<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml"><p>Nitric oxide (NO) is a small gas molecule derived from at least three isoforms of the enzyme termed nitric oxide synthase (NOS). More than 15 years ago, the question of feedback regulation of NOS activity and expression by its own product was raised. Since then, a number of trials have verified the existence of negative feedback loop both in vitro and in vivo. NO, whether released from exogenous donors or applied in authentic NO solution, is able to inhibit NOS activity and also intervenes in NOS expression processes by its effect on transcriptional nuclear factor NF-κB. The existence of negative feedback regulation of NOS may provide a powerful tool for experimental and clinical use, especially in inflammation, when massive NOS expression may be detrimental.</p></abstract>

Nitric oxide (NO) is a small gas molecule derived from at least three isoforms of the enzyme termed nitric oxide synthase (NOS). More than 15 years ago, the question of feedback regulation of NOS activity and expression by its own product was raised. Since then, a number of trials have verified the existence of negative feedback loop both in vitro and in vivo. NO, whether released from exogenous donors or applied in authentic NO solution, is able to inhibit NOS activity and also intervenes in NOS expression processes by its effect on transcriptional nuclear factor NF-κB. The existence of negative feedback regulation of NOS may provide a powerful tool for experimental and clinical use, especially in inflammation, when massive NOS expression may be detrimental.

Biochemical aspects of nitric oxide synthase feedback regulation by nitric oxide

Department of Physiology, Jessenius Faculty of Medicine, Comenius University, Martin, Slovak Republic

Institute of Normal and Pathological Physiology, Slovak Academy of Sciences, Bratislava, Slovak Republic

Interdisciplinary Toxicology

{"article-title":"Biochemical aspects of nitric oxide synthase feedback regulation by nitric oxide"}

Nitric oxide (NO) is a small gas molecule derived from at least three isoforms of the enzyme termed nitric oxide synthase (NOS). More than 15 years ago, the...

Biochemical aspects of nitric oxide synthase feedback regulation by nitric oxide

Published Online: Jun 17, 2011

Page range: 63 - 68

DOI: https://doi.org/10.2478/v10102-011-0012-z

Keywords
nitric oxide synthase, feedback regulation, inflammation, NF-κB

This content is open access.

Biochemical aspects of nitric oxide synthase feedback regulation by nitric oxide

Published Online: Jun 17, 2011

Page range: 63 - 68

DOI: https://doi.org/10.2478/v10102-011-0012-z

Keywordsnitric oxide synthase, feedback regulation, inflammation, NF-κB

This content is open access.

Keywords
nitric oxide synthase, feedback regulation, inflammation, NF-κB