Open Access

Effect of cytisine on some brain and hepatic biochemical parameters in spontaneously hypertensive rats


Cite

Amacher DE and Schomaker SJ. (1998) Ethylmorphine N-demethylase activity as a marker for cytochrome P 450 CYP 3A activity in rat hepatic microsomes. Toxicol Lett 94: 115-125.10.1016/S0378-4274(97)00108-2Search in Google Scholar

Angelova O. (1971) Certain blood enzyme indices in the chronic treatment of test-animals with cytisine (the preparation Tabex) (in Bulgarian). Chimpharm 2: 13-15.Search in Google Scholar

Basu AK, Ghosh S, Mohanty P and Watlington C. (1994) Augmented arterial pressure responese to cyclosporine in spontaneously hypertensive rats. Role of cytochrome P 450 3A. Hypertension 24: 480-485.Search in Google Scholar

Bump EA, Yvonne C,. Taylor and Brown JM. (1983) Role of glutathione in the hypoxic cell cytotoxicity of misonidazole. Cancer Res 43: 997-1002.Search in Google Scholar

Cediel E, Sanz-Rosa D, Oubina MP, de las Heras N,. Gonzales Fr, Vegazo O, Jimenez J, Cachfeiro V and Lahera V. (2003) Effect of AT1 receptor blockade on hepatic redox status in SHR: possible relevance for endothelial function? AJP-Regul Integr Comp Physiol 285: 674-681.10.1152/ajpregu.00643.2002Search in Google Scholar

Cohen LH, van Leeuwen REW, van Thiel GCF, van Pelt JF and Yap SH. (2000) Equally potent inhibitors of cholesterol synthesis in human hepatocytes have distinguishable effects on different cytochrome P 450 enzymes. Biopharm Drug Dispos 21: 353-364.10.1002/bdd.249Search in Google Scholar

Council of Europe (1991) European Convention for the Protection of Vertebrate Animals used for Experimental and other Scientific Purposes. CETS No. 123.Search in Google Scholar

Deby C and Goutier R. (1990) New perspectives on the biochemistry of superoxide anion and the efficiency of SOD. Biochem Pharmacol 39: 399-405.10.1016/0006-2952(90)90043-KSearch in Google Scholar

Etter JF, Lukas RJ, Benowitz NL, West R and Dresler CM. (2008) Cytisine for smoking cessation: a research agenda. Drug Alcohol Depend 92: 3-8.10.1016/j.drugalcdep.2007.06.017Search in Google Scholar

Fau D, Eugene A, Berson P, Letteron B, Fromenty C and Pessayre D. (1994) Toxicity of the antiandrogen Flutamide in isolated rat hepatocytes. J Pharm Exp Ther, 269: 1-9.Search in Google Scholar

Guengerich FP. (1987) Microsomal enzymes involved in toxicology. Analysis and separation. In Principals and Methods of Toxicology. (Heis AW ed), pp.609-634, New York Raven Press.Search in Google Scholar

Kishi T, Hirooka Y, Kimura Y, Ito K, Shimokava H and Takeshita A. (2004) Increased reactive oxygen species in rostral ventrolateral medulla contribute to neural mechanisms of hypertension in stroke-prone spontaneously hypertensive rats. Circulation 109: 2357-2362.10.1161/01.CIR.0000128695.49900.12Search in Google Scholar

Lippoldt A, Kneisel U, Liebner S, Kalbacher H, Kirsch T, Wolburg H and Haller H. (2000) Structural alterations of tight junctions are associated with loss of polarity in stroke-prone spontaneously hypertensive rat blood-brain barrier endothelial cells. Brain Res 885: 251-261.10.1016/S0006-8993(00)02954-1Search in Google Scholar

Lowry OH. (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193: 265-75.Search in Google Scholar

Lukas RJ. (2006) Pharmacological effects of nicotine and nicotinic receptor subtype pharmacological profiles. in Medication Treatments for Nicotine Dependence (George TP ed), pp. 3-23, CRC Press, Boca Raton.10.1201/9781420005431.ch1Search in Google Scholar

Merrick BA, Davies MH, Cook DE, Holcslaw TL and Schnell RC. (1985) Alterations in hepatic microsomal drug metabolism and cytochrome P-450 proteins in spontaneously hypertensive rats. Pharmacology 30: 129-135.10.1159/0001380613975262Search in Google Scholar

Monostory K, Hazai E and Vereczkey L. (2004) Inhibition of cytochrome P 450 enzymes participating in p-nitrophenol hydroxilation by drugs known as CYP 2E1 inhibitors. Chemico-Biological Interactions 147: 331-340.10.1016/j.cbi.2004.03.00315135088Search in Google Scholar

Omura T and Sato R. (1964) The carbon-monooxide-binding pigment of liver microsomes. J Biol Chem 239: 2370-2385.10.1016/S0021-9258(20)82244-3Search in Google Scholar

Reavill C, Walther B, Stolerman IP and Testa B. (1990) Behavioral and pharmacokinetic studies on nicotine, cytisine and lobeline. Neuropharmacology 29: 619-624.10.1016/0028-3908(90)90022-JSearch in Google Scholar

Tabex. Product monograph, Sopharma, 2006.Search in Google Scholar

Tzankova V and Danchev N. (2007) Cytisine - from ethomedical use to the development as a natural alternative for smoking cessation. Biotechnol & Biotechnol EQ 21: 151-160.10.1080/13102818.2007.10817436Search in Google Scholar

Yoshimoto K, Komura S, Hattori H, Yamori Y, Miura A, Yoshida T, Hioki C, Kato B, Fukuda F, Tanaka S, Hirai A, Nishimura A, Sawai Y and Yashuhara M. (2003) Pharmacological studies of alcohol susceptability and brain monoamine function in stroke-prone spontaneously hypertensive rats (SHRSP) and stroke-resistant spontaneously hypertensive rats (SHRSR). Tohoku J Exp Med 201: 11-22.10.1620/tjem.201.1114609256Search in Google Scholar

eISSN:
1337-9569
ISSN:
1337-6853
Language:
English
Publication timeframe:
4 times per year
Journal Subjects:
Medicine, Clinical Medicine, Pharmacology, Toxicology