[Abe T, Takngi N, Nagano M, Furuza M, Takeo S (2004). Altered Bad localization and interaction between Bad and Bcl-XL in the hippocampus after transient global ischemia. Brain Res 1009: 159-168.]Search in Google Scholar
[Acuna-Castroviejo D, Coto-Montes A, Gaia Monti M, Ortiz GG, Reiter RJ (1997). Melatonin is protective against MPTP-induced striated and hippocampal lesions. Life Sci 60, PL23-PL29.]Search in Google Scholar
[Acuna-Castroviejo D, Escames G, Carozo A, Leon J, Khaldy H, Reiter RJ (2002). Melatonin, mitochondrial homeostasis and mitochondrial-related diseases. Curr Top Med Chem 2: 133-152.]Search in Google Scholar
[Acuna-Castroviejo D, Martin M, Macias M, Escames G, Leon J, Khaldy H, Reiter RJ (2001). Melatonin, mitochondria, and cellular bioenergetics. J Pineal Res 30: 65-74.]Search in Google Scholar
[Acuna-Castroviejo D, Escames G, Lopez LC, Hitos AB, Leon J (2005). Melatonin and nitric oxide: two required antagonists for mitochondrial homeostasis. Endocrine 27: 159-168.]Search in Google Scholar
[Andrabi SA, Sayeed I, Siemen D, Wolf G, Horn TF (2004). Direct inhibition of the mitochondrial permeability transition pore: a possible mechanism responsible for anti-apoptotic effects of melatonin. FASEB J 18: 869-871.]Search in Google Scholar
[Antolin I, Mayo JC, Sainz RM, de Brio ML, Herrera F, Martin V, Rodriguez C (2002). Protective effect of melatonin in a chronic experimental model of Parkinson's disease. Brain Res 943: 163-172.]Search in Google Scholar
[Auluck PK, Chan HY, Trojanowski JQ, Lee VM, Bonini NM (2002). Chaperone suppression of alpha-synuclein toxicity in a Drosophila model in Parkinson's disease. Science 295: 685-688.]Search in Google Scholar
[Barlow-Walden LR, Reiter RJ, Abe M (1995). Melatonin stimulates brain glutathione peroxidase activity. Neurochem Int 26: 497-502.]Search in Google Scholar
[Baydas G, Gursu MF, Yilmaz S (2002). Daily rhythm of glutathione peroxidase activity, lipid peroxidation and glutathione levels in tissues of pinealectomized rats. Neurosci Lett 323: 195-198.]Search in Google Scholar
[Beal MF (1992). Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses? Ann Neurol 31: 119-130.10.1002/ana.410310202]Search in Google Scholar
[Benitez-King G (2006). Melatonin as a cytoskeletal modulator: implications for cell physiology and disease. J Pineal Res 40: 1-9.]Search in Google Scholar
[Blask DE, Dauchy RT, Sauer LA (2005). Putting cancer to sleep at night: the neuroendocrine/circadian melatonin signal. Endocrine 27: 179-188.]Search in Google Scholar
[Borlongan CV, Kautonzis TK, Freeman TB, Cahill DW, Sanberg PR (1995). Behavioral pathology induced by repeated systemic injections of 3-nitropropionic acid mimics the motoric symptoms of Huntington's disease. Brain Res 697: 254-257.]Search in Google Scholar
[Brainard GC, Hanifin JP, Rollag MD, Greeson J, Byrne B, Glickman G, Gerner E, Sanford B (2001). Human melatonin regulation in not mediated by the three cone photopic visual system. J Clin Endocrinol Metab 86: 433-436.]Search in Google Scholar
[Brandon M, Baldi P, Wallace DC (2006). Mitochondrial mutations in cancer. Oncogene 25: 4647-4662.]Search in Google Scholar
[Bromme HJ, Morke W, Peschke D, Ebelt H, Peschke E (2000). Scavenging effect of melatonin on hydroxyl radicals generated by alloxan. J Pineal Res 29: 201-208.]Search in Google Scholar
[Brown GC (1992). Control of respiration and ATP synthesis in mammalian mitochondria and cells. Biochem J 284: 1-13.]Search in Google Scholar
[Brown GC, Borutaite V (2004). Inhibition of mitochondrial respiratory complex I by nitric oxide, peroxynitrite and S-nitrosothiols. Biochim Biophys Acta 1658: 44-49.]Search in Google Scholar
[Bubenik GA, Pang SF (1997). Melatonin levels in the gastrointestinal tissues of fish, amphibians and a reptile. Gen Comp Endocrinol 106: 415-419.]Search in Google Scholar
[Cabrera J, Reiter RJ, Tan DX, Qi W, Sainz RM, Mayo JC, Garcia JJ, Kim SJ, El-Sokkary G (2000). Melatonin reduces oxidative neurotoxicity due to quinolinic acid: in vitro and in vivo findings. Neuropharmacology 39: 507-514.]Search in Google Scholar
[Cadenas E, Poderoso JJ, Antunes F, Boveris A, Lizasoain I, Moro MA, Knowles RG, Darley-Usmar V, Moncada S (1996). Nitric oxide and peroxynitrite exert distinct effects on mitochondrial respiration which are differentially blocked by glutathione or glucose. Biochem J 314: 877-880.]Search in Google Scholar
[Carrillo-Vico A, Guerrero JM, Lardone PJ, Reiter RJ (2005). A review of the multiple actions of melatonin on the immune system. Endocrine 27: 189-200.]Search in Google Scholar
[Carrillo-Vico A, Reiter RJ, Lardone PJ, Herrera JL, Fernandez-Montesinos R, Guerrero JM, Pozo D (2006). The modulatory role of melatonin on immune responsiveness. Curr Opin Investig Drugs 7: 423-431.]Search in Google Scholar
[Cavallo A, Dolan LM (1996). 6-Hydroxymelatonin sulfate excretion in human puberty. J Pineal Res 21: 225-260.]Search in Google Scholar
[Chen CJ, Gao YQ, Li XJ, Shen DH, Sun FY (2005). Melatonin protects against MPTP/MPP+-induced mitochondrial DNA oxidative damage in vivo and in vitro. J Pineal Res 39: 34-42.]Search in Google Scholar
[Chen ST, Chuang JI, Hong MH, Li EI (2002). Melatonin attenuates MPP+-induced neurodegeneration and glutathione impairment in the nigro striatal dopaminergic pathway. J Pineal Res 32: 262-269.]Search in Google Scholar
[Coles CJ, Edmondson DE, Singer TP (1979). Inactivation of succinate dehydrogenase by 3-nitropropionic acid. J Biol Chem 254: 5161-5167.]Search in Google Scholar
[Coto-Montes A, Tomas-Zapico C, Escames G, Leon J, Rodriguez-Colunga MJ, Tolivia D, Acuna-Castroviejo D (2003). Specific binding of melatonin to purified cell nuclei from mammary gland of Swiss mice: day-night variations and effect of continuous light. J Pineal Res 34: 297-301.]Search in Google Scholar
[Coulom H, Birman S (2004). Chronic exposure to rotenone models: sporadic Parkinson's disease in Drosophila melanogaster. J Neurosci 24: 10993-10998.]Search in Google Scholar
[de Almeida EA, Martinez GR, Klitzke CK, de Medeiros MH, Di Mascio P (2003). Oxidation of melatonin by singlet molecular oxygen produces N1-acetyl-N2-formyl-5-methoxykynuramine. J Pineal Res 35: 131-137.]Search in Google Scholar
[Di Mauro S, Schon EA (2003). Mitochondrial respiratory-chain diseases. N Eng J Med 348: 2656-2668.]Search in Google Scholar
[Dubocovich ML, Markowska M (2005). Functional MT1 and MT2 melatonin receptors in mammals. Endocrine 27: 101-110.]Search in Google Scholar
[El-Sokkary G, Kamel ES, Reiter RJ (2003). Prophylactic effect of melatonin in reducing lead-induced neurotoxicity in the rat. Cell Molec Biol Lett 8: 461-470.]Search in Google Scholar
[Escames G, Leon J, Lopez LC, Acuna-Castroviejo D (2004). Mechanisms in the NMDA receptor inhibition by melatonin in the rat brain striatum. J Neuroendocrinol 16: 925-929.]Search in Google Scholar
[Escames G, Lopez LC, Tapias V, Utrilla MP, Reiter RJ, Hitos AB, Leon J, Rodriguez MI, Acuna-Castroviejo D (2006). Melatonin counteracts inducible mitochondrial nitric oxide synthase-dependent mitochondrial dysfunction in skeletal muscle of septic mice. J Pineal Res 40: 71-78.]Search in Google Scholar
[Feany MB, Bender WW (2000). A Drosophila model of Parkinson's disease. Nature 404: 394-398.]Search in Google Scholar
[Fernandez-Checa JC, Kaplowski N (2005). Hepatic mitochondrial glutathione: transport and role in disease and toxicity. Toxicol Appl Pharmacol 204: 263-273.]Search in Google Scholar
[Friguls B, Petegnief V, Justica C, Pallas M, Planas AM (2002). Activation of ERK and Akt signaling in focal cerebral ischemia: modulation of TGF-alpha and involvement of NMDA receptor. Neurobiol Aging 11: 443-456.]Search in Google Scholar
[Fukutomi J, Fukado A, Fukado F, Hara M, Terada A, Yoshida M (2006). Scavenging activity of indole compounds against cisplatin-induced reactive oxygen species. Life Sci 80: 254-257.]Search in Google Scholar
[Ghafourifar P, Cadenas E (2005). Mitochondrial nitric oxide synthase. Trends Pharmacol Sci 26: 190-195.]Search in Google Scholar
[Gitto E, Karbownik M, Reiter RJ, Tan DX, Cuzzocrea S, Chiurazzi P, Cardaro S, Corona G, Trimarchi G, Barberi I (2001). Effects of melatonin treatment in septic newborns. Pediat Res 50: 756-760.]Search in Google Scholar
[Goldman BD (1999). The circadian timing system and reproduction in mammals. Steroids 64: 679-685.]Search in Google Scholar
[Guenther AL, Schmidt SI, Laatsch H, Fotso S, Ness H, Ressmeyer AR, Poeggeler B, Hardeland R (2005). Reactions of the melatonin metabolite AMK (N1-acetyl-5-methoxykynuramine) with reactive nitrogen species: formation of novel compounds, 3-acetoamidomethyl-6-methoxycinnolinone and 3-nitro-AMK. J Pineal Res 39: 251-260.]Search in Google Scholar
[Guerrero JM, Reiter RJ (2002). Melatonin-immune system relationships. Curr Top Med Chem 2: 167-179.]Search in Google Scholar
[Hardeland R (2005). Antioxidative protection by melatonin: multiplicity of mechanisms from radical detoxification to radical avoidance. Endocrine 27: 119-130.]Search in Google Scholar
[Hardeland R and Poeggeler B (2003). Non-vertebrate melatonin. J Pineal Res 34: 233-241.]Search in Google Scholar
[Hardeland R, Balzer I, Poeggeler B, Fuhrberg B, Uria H, Behrmann G, Wolf R, Meyer TJ, Reiter RJ (1995). On the primary functions of melatonin in evolution: mediation of photoperiodic signals in a unicell, photoxidation, and scavenging of free radicals. J Pineal Res 18: 104-111.]Search in Google Scholar
[Hardeland R, Coto-Montes A, Poeggeler B (2003a). Circadian rhythms, oxidative stress and antioxidative defense mechanisms. Chronobiol Int 20: 921-962.10.1081/CBI-120025245]Search in Google Scholar
[Hardeland R, Poeggeler B, Niebergall R, Zelosko V (2003b). Oxidation of melatonin by carbonate radicals and chemiluminescence emitted during pyrrole ring cleavage. J Pineal Res 34: 69-74.10.1034/j.1600-079X.2003.02941.x]Search in Google Scholar
[Hattori A, Migitaka H, Iigo M, Itoh M, Yamamoto K, Ohtani-Kaneko R, Hara M, Suzuki T, Reiter RJ (1995). Identification of melatonin in plants and its effects on plasma melatonin levels and binding to melatonin receptors in vertebrates. Biochem Mol Biol Int 35: 627-634.]Search in Google Scholar
[Hirata F, Hayaishi O, Tokuyama T, Seno S (1974). In vitro and in vivo formation of two new metabolites of melatonin. J Biol Chem 249: 1311-1313.]Search in Google Scholar
[Ishido M (2007). Melatonin inhibits maneb-induced aggregation of α-synclein in rat pheochromocytoma cells. J Pineal Res 42: 125-130.]Search in Google Scholar
[Itoh MT, Takahashi N, Abe M, Shimiza K (2007). Expression and cellular localization of melatonin-synthesizing enzymes in the rat lens. J Pineal Res 42: 92-96.]Search in Google Scholar
[Jan JE, Wasdell MB, Freeman RD, Bax M (2007). Evidence supporting the use of melatonin in short gestation infants. J Pineal Res 42: 22-26.]Search in Google Scholar
[Jaworek J, Brzozowski T, Konturek SJ (2005). Melatonin as an organoprotector in the stomach and the pancreas. J Pineal Res 38: 73-83.]Search in Google Scholar
[Jimenez-Jorge GM, Guerrero AJ, Jimenez-Caliam MC, Naranjo PJ, Lardone A, Carrillo-Vico C, Osuna C, Molinero P (2007). Evidence for melatonin synthesis in the rat brain during development. J Pineal Res 42: 240-246.]Search in Google Scholar
[Jin BK, Shin DJ, Jeong MY, Gwag MR, Baik HW, Yoon KS, Cho YH, Joo WS, Kim YS, Baik HH (1998). Melatonin protects nigral dopaminergic neurons from 1-methyl-4-phenyl pyridinum. Neurosci Lett 245: 61-64.]Search in Google Scholar
[Jou MJ, Jou SB, Chen HM, Lin CH, Peng TI (2002). Critical role of mitochondrial reactive oxygen species formation in visible laser irradiation-induced apoptosis in rat brain astrocytes (RBA-1). J Biomed Sci 9: 507-516.]Search in Google Scholar
[Jou MJ, Peng TI, Reiter RJ, Jou SB, Wu HY, Wen ST (2004). Visualization of the antioxidant effects of melatonin at the mitochondrial level during oxidative stress-induced apoptosis of rat brain astrocytes. J Pineal Res 37: 55-70.]Search in Google Scholar
[Jou MJ, Peng TI, Yu PZ, Jou SB, Reiter RJ, Chen JY, Wu HY, Chen CC, Hsu LF (2007). Melatonin protects against common deletion of mitochondrial DNA-augmented oxidative stress and apoptosis. J Pineal Res 43: 389-403.]Search in Google Scholar
[Khaldy H, Escames G, Leon J, Bikjdaouene L, Acuna-Castroviejo D (2003). Synergistic effects of melatonin and deprenyl against MPTP-induced mitochondrial damage and DNA depletion. Neurobiol Aging 24: 491-500.]Search in Google Scholar
[Kilic U, Kilic E, Reiter RJ, Bassetti CL, Herman DM (2005a). Signal transduction pathways involved in melatonin-induced neuroprotection after focal cerebral ischemia in mice. J Pineal Res 38: 67-71.10.1111/j.1600-079X.2004.00178.x]Search in Google Scholar
[Kilic E, Kilic U, Reiter RJ, Bassetti CL, Hermann DM (2005b). Tissue-plasminogen activator-induced brain injury is reversed by melatonin: role of iNOS and Akt. J Pineal Res 39: 151-155.10.1111/j.1600-079X.2005.00228.x]Search in Google Scholar
[Kolar J, Machackova I (2005). Melatonin in higher plants: occurrence and possible functions. J Pineal Res 39: 333-341.]Search in Google Scholar
[Laakso ML, Porkka-Heiskanen T, Alila A, Steinberg D, Johansson G (1990). Correlation between salivary and serum melatonin: dependence on serum melatonin levels. J Pineal Res 9: 39-50.]Search in Google Scholar
[Leon J, Acuna-Castroviejo D, Sainz RM, Mayo JC, Tan DX, Reiter RJ (2004). Melatonin and mitochondrial function. Life Sci 75: 765-790.]Search in Google Scholar
[Leon J, Acuna-Castroviejo D, Escames G, Tan DX, Reiter RJ (2005). Melatonin mitigates mitochondrial malfunction. J Pineal Res 38: 1-9.]Search in Google Scholar
[Leon J, Escames G, Rodriguez MI, Lopez LC, Tapias V, Entrena A, Camacho E, Carrion MD, Gallo MA, Espinosa A, Tan DX, Reiter RJ, Acuna-Castroviejo D (2006). Inhibition of neuronal nitric oxide synthase activity by N1-acetyl-5-methoxykynuramine, a brain metabolite of melatonin. J Neurochem 98: 2023-2033.]Search in Google Scholar
[Leon-Blanco MM, Guerrero JM, Reiter RJ, Calvo JR, Pozo D (2003). Melatonin inhibits telomerase activity in the MCF-7 tumor cell line both in vivo and in vitro. J Pineal Res 35: 204-211.]Search in Google Scholar
[Li XJ, Gu J, Lu SD, Sun FJ (2002). Melatonin attenuates MPTP-induced dopaminergic neuronal injury associated with scavenging hydroxyl radical. J Pineal Res 32: 42-52.]Search in Google Scholar
[Ludolph AC, He F, Spencer PS, Hammerstad J, Sabri M (1991). 3-Nitropropionic acid - exogenous animal neurotoxin and possible human striatal toxin. Can J Neurol Sci 18: 494-498.]Search in Google Scholar
[Ma X, Idle JR, Krausz KW, Tan DX, Ceraulo L, Gonzalez FJ (2006). Urinary metabolites and antioxidant products of exogenous melatonin in the mouse. J Pineal Res 40: 343-349.]Search in Google Scholar
[Maldonado MD, Murrillo-Cabezas F, Terron MP, Flores LJ, Tan DX, Manchester LC, Reiter RJ (2007). The potential of melatonin in reducing morbidity-mortality after craniocerebral trauma. J Pineal Res 42: 1-11.]Search in Google Scholar
[Manda K, Ueno M, Anzai K (2007). AFMK, a melatonin metabolite, attenuates X-ray-induced oxidative damage to DNA, proteins and lipids in mice. J Pineal Res 42: 386-393.]Search in Google Scholar
[Martin M, Macias M, Escames G, Leon J, Acuna-Castroviejo D (2000). Melatonin but not vitamins C and E maintains glutathione homeostasis in tert-butyl hydroperoxide induced mitochondrial oxidative stress. FASEB J 14: 1677-1679.]Search in Google Scholar
[Matsura T, Nishida T, Togawa A, Horie S, Kusumoto C, Chata S, Nakada J, Ishibe Y, Yamada K, Ohta Y (2006). Mechanisms of protection by melatonin against acetaminophen-induced liver injury in mice. J Pineal Res 41: 211-219.]Search in Google Scholar
[Matuszek Z, Reszka K, Chignell CF (1997). Reaction of melatonin and related indoles with hydroxyl radicals: ESR and spin trapping investigations. Free Radic Biol Med 23: 367-372.]Search in Google Scholar
[McIntyre IM, Norman TR, Burrows GD, Armstrong SM (1989). Human melatonin response to light is intensity dependent. J Pineal Res 6: 149-156.]Search in Google Scholar
[Morgan IG, Boelen MK (1996). A retinal dark-light switch: a review of the evidence. Vis Neurosci 13: 399-409.]Search in Google Scholar
[Nam E, Lee SM, Koh SE, Joo WS, Maeng S, Im HI, Kim YS (2005). Melatonin protects against neuronal damage induced by 3-nitropropanic acid in rat striatum. Brain Res 1046: 90-96.]Search in Google Scholar
[Ortiz GG, Crespo-Lopez ME, Moran-Moguel C, Garcia JJ, Reiter RJ, Acuna-Castroviejo D (2001). Protective role of melatonin against MPTP-induced mouse brain cell DNA fragmentation and apoptosis in vivo. Neuroendocrinol Lett 22: 101-108.]Search in Google Scholar
[Pablos MI, Agapito MT, Gutierrez R (1995). Melatonin stimulates the activity of detoxifying enzyme glutathione peroxidase in several tissues of chicks. J Pineal Res 19: 111-115.]Search in Google Scholar
[Pablos MI, Reiter RJ, Ortiz GG (1998). Rhythms of glutathione peroxidase and glutathione reductase in brain of chicks and their inhibition by light. Neurochem Int 32: 69-75.]Search in Google Scholar
[Panda S, Nayak SK, Campo B, Walker JR, Hogenesch JB, Jegla T (2005). Illumination of melanopsin's signaling pathway. Science 307: 600-604.]Search in Google Scholar
[Pappolla MA, Reiter RJ, Bryant-Thomas TK, Poeggeler B (2003). Oxidative mediated neurodegeneration in Alzheimer's disease: melatonin and related antioxidants as neuroprotective agents. Curr Med Chem 3: 233-243.]Search in Google Scholar
[Peyrot F, Martin MT, Miguel J, Ducrocq C (2002). Reactivity of peroxynitrite with melatonin as a function of pH and CO2 content. Curr J Org Chem 321: 1-10.]Search in Google Scholar
[Pozo D, Reiter RJ, Calvo JR, Guerrero JM (1997). Inhibition of cerebellar nitric oxide synthase and cyclic GMP production by melatonin via complex formation with calmodulin. J Cell Biochem 65: 430-442.]Search in Google Scholar
[Pozo D, Garcia-Maurino S, Guerrero JM, Calvo RJ (2003). mRNA expression of nuclear receptor RZR/RORα, melatonin membrane receptor MT1, and hydroxyindole-O-methyltransferase in different populations of immune cells. J Pineal Res 37: 48-54.]Search in Google Scholar
[Qi W, Reiter RJ, Tan DX, Garcia JJ, Manchester LC, Karbownik M, Calvo JR (2000). Chromium (III)-induced 8-hydroxydeoxyguanosine in DNA and its reduction by antioxidants: comparative effects of melatonin, ascorbate and vitamin E. Environ Health Persp 108: 2399-2402.]Search in Google Scholar
[Qi W, Reiter RJ, Tan DX, Manchester LL, Siu AW, Garcia JJ (2002). Increased levels of oxidatively damaged DNA induced by chromium (III) and H2O2: protection by melatonin and related molecules. J Pineal Res 29: 54-61.]Search in Google Scholar
[Quay WB (1974). Pineal Chemistry in Cellular and Physiological Mechanisms. Springfield: Charles C. Thomas.]Search in Google Scholar
[Reiter RJ (1980). The pineal and its hormones in the control of reproduction in mammals. Endocr Rev 1: 109-131.]Search in Google Scholar
[Reiter RJ (1987). The melatonin message: duration versus coincidence hypotheses. Life Sci 40: 2119-2131.]Search in Google Scholar
[Reiter RJ (1991a). Melatonin: cell biology of its synthesis and of its physiological interactions. Endocr Rev 12: 151-180.10.1210/edrv-12-2-151]Search in Google Scholar
[Reiter RJ (1991b). Melatonin: the chemical expression of darkness. Mol Cell Endocrinol 79: C153-C158.10.1016/0303-7207(91)90087-9]Search in Google Scholar
[Reiter RJ (1995). Oxidative processes and antioxidative defense mechanisms in the aging brain. FASEB J 9: 526-533.]Search in Google Scholar
[Reiter RJ, Richardson BA, Johnson LY, Ferguson BN, Dinh DT (1980). Pineal melatonin rhythm: reduction in aging Syrian hamsters. Science 210: 1372-1373.]Search in Google Scholar
[Reiter RJ, Craft CM, Johnson JE, King Jr. TS, Richardson BA, Vaughan GM, Vaughan MK (1981). Age-associated reduction in nocturnal pineal melatonin levels in female rats. Endocrinology 109: 1295-1297.]Search in Google Scholar
[Reiter RJ, Tan DX, Osuna C, Gitto E (2000). Actions of melatonin in the reduction of oxidative stress: a review. J Biomed Sci 7: 444-458.]Search in Google Scholar
[Reiter RJ, Tan DX, Leon J, Kilic U, Kilic E (2005). When melatonin gets on your nerves: its beneficial effects in experimental models of stroke. Exp Biol Med 230: 104-17.]Search in Google Scholar
[Reiter RJ, Tan DX, Manchester LC, Simopoulos AP, Maldonado MD, Flores LJ, Terron MP (2007). Melatonin in edible plants (phytomelatonin): identification, concentrations, bioavailability and proposed functions. World Rev Nutr Diet 97: 211-230.]Search in Google Scholar
[Rodriguez C, Mayo JC, Sainz RM, Antolin I, Herrera F, Martin V, Reiter RJ (2004). Regulation of antioxidant enzymes: a significant role for melatonin. J Pineal Res 36: 1-9.]Search in Google Scholar
[Rosen J, Than NN, Koch D, Poeggeler B, Laatsch H, Hardeland R (2006). Interactions of melatonin and its metabolites with the ABTS cation radical: extension of the radical scavenger cascade and formation of a novel class of oxidation products, C2-substitued 3-indolinones. J Pineal Res 41: 374-381.]Search in Google Scholar
[Sack RL, Lewy AJ, Erb DL, Vollmer WM, Singer CM (1986). Human melatonin production decreases with age. J Pineal Res 3: 379-388.]Search in Google Scholar
[Sanchez-Barcello EJ, Cos S, Mediavilla D, Martinez-Compa C, Gonzalez A, Alonso-Gonzalez C (2005). Melatonin-estrogen interactions in breast cancer. J Pineal Res 38: 217-222.]Search in Google Scholar
[Saravanan KS, Sindhu KM, Mohanakumar KP (2005). Acute intranigral infusion of rotenone in rats causes progressive biochemical lesions in the striatum similar to Parkinson's disease. Brain Res 1049: 157-155.]Search in Google Scholar
[Saravanan KS, Sindhu KM, Mohanakumar KP (2007). Melatonin protects against rotenone-induced oxidative stress in a hemiparkinsonian rat model. J Pineal Res 42: 247-253.]Search in Google Scholar
[Saravanan KS, Sindhu KM, Senthikumar KS, Mohanakumar KP (2006). L-Dephenyl protects against rotenone-induced, oxidative stress-mediated dopaminergic neurodegeneration in rats. Neurochem Int 49: 28-40.]Search in Google Scholar
[Sawicka A, Reiter RJ, Tan DX, Wojtasievoicz K, Leneniewska A, Mavrin JK, Balachut D, Czarnocki Z (2004). The synthesis and the structure elucidation of N, O-diacetyl erivative of cyclic 3-hydroxymelatonin. Central Eur J Chem 2: 425-433.]Search in Google Scholar
[Scheffler IE (1999). Mitochondria. New York: Wiley-Liss.10.1002/0471223891]Search in Google Scholar
[Sever G, Atasoy BM, Ersoy Y, Arbak S, Sengoz M, Yegen BC (2004). Melatonin protects against ionizing radiation-induced oxidative damage to corpus cavernosum and urinary bladder in rats. J Pineal Res 37: 241-246.]Search in Google Scholar
[Silva SO, Rodriguez MR, Carvalho SR, Catalani LA, Campa A, Ximenes VF (2004). Oxidation of melatonin and its catabolites, N1-acetyl-N2-formyl-5-methoxykynuramine and N1-acetyl-5-methoxykynuramine, by activated leukocytes. J Pineal Res 37: 171-175.]Search in Google Scholar
[Siu AW, Maldonado MD, Sanchez-Hidalgo M, Tan DX, Reiter RJ (2006). Protective effects of melatonin in experimental free radical-related ocular diseases. J Pineal Res 40: 101-109.]Search in Google Scholar
[Skinner DC, Malpaux B (1999). High melatonin concentrations in third ventricular cerebrospinal fluid are not due to Galen vein blood recirculating through the choroid plexus. Endocrinology 140: 4399-4405.]Search in Google Scholar
[Slominski A, Wortsman J, Tobin DJ (2005). The cutaneous serotoninergic/melatoninergic system: securing a place under the sun. FASEB J 19: 176-194.]Search in Google Scholar
[Sofic E, Rimpapa Z, Jundorovic Z, Sapcanin A, Tahiorovic I, Rustembegovic A, Cao G (2005). Antioxidant capacity of neurohormone melatonin. J Neural Transm 112: 349-358.]Search in Google Scholar
[Sousa SC, Castillo RF (2005). Protective effect of melatonin on rotenone plus Ca2+-induced mitochondrial oxidative stress and PC12 cell death. Antioxid Redox Signal 9: 1110-1116.]Search in Google Scholar
[Stasica P, Ulanski P, Rosiak JM (1998). Melatonin as a hydroxyl radical scavenger. J Pineal Res 25: 65-66.]Search in Google Scholar
[Stefulj J, Hortner M, Shosh M, Schavenstein K, Rinner I, Wolfler A, Semmler J, Liebmann PM (2001). Gene expression of key enzymes of melatonin synthesis of extrapineal tissues of the rat. J Pineal Res 30: 243-247.]Search in Google Scholar
[Tan DX, Chen LD, Poeggeler B, Manchester LC, Reiter RJ (1993). Melatonin: a potent, endogenous hydroxyl radical scavenger. Endocr J 1: 57-60.]Search in Google Scholar
[Tan DX, Manchester LC, Reiter JR, Plummer BF, Hardes LJ, Weintraub ST, Vijayalaxmi, Shepherd AM (1998). A novel melatonin metabolite, cyclic 3-hydroxymelatonin, a biomarker of in vivo hydroxyl radical generation. Biochem Biophys Res Commun 30: 614-620.]Search in Google Scholar
[Tan DX, Manchester CC, Reiter RJ, Qi WB, Zhang M, Weintraub ST, Cabrera J, Sainz RM, Mayo JC (1999a). Identification of highly elevated levels of melatonin in bone marrow: its origin and significance. Biochim Biophys Acta 1472: 206-214.10.1016/S0304-4165(99)00125-7]Search in Google Scholar
[Tan DX, Manchester LC, Reiter RJ, Plummer BF (1999b). Cyclic 3-hydroxymelatonin: a melatonin metabolite generated as a result of hydroxyl radical scavenging. Biol Signals Recept 8: 70-74.10.1159/00001457110085465]Search in Google Scholar
[Tan DX, Manchester LC, Reiter RJ, Plummer BF, Limson J, Weintraub ST, Qi W (2000). Melatonin directly scavenges hydrogen peroxide: a potentially new metabolic pathway of melatonin biotransformation. Free Radic Biol Med 29: 1177-1185.]Search in Google Scholar
[Tan DX, Reiter RJ, Manchester LC, Yan MT, El-Sawi M, Sainz RM, Mayo JC, Kohen R, Allegra M, Hardeland R (2002). Chemical and physical properties and potential mechanisms: melatonin as a broad spectrum antioxidant and free radical scavenger. Curr Top Med Chem 2: 181-182.]Search in Google Scholar
[Tan DX, Manchester LC, Hardeland R, Lopez-Burillo S, Mayo JC, Sainz RM, Reiter RJ (2003). Melatonin: a hormone, a tissue factor, an autocoid, a paracoid, and an antioxidant vitamin. J Pineal Res 34: 75-78.]Search in Google Scholar
[Tan DX, Manchester LC, Di Mascio P, Martinez CR, Prado FM, Reiter RJ (2007a). Novel rhythms of N1-acetyl-N2-formyl-5-methoxykynuramine and its precursor melatonin in water hyacinth: importance for phytoremediation. FASEB J 21: 1724-1729.10.1096/fj.06-7745com17314136]Search in Google Scholar
[Tan DX, Manchester LC, Terron MP, Flores LJ, Reiter RJ (2007b). One molecule, many derivatives: a never-ending interaction of melatonin with reactive oxygen and reactive-nitrogen species? J Pineal Res 42: 28-42.10.1111/j.1600-079X.2006.00407.x17198536]Search in Google Scholar
[Tatoyan A, Giulivi C (1998). Purification and characterization of nitric oxide synthase from rat liver mitochondria. J Biol Chem 273: 11044-11048.]Search in Google Scholar
[Than NN, Heer C, Laatsch H, Hardeland R (2006). Reaction of the melatonin metabolite N1-acetyl-5-methoxykynuramine (AMK) with the ABTS cation radical: identification of new oxidation products. Redox Rep 11: 15-24.]Search in Google Scholar
[Thomas B, Mohanokumar KP (2004). Melatonin protects against oxidative stress caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mouse nigrostriatum. J Pineal Res 36: 25-32.]Search in Google Scholar
[Tomas-Zapico C, Coto-Montes A (2005). A proposed mechanism to explain the stimulatory effect of melatonin on antioxidative enzymes. J Pineal Res 39: 99-104.]Search in Google Scholar
[Tosini G (2000). Melatonin circadian rhythm in the retina of mammals. Chronobiol Int 17: 599-612.]Search in Google Scholar
[Tosini G, Chaurasia SS, Iuvone PM (2006). Regulation of arylakylamine N-acetyltransferase (AANAT) in the retina. Chronobiol Int 23: 381-391.]Search in Google Scholar
[Tunez I, Montilla P, del Carmen Munoz M, Feijoo M, Salcedo M (2004). Protective effect of melatonin on 3-nitropropionic acid-induced oxidative stress in synaptosomes in an animal model in Huntington's disease. J Pineal Res 37: 252-256.]Search in Google Scholar
[Urata Y, Honma S, Goto S, Todoroki S, Iida T, Cho S, Honma K, Kondo T (1999). Melatonin induces gamma-glutamylcysteine synthase mediated by activator protein-1 in human vascular endothelial cells. Free Radic Biol Med 27: 838-847.]Search in Google Scholar
[Valko M, Morris H, Cronin MT (2005). Metals, toxicity and oxidative stress. Curr Med Chem 12: 1161-1208.]Search in Google Scholar
[Vijayalaxmi, Meltz ML, Reiter RJ, Herman TS (1999). Melatonin and protection from damage in blood and bone marrow: whole body radiation studies in mice. J Pineal Res 27: 221-225.]Search in Google Scholar
[Vijayalaxmi, Reiter RJ, Tan DX, Herman TS, Thomas CR Jr (2004). Melatonin as a radioprotective agent: a review. J Radiat Oncol Biol Physics 59: 639-653.]Search in Google Scholar
[Winiarska K, Fraczyk T, Melinska D, Drozak J, Bryla J (2006). Melatonin attenuates diabetes-induced oxidative stress in rabbits. J Pineal Res 40: 168-176.]Search in Google Scholar
[Witt-Enderby PA, Radio NM, Doctor JS, David VL (2006). Therapeutic treatments potentially mediated by melatonin receptors: potential clinical uses in the prevention of osteoporosis, cancer and as an adjuvant therapy. J Pineal Res 41: 297-305.]Search in Google Scholar
[Xu J, Sun S, Wei W, Fu J, Qi W, Manchester LC, Tan DX, Reiter RJ (2007). Melatonin reduces mortality and oxidatively mediated hepatic and renal damage due to diquat treatment. J Pineal Res 42: 166-171.]Search in Google Scholar
[Yamamoto H, Mohanan PV (2002). Melatonin attenuates brain mitochondria DNA damage induced by potassium cyanide in vivo and in vitro. Toxicology 179: 29-36.]Search in Google Scholar
[Yamamoto H, Tang HW (1996). Preventive effect of melatonin against cyanide-induced seizures and lipid peroxidation in mice. Neurosci Lett 207: 89-92.]Search in Google Scholar
[Yamamoto H, Tang H (1998). Effects of 2-amino-7-phosphonohepatanoic acid, melatonin or NG-nitro-L-arginine on cyanide or N-methyl-D-aspartate induced neurotoxicity in rat cortical cells. Toxicol Lett 94: 13-18.]Search in Google Scholar
[Yoshimoto T, Uchino H, He QP, Li PA, Siesjo BK (2001). Cyclosporin A, but not FK506, prevents the downregulation of phosphorylated Akt after transient focal cerebral ischemia in the rat. Brain Res 899: 148-158.]Search in Google Scholar
[You JH, Carter LB, Reiter RJ, Jevtovic-Todorovic V (2006). Melatonin reduces the severity of anesthesia-induced apoptotic neurodegeneration in the developing rat brain. Neurobiol Dis 21: 522-530.]Search in Google Scholar
[Zhang H, Squadrito GL, Uppa R, Pryor WA (1999). Reaction of peroxynitrite with melatonin: a mechanistic study. Chem Res Toxicol 12: 526-534.]Search in Google Scholar
[Zhou G, Kawata T, Furusawa Y, Aoki M, Hirayama R, Ando K, Ito H (2006). Protective effects of melatonin against low and high-LET irradiation. J Radiat Res 47: 175-181.]Search in Google Scholar
[Zisapel N (2007). Sleep and sleep disturbances: biological basis and clinical implications. Cell Mol Life Sci 64: 1174-1186.]Search in Google Scholar
