Cag Repeat Number in Androgen Receptor Gene and Male Infertility

De Kretser DM, Baker HWG. Infertility in men: recent advances and continuing controversies. J Clin Endocrinol Metab 1999; 84(10): 3443-3450.Search in Google Scholar

LaSpada AR, Wilson EM, Lubahn DB, Harding AE, Fishbeck KH. Androgen receptor gene mutations in X-linked spinal and bulbar muscular atrophy. Nature 1991, 352(6330): 77-79.10.1038/352077a0Search in Google Scholar

Chamberlain NL, Driver ED, Miesfeld RL. The length and location of CAG trinucleotide repeats in the androgen receptor N-terminal domain affect transactivation function. Nucleic Acids Res 1994; 22(15): 3181-3186.10.1093/nar/22.15.3181Search in Google Scholar

Giovannucci E, Stampfer MJ, Krithivas K, Brown M, Dahl D, Brufsky A, Talcott J, Hennekens CH, Kantoff PW. The CAG repeat within the androgen receptor gene and its relationship to prostate cancer. Proc Natl Acad Sci USA 1997; 94(7): 3320-3323.10.1073/pnas.94.7.3320Search in Google Scholar

Mifsud A, Ramirez S, Yong EL. Androgen receptor gene CAG trinucleotide repeats in anovulatory infertility and polycystic ovaries. J Clin Endocrinol Metab 2000;85: 3484-3488.10.1210/jcem.85.9.6832Search in Google Scholar

Lim HN, Chen H, McBride S, Dunning AM, Nixon RM, Hughes IA, Hawkins JR. Longer polyglutamine tracts in the androgen receptor are associated with moderate to severe undermasculinized genitalia in XY males. Hum Mol Genet 2000; 9(5): 829-834.10.1093/hmg/9.5.829Search in Google Scholar

Haiman CA, Brown M, Hankinson SE, Spiegelman D, Colditz GA, Willett WC, Kantoff PW, Hunter DJ. The androgen receptor CAG repeat polymorphism and risk of breast cancer in the Nurses' Health Study. Cancer Res 2002; 62(4): 1045-1049.Search in Google Scholar

Tut TG, Ghadessy FJ, Trifiro MA, Pinsky L, Yong EL. Long polyglutamine tracts in the androgen receptor are associated with reduced transactivation, impaired sperm production, and male infertility. J Clin Endocrinol Metab 1997; 82(11): 3777-3782.Search in Google Scholar

Efremov GD, Dimovski AJ, Plaseska-Karanfilska D, Simjanovska L, Sukarova E, Koceva S. Isolation of genomic DNA from mammalian cells. In: Efremov GD, Ed. A Laboratory Manual, 3rd ed. Skopje: Macedonian Academy of Sciences and Arts. 1999; 1-3.Search in Google Scholar

Tse JY, Liu VW, Yeung WS, Lau EY, Ng EH, Ho PC. Molecular analysis of the androgen receptor gene in Hong Kong Chinese infertile men. J Assist Reprod Genet 2003; 20(6): 227-233.10.1023/A:1024107528283Search in Google Scholar

Mifsud A, Sim CK, Boettger-Tong H, Moreira S, Lamb DJ, Lipshultz LI, Yong EL. Trinucleotide (CAG) repeat polymorphisms in the androgen receptor gene: molecular markers of risk for male infertility. Fertil Steril 2001; 75(2): 275-281.10.1016/S0015-0282(00)01693-9Search in Google Scholar

Komori S, Kasumi H, Kanazawa R, Sakata K, Nakata Y, Kato H, Koyama K. CAG repeat length in the androgen receptor gene of infertile Japanese males with oligozoospermia. Mol Hum Reprod 1999; 5(1):14-16.10.1093/molehr/5.1.14Search in Google Scholar

Dowsing AT, Yong EL, Clark M, McLachlan RI, de Kretser DM, Trounson AO. Linkage between male infertility and trinucleotide repeat expansion in the androgen-receptor gene. Lancet 1999; 354(9179): 640-643.10.1016/S0140-6736(98)08413-XSearch in Google Scholar

Kukuvitis A, Georgiou I, Bouba I, Tsirka A, Giannouli CH, Yapijakis C, Tarlatzis B, Bontis J, Lolis D, Sofikitis N, Papadimas J. Association of oestrogen receptor α polymorphisms and androgen receptor CAG trinucleotide repeats with male infertility: a study in 109 Greek infertile men. Int J Androl 2002; 25(3): 149-152.10.1046/j.1365-2605.2002.00339.x12031042Search in Google Scholar

Wallerand H, Remy-Martin A, Chabannes E, Bermont L, Adessi GL, Bittard H. Relationship between expansion of the CAG repeat in exon 1 of the androgen receptor gene and idiopathic male infertility. Fertil Steril 2001; 76(4): 769-774.10.1016/S0015-0282(01)01987-2Search in Google Scholar

Giwercman YL, Xu C, Arver S, Pousette A, Reneland R. No association between the androgen receptor gene CAG repeat and impaired sperm production in Swedish men. Clin Genet 1998; 54(5): 435-436.Search in Google Scholar

Lund A, Tapanainen JS, Lahdetie J, Savontaus ML, Aittomaki K. Long CAG repeats in the AR gene are not associated with infertility in Finnish males. Acta Obstet Gynecol Scand 2003; 82(2): 162-166.10.1034/j.1600-0412.2003.00068.xSearch in Google Scholar

Dadze S, Wieland C, Jakubiczka S, Funke K, Schroder E, Royer-Pokora B, Willers R, Wieacker PF. The size of the CAG repeat in exon 1 of the androgen receptor gene shows no significant relationship to impaired spermatogenesis in an infertile Caucasoid sample of German origin. Mol Hum Reprod 2000; 6(3): 207-214.10.1093/molehr/6.3.20710694266Search in Google Scholar

Thangaraj K, Joshi MB, Reddy AG, Gupta NJ, Chakravarty B, Singh L. CAG repeat expansion in the androgen receptor gene is not associated with male infertility in Indian populations. J Androl 2002; 23(6): 815-818.Search in Google Scholar

Ferlin A, Bartoloni L, Rizzo G, Roverato A, Garolla A, Foresta C. Androgen receptor gene CAG and GGC repeat lenghts in idiopathic male infertility. Mol Hum Reprod 2004; 10(6): 417-421.10.1093/molehr/gah05415044606Search in Google Scholar

Lavery R, Houghton JA, Nolana A, Glennon M, Egan D, Maher M. CAG repeat length in an infertile male population of Irish origin. Genetica 2005; 123(3): 295-302.10.1007/s10709-004-5091-815954500Search in Google Scholar