prior RL. (1997). Antioxidant and prooxidant behavior of flavonoids: structure-activity relationships. Free Rad Biol Med 22: 749-760.Search in Google Scholar

Carbone V, Zhao HT, Chung R, Endo S, Hara A, El-Kabbani O. (2009). Correlation of binding constants and molecular modelling of inhibitors in the active sites of aldose reductase and aldehyde reductase. Bioorg Med Chem 17: 1244-1250.Search in Google Scholar

Cervantes-Laurean D, Schramm DD, Jacobson EL, Halaweish I, Bruckner GG, Boissonneault GA. (2006). Inhibition of advanced glycation end product formation on collagen by rutin and its metabolites. J Nutr Biochem 17: 531-540.Search in Google Scholar

Chethan S, Dharmesh SM, Malleshi NG. (2008). Inhibition of aldose reductase from cataracted eye lenses by finger millet (Eleusine coracana) polyphenols. Bioorg Med Chem 16: 10085-10090.Search in Google Scholar

Clifford MN. (2004). Diet-derived phenols in plasma and tissues andtheir implications for health. Planta Med 70: 1103-14. Review.Search in Google Scholar

Costantino L, Rastelli G, Gamberini MC, Vinson JA, Bose P, Iannone A, Staffieri M, Antolini L, Del Corso A, Mura U, Albasini A. (1999). 1-Benzopyran-4-one antioxidants and aldose reductase inhibitors. J Med Chem 42: 1881-1893.Search in Google Scholar

Costantino L, Rastelli G, Gamberini MC, Barlocco D. (2000). Pharmacological approaches to the treatment of diabetic complications. Expert Opin Ther Patents 10: 1245-1262.Search in Google Scholar

Cornish KM, Williamson G, Sanderson J. (2002). Quercetin metabolism in the lens: role in inhibition of hydrogen peroxide induced cataract. Free Rad Biol Med 33: 63-70.Search in Google Scholar

Coudert P, Albuisson E, Boire JY, Duroux E, Bastide P, Couquelet J. (1994). Synthesis of pyridazine acetic acid derivatives possessing aldose reductase inhibitory activity and antioxidant properties. Eur J Med Chem 29: 471-477.Search in Google Scholar

Crozier A, Del Rio D, Clifford MN. (2010). Bioavailability of dietary flavonoids and phenolic compounds. Mol Aspects Med 31: 446-467.Search in Google Scholar

Crozier A, Jaganath IB, Clifford MN. (2009). Dietary phenolics: chemistry, bioavailability and effects on health. Nat Prod Rep 26: 1001-1043. Review.Search in Google Scholar

Day AJ, Canada FJ, Diaz JC, Kroon PA, McLauchlan R, Faulds CB, Plumb GW, Morgan MR, Williamson G. (2000). Dietary flavonoid and isoflavone glycosides are hydrolysed by the lactase site of lactase phlorizin hydrolase. FEBS Lett 468: 166-170.Search in Google Scholar

Day AJ, Dupont MS, Ridley S, et al. (1998). Deglycosylation of flavonoid and isoflavonoid glycosides by human small intestine and liver beta-glucosidase activity. FEBS Lett 436: 71-75.Search in Google Scholar

Del Corso A, Cappiello M, Mura U. (2008). From a dull enzyme to something else: facts and perspectives regarding aldose reductase. Curr Med Chem 15: 1452-1461.Search in Google Scholar

Demopoulos VJ, Zaher N, Zika C, Anagnostou C, Mamadou E, Alexiou P, Nicolaou I. (2005). Compounds that combine aldose reductase inhibitory activity and ability to prevent the glycation (glucation and/or fructation) of proteins as putative pharmacotherapeutic agents. Drug Design Reviews-Online 2: 293-304.Search in Google Scholar

Durukan AH, Evereklioglu C, Hurmeric V, Kerimoglu H, Erdurman C, Bayraktar MZ, Mumcuoglu T. (2006). Ingestion of IH636 grape seed proanthocyanidin extract to prevent selenite-induced oxidative stress in experimental cataract. J Cataract Refract Surg 32: 1041-1045.Search in Google Scholar

El-Kabbani O, Ruiz F, Darmanin C, Chung RP. (2004). Aldose reductase structures: implications for mechanism and inhibition. Cell Mol Life Sci 61: 750-762.Search in Google Scholar

El-Kabbani O, Podjarny A. (2007). Selectivity determinants of the aldose and aldehyde reductase inhibitor-binding sites. Cell Mol Life Sci 64: 1970-1978. Review.Search in Google Scholar

Ertekin MV, Koçer I, Karslıoglu I, Taysi S, Gepdiremen A, Sezen O, Balcı E, Bakan N. (2004). Effects of oral ginkgo biloba supplementation on cataract formation and oxidative stress occurring in lenses of rats exposed to total cranium radiotherapy. Jpn J Ophthalmol 48: 499-502.Search in Google Scholar

Fossen T, Pedersen AT, Andersen M. (1998). Flavonoids from red onion (Allium cepa). Phytochemistry 47: 281-285.Search in Google Scholar

Gayathri Devi V, Rooban BN, Sasikala V, Sahasranamam V, Abraham A. (2010). Isorhamnetin-3-glucoside alleviates oxidative stress and opacification in selenite cataract in vitro. Toxicol in Vitro 24: 1662-1669.Search in Google Scholar

Gee JM, DuPont SM, Day AJ, Plumb GW, Williamson G, Johnson IT. (2000). Intestinal transport of quercetin glycosides in rats involves both deglycosylation and interaction with the hexose transport pathway. J Nutr 130: 2765-2771.Search in Google Scholar

Giacco F, Brownlee M. (2010). Oxidative stress and diabetic complications. Circ Res 107: 1058-1070.Search in Google Scholar

Grotte D, Mattox V, Brubaker R. (1985). Fluorescent, physiological and pharmacokinetic properties of fluorescein. Exp Eye Res 40: 23-33.Search in Google Scholar

Gupta SK, Halder N, Srivastava S, Trivedi D, Joshi S, Varma SD. (2002). Green tea (Camellia sinensis) protects against selenite-induced oxidative stress in experimental cataractogenesis. Ophthalmic Res 34: 258-263.Search in Google Scholar

Gupta SK, Selvan VK, Agrawal SS, Saxena R. (2009). Advances in pharmacological strategies for the prevention of cataract development. Indian J Ophthalmol 57: 175-183.Search in Google Scholar

Hanasaki Y, Ogawa S, Fukui S. (1994). The correlation between active oxygens scavenging and antioxidative effects of flavonoids. Free Rad Biol Med 16: 845-850.Search in Google Scholar

Harding JJ. (2002). Viewing molecular mechanisms of ageing through a lens. Ageing Res Rev 1: 465-479.Search in Google Scholar

Head KA. (2001). Natural therapies for ocular disorders, part two: cataracts and glaucoma. Altern Med Rev 6: 141-166. Review.Search in Google Scholar

Heim KE, Tagliaferro TR, Bobilya DJ. (2002). Flavonoid antioxidants: chemistry, metabolism and structure-activity relationships. J Nutr Biochem 13: 572-584.Search in Google Scholar

Hightower KR. (1995). The role of the lens epithelium in development of UV cataract. Curr Eye Res 14: 71-78.Search in Google Scholar

Hollman PCH, Bijsman MNCP, van Gameren Y, et al. (1999). The sugar moiety is a major determinant of the absorption of dietary flavonoid glycosides in man. Free Radic Res 31: 569-573.Search in Google Scholar

Huang R, Shi F, Lei T, Song Y, Hughes CL, Liu G. (2007). Effect of the isoflavone genistein against galactose-induced cataracts in rats. Exp Biol Med (Maywood) 232: 118-125.Search in Google Scholar

Ioku K, Pongpiriyadacha Y, Konishi Y, et al. (1998). Betaglucosidase activity in the rat small intestine toward quercetinmonoglucosides. Biosci Biotechnol Biochem 62: 1428-1431.Search in Google Scholar

Isai M, Sakthivel M, Ramesh E, Thomas PA, Geraldine P. (2009). Prevention of selenite-induced cataractogenesis by rutin in Wistar rats. Mol Vis 15: 2570-2577.Search in Google Scholar

Jaganath IB, Mullen W, Edwards CA, Crozier A. (2006). The relative contribution of the small and large intestine to the absorption and metabolism of rutin in man. Free Rad Res 40: 1035-1046.Search in Google Scholar

Javadzadeh A, Ghorbanihaghjo A, Bonyadi S, Rashidi MR, Mesgari M, Rashtchizadeh N, Argani H. (2009). Preventive effect of onion juice on selenite-induced experimental cataract. Indian J Ophthalmol 57: 185-189.Search in Google Scholar

Jia Z, Song Z, Zhao Y, Wang X, Liu P. (2011). Grape seed proanthocyanidin extract protects human lens epithelial cells from oxidative stress via reducing NF-κB and MAPK protein expression. Mol Vis 17: 210-217.Search in Google Scholar

Jung SH, Lee YS, Lee S, Lim SS, Kim YS, Shin KH. (2002). Isoflavonoids from the rhizomes of Belamcanda chinensis and their effects on aldose reductase and sorbitol accumulation in streptozotocin induced diabetic rat tissues. Arch Pharm Res 25: 306-312.Search in Google Scholar

Jung HA, Yoon NY, Kang SS, Kim YS, Choi JS. (2008). Inhibitory activities of prenylated flavonoids from Sophora flavescens against aldose reductase and generation of advanced glycation endproducts. J Pharm Pharmacol 60: 1227-1236.Search in Google Scholar

Jung HA, Jung YJ, Yoon NY, Jeong da M, Bae HJ, Kim DW, Na DH, Choi JS. (2008). Inhibitory effects of Nelumbo nucifera leaves on rat lens aldose reductase, advanced glycation endproducts formation, and oxidative stress. Food Chem Toxicol 46: 3818-3826.Search in Google Scholar

Jung HA, Kim YS, Choi JS. (2009). Quantitative HPLC analysis of two key flavonoids and inhibitory activities against aldose reductase from different parts of the Korean thistle, Cirsium maackii. Food Chem Toxicol 47: 2790-2797.Search in Google Scholar

Jung HA, Islam MD, Kwon YS, Jin SE, Son YK, Park JJ, Sohn HS, Choi JS. (2011). Extraction and identification of three major aldose reductase inhibitors from Artemisia montana. Food Chem Toxicol 49: 376-384.Search in Google Scholar

Kalt W, Hanneken A, Milbury P, Tremblay F. (2010). Recent research on polyphenolics in vision and eye health. J Agric Food Chem 58: 4001-4007.Search in Google Scholar

Kamei A. (1998). Partial properties of four glycosidases in normal human lens and variations in their enzyme activities during aging and with the advance of lens coloration. Biol Pharm Bull 21: 982-986.Search in Google Scholar

Kawanishi K, Ueda H, Moriyasu M. (2003). Aldose reductase inhibitors from the nature. Curr Med Chem 10: 1353.Search in Google Scholar

Kay CD. (2010). The future of flavonoid research. Br J Nutr 104(Suppl 3): S91-S95.Search in Google Scholar

Kilic F, Bhardwaj R, Trevithick JR. (1996). Modelling cortical cataractogenesis. XVIII. In vitro diabetic cataract reduction by venoruton. A flavonoid which prevents lens opacification. Acta Ophthalmol Scand 74: 372-378.Search in Google Scholar

Kroon PA, Clifford MN, Crozier A, Day AJ, Donovan JL, Manach C, Williamson G. (2004). How should we assess the effects of exposure to dietary polyphenols in vitro? Am J Clin Nutr 80: 15-21.10.1093/ajcn/80.1.1515213022Search in Google Scholar

Kyselova Z, Stefek M, Bauer V. (2004). Pharmacological prevention of diabetic cataract. J Diabetes Complications 18: 129-140. Review.Search in Google Scholar

Kyselova Z. (2010). Different experimental approaches in modelling cataractogenesis: An overview of selenite-induced nuclear cataract in rats. Interdisc Toxicol 3: 3-14.Search in Google Scholar

La Motta C, Sartini S, Mugnaini L, Simorini F, Taliani S, Salerno S, Marini AM, Da Settimo F, Lavecchia A, Novellino E, Cantore M, Failli P, Ciuffi M. (2007). Pyrido[1,2-a]pyrimidin-4-one derivatives as a novel class of selective aldose reductase inhibitors exhibiting antioxidant activity. J Med Chem 50: 4917-4927.Search in Google Scholar

Lee SM, Ko IG, Kim SE, Kim DH, Kang BN. (2010). Protective effect of catechin on apoptosis of the lens epithelium in rats with N-methyl-N-nitrosourea-induced cataracts. Korean J Ophthalmol 24: 101-107.Search in Google Scholar

Lee YS, Kim SH, Jung SH, Kim JK, Pan CH, Lim SS. (2010). Aldose reductase inhibitory compounds from Glycyrrhiza uralensis. Biol Pharm Bull 33: 917-921.Search in Google Scholar

Lija Y, Biju PG, Reeni A, Cibin TR, Sahasranamam V, Abraham A. (2006). Modulation of selenite cataract by the flavonoid fraction of emilia sonchifolia in experimental animal models. Phytother Res 20: 1091-1095.Search in Google Scholar

Lim SS, Jung SH, Ji J, Shin KH, Keum SR. (2001). Synthesis of flavonoids and their effects on aldose reductase and sorbitol accumulation in streptozotocin-induced diabetic rat tissues. J Pharm Pharmacol 53: 653-668.Search in Google Scholar

Lu M-P, Wang R, Song X, Chibbar R, Wang X, Wu L, Q Meng QH. (2008). Dietary soy isoflavones increase insulin secretion and prevent the development of diabetic cataracts in streptozotocin-induced diabetic rats. Nutr Res 28: 464-471.Search in Google Scholar

Majumdar S, Srirangam R. (2010). Potential of the bioflavonoids in the prevention/treatment of ocular disorders. J Pharm Pharmacol 62: 951-965.Search in Google Scholar

Manach C, Williamson G, Morand C, Scalbert A, Remesy C. (2005). Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies. Am J Clin Nutr 81: 2230S-2242S.Search in Google Scholar

Matsuda, H, Morikawa T, Toguchida I, Yoshikawa M. (2002). Structural requirements of flavonoids and related compounds for aldose reductase inhibitory activity. Chem Pharm Bull 50: 788-795.Search in Google Scholar

Matsuda H, Wang T, Managi H, Yoshikawa M. (2003). Structural requirements of flavonoids for inhibition of protein glycation and radical scavenging activities. Bioorg Med Chem 11: 5317-5323.Search in Google Scholar

Meyer CH, Sekundo W. (2005). Nutritional supplementation to prevent cataract formation. Dev Ophthalmol 38: 103-119.Search in Google Scholar

Miean KH, Mohamed S. (2001). Flavonoid (myricetin, quercetin, kaempferol, luteolin and apigenin) content of edible tropical plants. J Agr Food Chem 49: 3106-1312.Search in Google Scholar

Miyamoto S. (2002). Recent advances in aldose reductase inhibitors: potential agents for the treatment of diabetic complications. Expert Opin. Ther Patents 12: 621-631.Search in Google Scholar

Mohan M, Gupta SK, Agnihotri S, Joshi S, Uppal RK. (1988). Anticataract action of topical quercetin and myricetin in galactosemic rats. Med Sci Res 6: 685-686.Search in Google Scholar

Monnier VM, Cerami A. (1981). Nonenzymatic browning in vivo: possible process for aging of long-lived proteins. Science 211: 491-493.Search in Google Scholar

Monnier VM, Sell DR, Genuth S. (2005). Glycation products as markers and predictors of the progression of diabetic complications. Ann N Y Acad Sci 1043: 567-581.Search in Google Scholar

Morand C, Crespy V, Manach C, Besson C, Demigne C, Remesy C. (1998). Plasma metabolites of quercetin and their antioxidant properties. Am J Physiol 275: R212-R219.Search in Google Scholar

Morimitsu Y, Yoshida K, Esaki S, Hirota A. (1995). Protein glycation inhibitors from thyme (Thymus vulgaris). Biosci Biotechnol Biochem 59: 2018-2021.Search in Google Scholar

Mullen W, Edwards CA, Crozier A. (2006). Absorption, excretion and metabolic profiling of methyl-, glucuronyl- glucosyl and sulpho-conjugates of quercetin in human plasma and urine after ingestion of onions. Br J Nutr 96: 107-116.Search in Google Scholar

Nagao A, Seki M, Kobayashi H. (1999). Inhibition of xanthine oxidase by flavonoids. Biosci Biotechnol Biochem 63: 1787-1790.Search in Google Scholar

Nagaraj RH, Linetsky M, Stitt AW. (2010). The pathogenic role of Maillard reaction in the aging eye. Amino Acids Oct 21. [Epub ahead of print]Search in Google Scholar

Nagasawa T, Tabata N, Ito Y, Nishizawa N, Aiba Y, Kitts DD. (2003). Inhibition of glycation reaction in tissue protein incubations by water soluble rutin derivative. Mol Cell Biochem 249: 3-10.Search in Google Scholar

Nagasawa T, Tabata N, Ito Y, Aiba Y, Nishizawa N, Kitts DD. (2003). Dietary G-rutin suppresses glycation in tissue proteins of streptozotocin-induced diabetic rats. Mol Cell Biochem 252: 141-147.Search in Google Scholar

Nakai N, Fujii Y, Kobashi K, Nomura K. (1985). Aldose reductase inhibitors: flavonoids, alkaloids, acetophenones, benzophenones, and pirohydantoins of chroman. Arch Biochem Biophys 239: 491-496.Search in Google Scholar

Nakano M, Orimo N, Katagiri N, Tsubata M, Takahashi J, Van Chuyen N. (2008). Inhibitory effect of astraxanthin combined with Flavangenol on oxidative stress biomarkers in streptozotocin-induced diabetic rats. Int J Vitam Nutr Res 78: 175-182.Search in Google Scholar

Nijveldt RJ, van Nood E, van Hoorn DEC, Boelens PG, van Norren K, van Leeuwen PAM. (2001). Flavonoids: a review of probable mechanisms of action and potential applications. Am J Clin Nutr 74: 418.Search in Google Scholar

Obrosova IG, Chung SS, Kador PF. (2010). Diabetic cataracts: mechanisms and management. Diabetes Metab Res Rev 26: 172-180.Search in Google Scholar

Okuda J, Miwa I, Inagaki K, Horie T, Nakayama M. (1982). Inhibition of aldose reductases from rat and bovine lenses by flavonoids. Biochem Pharmacol 31: 3807-3822.Search in Google Scholar

Olson RJ, Mamalis N, Werner L, Apple DJ. (2003). Cataract treatment in the beginning of the 21st century. Am J Ophth 136: 146-154.Search in Google Scholar

Orhan H, Marol S, Hepsen IF, Sahin G. (1999). Effects of some probable antioxidants on selenite-induced cataract formation and oxidative stress-related parameters in rats. Toxicology 139: 219-232.Search in Google Scholar

Pashikanti S, de Alba DR, Boissonneault GA, Cervantes-Laurean D. (2010). Rutin metabolites: novel inhibitors of nonoxidative advanced glycation end products. Free Radic Biol Med 48: 656-663.Search in Google Scholar

Pietta PG. (2000). Flavonoids as antioxidants. J Nat Prod 63: 1035.Search in Google Scholar

Pollreisz A, Schmidt-Erfurth U. (2010). Diabetic cataract - pathogenesis, epidemiology and treatment. J Ophthalmol 2010: 608751.Search in Google Scholar

Ramana BV, Raju TN, Kumar VV, Reddy PUM. (2007). Defensive role of quercetin against imbalances of calcium, sodium, and potassium in galactosemic cataract. Biol Trace Elem Res 119: 35-41.Search in Google Scholar

Rice-Evans, C. (2001). Flavonoid antioxidants. Curr Med Chem 8: 797.Search in Google Scholar

Rooban BN, Lija Y, Biju PG, Sasikala V, Sahasranamam V, Abrahama A. (2009). Vitex negundo attenuates calpain activation and cataractogenesis in selenite models. Exp Eye Res 88: 575-582.Search in Google Scholar

Rooban BN, Sasikala V, Sahasranamam V, Abraham A. (2011). Amelioration of selenite toxicity and cataractogenesis in cultured rat lenses by Vitex negundo. Graefes Arch Clin Exp Ophthalmol Jan 15. [Epub ahead of print]10.1007/s00417-010-1598-021240520Search in Google Scholar

Sanderson J, McLauchlan WR, Williamson G. (1999). Quercetin inhibits hydrogen peroxide-induced oxidation of the rat lens. Free Rad Biol Med 26: 639-645.Search in Google Scholar

Scalbert A, Williamson G. (2000). Dietary intake and bioavailability of polyphenols. J Nutr 130(8S Suppl): 2073S-2085S.Search in Google Scholar

Scalbert A, Morand C, Manach C, Rémésy C. (2002). Absorption and metabolism of polyphenols in the gut and impact on health. Biomed. Pharmacother 56: 276-282.Search in Google Scholar

Shamsi FA, Sharkey E, Creighton D, Nagaraj RH. (2000). Maillard reactions in lens proteins: methylglyoxal-mediated modifications in the rat lens. Exp Eye Res 70: 369-380.Search in Google Scholar

Sharma KK, Santhoshkumar P. (2009). Lens aging: effects of crystallins. Biochim Biophys Acta 1790: 1095-1108. Review.Search in Google Scholar

Shearer TR, Ma H, Fukiage C, Azuma M. (1997). Selenite nuclear cataract: review of the model. Mol Vis 3: 8-17.Search in Google Scholar

Scheller S, Wilczok T, Imielski S, Krol W, Gabrys J, Shani J. (1990). Free radical scavenging by ethanol extract of propolis. Int J Radiat Biol 57: 461-465.Search in Google Scholar

Sperker B, Backman JT, Kroemer HK. (1997). The role of β-glucuronidase in drug disposition and drug targeting in humans. Clin Pharmacokinet 33: 18-31.Search in Google Scholar

Stefek M, Snirc V, Djoubissie PO, Majekova M, Demopoulos V, Rackova L, Bezakova Z, Karasu C, Carbone V, El-Kabbani O. (2008). Carboxymethylated pyridoindole antioxidants as aldose reductase inhibitors: Synthesis, activity, partitioning, and molecular modeling. Bioorg Med Chem 16: 4908-4920.Search in Google Scholar

Stitt AW. (2005). The maillard reaction in eye diseases. Ann N Y Acad Sci 1043: 582-597.Search in Google Scholar

Suryanarayana P, Kumar PA, Saraswat M, Petrash JM, Reddy GB. (2004). Inhibition of aldose reductase by tannoid principles of Emblica officinalis: implications for the prevention of sugar cataract. Mol Vis 10: 148-154.Search in Google Scholar

Suzen S, Buyukbingol E. (2003). Recent studies of aldose reductase enzyme inhibition for diabetic complications. Curr Med Chem 10: 1329-1352.Search in Google Scholar

Taylor A. (1993). Cataract: relationship between nutrition and oxidation. J Am Coll Nutr 12: 138-146.Search in Google Scholar

Taylor HR. (1999). Epidemiology of age-related cataract. Eye 13: 445-448.Search in Google Scholar

Thiagarajan G, Chandani S, Sundari SC, Harinarayana Rao S, Kulkarni VA, Balasubramanian D. (2001). Antioxidant properties of green and black tea, and their potential ability to retard the progression of eye lens cataract. Exp Eye Res 73: 393-401.Search in Google Scholar

Thiagarajan G, Chandani S, Harinarayana Rao S, Samuni AM, Chandrasekaran K, Balasubramanian D. (2002). Molecular and cellular assessment of Ginkgo biloba extract as a possible ophthalmic drug. Exp Eye Res 75: 421-430.Search in Google Scholar

Thornalley PJ. (2005). Dicarbonyl intermediates in the Maillard reaction. Ann NY Acad Sci 1043: 111-117.Search in Google Scholar

Thorpe SR, Baynes JW. (1996). Role of the Maillard reaction in diabetes mellitus and diseases of aging. Drugs Aging 9: 69-77.Search in Google Scholar

Turk Z. (2010). Glycotoxines, carbonyl stress and relevance to diabetes and its complications. Physiol Res 59: 147-156.Search in Google Scholar

Urios P, Grigorova-Borsos AM, Sternberg M. (2007). Flavonoids inhibit the formation of the cross-linking AGE pentosidine in collagen incubated with glucose, according to their structure. Eur J Nutr 46: 139-146.Search in Google Scholar

Varma SD, Kinoshita JH. (1976). Inhibition of lens aldose reductase by flavonoids - their possible role in the prevention of diabetic cataracts. Biochem Pharm 25: 2505-2513.Search in Google Scholar

Varma SD, Mikuni I, Kinoshita JH. (1975). Flavonoids as inhibitors of lens aldose reductase. Science 188: 1215-1216.Search in Google Scholar

Varma SD, Mizuno A, Kinoshita JH. (1977). Diabetic Cataracts and Flavonoids. Science 195: 205-206.Search in Google Scholar

Vibin M, Siva Priya SG, N Rooban B, Sasikala V, Sahasranamam V, Abraham A. (2010). Broccoli regulates protein alterations and cataractogenesis in selenite models. Curr Eye Res 35: 99-107.Search in Google Scholar

Walle T. (2004). Absorption and metabolism of flavonoids. Free Radic Biol Med 36: 829-837. Review.Search in Google Scholar

Weinreb RN, Jeng S, Miller AL. (1991). Lysosomal enzyme activity in human aqueous humor. Clin Chim Acta 199: 1-6.Search in Google Scholar

Williamson G, Manach C. (2005). Bioavailability and bioefficacy of polyphenols in humans. II. Review of 93 intervention studies. Am J Clin Nutr 81(1 Suppl): 243S-255S. Review.Search in Google Scholar

Williams RJ, Spencer JP, Rice-Evans C. (2004). Flavonoids: antioxidants or signalling molecules? Free Radic Biol Med 36: 838-849.10.1016/j.freeradbiomed.2004.01.00115019969Search in Google Scholar

Wirasathien L, Pengsuparp T, Suttisri R, Ueda H, Moriyasu M, Kawanishi K. (2007). Inhibitors of aldose reductase and advanced glycation end-products formation from the leaves of Stelechocarpus cauliflorus R.E. Fr. Phytomedicine 14: 546-550.Search in Google Scholar

Wu CH, Yen GC. (2005). Inhibitory effect of naturally occurring flavonoids on the formation of advanced glycation endproducts. J Agric Food Chem 53: 3167-3173.Search in Google Scholar

Yao K, Zhang L, Zhang Y, Ye P, Zhu N. (2008). The flavonoid fisetin inhibits UV radiation-induced oxidative stress and the activation of NF-kappaB and MAPK signaling in human lens epithelial cells. Mol Vis 14: 1865-1871.Search in Google Scholar

Yabe-Nishimura C. (1998). Aldose reductase in glucose toxicity: a potential target for the prevention of diabetic complications. Pharmacol Rev 50: 21-33.Search in Google Scholar

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