<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml"><p>Effects of natural and structurally transformed lignans compared with stilbenes or stilbenoids on production of nitric oxide (NO) triggered by lipopolysaccharide (LPS) and interferon-γ (IFN-γ), tested under <italic>in vitro</italic> conditions using murine resident peritoneal macrophages, are reviewed. Relation between the molecular structure and immunobiological activity was investigated, and implication of substituents, double bond stereochemistry, or cyclic attachments (double bond geometry fixation) was assessed. The focus was on lignans and stilbenoids because they were originally selected for a joint project of common interest to phytochemical and pharmacological investigation and because they represent well interesting and universally attractive groups of polyphenols with a feasible potential for therapeutic or nutraceutic utilization.</p></abstract>

Effects of natural and structurally transformed lignans compared with stilbenes or stilbenoids on production of nitric oxide (NO) triggered by lipopolysaccharide (LPS) and interferon-γ (IFN-γ), tested under in vitro conditions using murine resident peritoneal macrophages, are reviewed. Relation between the molecular structure and immunobiological activity was investigated, and implication of substituents, double bond stereochemistry, or cyclic attachments (double bond geometry fixation) was assessed. The focus was on lignans and stilbenoids because they were originally selected for a joint project of common interest to phytochemical and pharmacological investigation and because they represent well interesting and universally attractive groups of polyphenols with a feasible potential for therapeutic or nutraceutic utilization.

Immunobiological properties of selected natural and chemically modified phenylpropanoids

Institute of Organic Chemistry and Biochemistry, Academy of Sciences, v.v.i., Flemingovo nám. 2, CZ-166 10 Prague, Czech Republic

Institute of Experimental Medicine, Academy of Sciences, v.v.i., Vídeňská 1083, CZ-142 20 Prague, Czech Republic

Faculty of Food and Biochemical Technology, Institute of Chemical Technology Prague, Technická 3, CZ-16628 Prague, Czech Republic

Interdisciplinary Toxicology

Effects of natural and structurally transformed lignans compared with stilbenes or stilbenoids on production of nitric oxide (NO) triggered by...

Immunobiological properties of selected natural and chemically modified phenylpropanoids

Published Online: Apr 18, 2011

Page range: 5 - 10

DOI: https://doi.org/10.2478/v10102-011-0002-1

Keywords
polyphenols, lignans, stilbenes, yatein, podophyllotoxin, resveratrol, inhibition of nitric oxide production, cytotoxicity assessment

This content is open access.

Immunobiological properties of selected natural and chemically modified phenylpropanoids

Published Online: Apr 18, 2011

Page range: 5 - 10

DOI: https://doi.org/10.2478/v10102-011-0002-1

Keywordspolyphenols, lignans, stilbenes, yatein, podophyllotoxin, resveratrol, inhibition of nitric oxide production, cytotoxicity assessment

This content is open access.

Keywords
polyphenols, lignans, stilbenes, yatein, podophyllotoxin, resveratrol, inhibition of nitric oxide production, cytotoxicity assessment