<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml"><p>Proton Transfer Reaction Mass Spectrometry (PTR-MS) is a chemical ionization mass spectrometric technique which allows to measure trace gases as, for example, in exhaled human breath. The quantification of compounds at low concentrations is desirable for medical diagnostics. Typically, an increase of measuring accuracy can be achieved if the duration of the measuring process is extended. For real time measurements the time windows for measurement are relatively short, in order to get a good time resolution (e.g. with breath-to-breath resolution during exercise on a stationary bicycle). Determination of statistical detection limits is typically based on calibration measurements, but this approach is limited, especially for very low concentrations. To overcome this problem, a calculation of limit of quantification (LOQ) and limit of detection (LOD), respectively, based on a theoretical model of the measurement process is outlined.</p></abstract>

Proton Transfer Reaction Mass Spectrometry (PTR-MS) is a chemical ionization mass spectrometric technique which allows to measure trace gases as, for example, in exhaled human breath. The quantification of compounds at low concentrations is desirable for medical diagnostics. Typically, an increase of measuring accuracy can be achieved if the duration of the measuring process is extended. For real time measurements the time windows for measurement are relatively short, in order to get a good time resolution (e.g. with breath-to-breath resolution during exercise on a stationary bicycle). Determination of statistical detection limits is typically based on calibration measurements, but this approach is limited, especially for very low concentrations. To overcome this problem, a calculation of limit of quantification (LOQ) and limit of detection (LOD), respectively, based on a theoretical model of the measurement process is outlined.

Model Based Determination of Detection Limits for Proton Transfer Reaction Mass Spectrometer

Breath Research Institute, Austrian Academy of Sciences, Dornbirn, Austria

University Clinic for Anesthesia, Innsbruck Medical University, Innsbruck, Austria

Matej Bel University, Banská Bystrica, Slovakia

Mathematical Institute, Slovak Academy of Sciences, Bratislava, Slovakia

Institute of Measurement Science, Slovak Academy of Sciences, Bratislava, Slovakia

Measurement Science Review

Proton Transfer Reaction Mass Spectrometry (PTR-MS) is a chemical ionization mass spectrometric technique which allows to measure trace gases as, for example,...

Model Based Determination of Detection Limits for Proton Transfer Reaction Mass Spectrometer

Published Online: Jan 20, 2011

Page range: 180 - 188

DOI: https://doi.org/10.2478/v10048-010-0031-5

Keywords
Detection limits, limit of quantification, limit of detection, mass spectrometry, PTR-MS

This content is open access.

Model Based Determination of Detection Limits for Proton Transfer Reaction Mass Spectrometer

Published Online: Jan 20, 2011

Page range: 180 - 188

DOI: https://doi.org/10.2478/v10048-010-0031-5

KeywordsDetection limits, limit of quantification, limit of detection, mass spectrometry, PTR-MS

This content is open access.

Keywords
Detection limits, limit of quantification, limit of detection, mass spectrometry, PTR-MS