<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml"><p>Acute myeloid leukemia (AML) in adults is known to be a heterogeneous disease with diverse chromosomal abnormalities. Some of these abnormalities are found with a high incidence in specific ethnic groups and in certain geographical areas. We report the results of cytogenetic studies of 35 adult Jordanian Arab patients with <italic>de novo</italic> AML diagnosed according to the French-American-British (FAB) criteria. Four patients did not have metaphases secondary to hypocellular bone marrow. The most common morphological subtype was M5 (55%) followed by M3 (19%). Cytogenetic abnormalities were present in 20 patients (65%); t(15;17) translocation in six patients (19%), inv(16) in four patients (13%), t(11;17) in two patients (4%), and the t(8;21) translocation was not present in any patient. Trisomy 8 was the most common numerical chromosomal abnormality [four patients (13%)].</p><p>There were variations and similarities with similar ethninc Arab populations. The most common chromosomal abnormalities were t(15;17), +8 and inv(16). Further and larger crossborder studies are needed.</p></abstract>

Acute myeloid leukemia (AML) in adults is known to be a heterogeneous disease with diverse chromosomal abnormalities. Some of these abnormalities are found with a high incidence in specific ethnic groups and in certain geographical areas. We report the results of cytogenetic studies of 35 adult Jordanian Arab patients with de novo AML diagnosed according to the French-American-British (FAB) criteria. Four patients did not have metaphases secondary to hypocellular bone marrow. The most common morphological subtype was M5 (55%) followed by M3 (19%). Cytogenetic abnormalities were present in 20 patients (65%); t(15;17) translocation in six patients (19%), inv(16) in four patients (13%), t(11;17) in two patients (4%), and the t(8;21) translocation was not present in any patient. Trisomy 8 was the most common numerical chromosomal abnormality [four patients (13%)].There were variations and similarities with similar ethninc Arab populations. The most common chromosomal abnormalities were t(15;17), +8 and inv(16). Further and larger crossborder studies are needed.

Cytogenetic and Morphological Analysis of De Novo Acute Myeloid Leukemia in Adults: A Single Center Study in Jordan

Department of Internal Medicine, King Abdullah University Hospital, Faculty of Medicine, Jordan University of Science and Technology, The Hashemite Kingdom of Jordan

Department of Pathology, King Abdullah University Hospital, Irbid, The Hashemite Kingdom of Jordan

Department of Biotechnology, King Abdullah University Hospital, Irbid, The Hashemite Kingdom of Jordan

Balkan Journal of Medical Genetics

Acute myeloid leukemia (AML) in adults is known to be a heterogeneous disease with diverse chromosomal abnormalities. Some of these abnormalities are found...

Cytogenetic and Morphological Analysis of De Novo Acute Myeloid Leukemia in Adults: A Single Center Study in Jordan

Published Online: Jul 20, 2012

Page range: 5 - 10

DOI: https://doi.org/10.2478/v10034-012-0001-3

Keywords
Acute myeloid leukemia (AML), Cytogenetics, Translocation, Arabs, Jordan

This content is open access.

Cytogenetic and Morphological Analysis of De Novo Acute Myeloid Leukemia in Adults: A Single Center Study in Jordan

Published Online: Jul 20, 2012

Page range: 5 - 10

DOI: https://doi.org/10.2478/v10034-012-0001-3

KeywordsAcute myeloid leukemia (AML), Cytogenetics, Translocation, Arabs, Jordan

This content is open access.

Keywords
Acute myeloid leukemia (AML), Cytogenetics, Translocation, Arabs, Jordan