<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml">Commercial available lithium hydroxide monohydrate LiOH.H2O was found to be a novel ‘dual activation’ catalyst for tandem cross Knoevenagel condensation between malononitrile or ethylcyanoacetate and aromatic aldehydes leading to an efficient and easy synthesis of the corresponding arylidenes at room temperature in a short reaction time. In the case of salicyaldehyde the reaction lead to the formation of 3-substituted coumarins. The high efficacy, cheapness and easy availability of LiOH.H2O prompted us to investigate its validity as a basic catalyst for Gewald reaction.</abstract>

Commercial available lithium hydroxide monohydrate LiOH.H2O was found to be a novel ‘dual activation’ catalyst for tandem cross Knoevenagel condensation between malononitrile or ethylcyanoacetate and aromatic aldehydes leading to an efficient and easy synthesis of the corresponding arylidenes at room temperature in a short reaction time. In the case of salicyaldehyde the reaction lead to the formation of 3-substituted coumarins. The high efficacy, cheapness and easy availability of LiOH.H2O prompted us to investigate its validity as a basic catalyst for Gewald reaction.

LiOH.H2O as a catalyst for Knoevenagel and Gewald reactions

Chemistry Department, Faculty of Science, Mansoura University, Mansoura, 35516, Egypt

Polish Journal of Chemical Technology

LiOH.HO as a catalyst for Knoevenagel and Gewald reactions

Commercial available lithium hydroxide monohydrate LiOH.H2O was found to be a novel ‘dual activation’ catalyst for tandem cross Knoevenagel condensation...

LiOH.H₂O as a catalyst for Knoevenagel and Gewald reactions

Published Online: Dec 28, 2010

Page range: 31 - 35

DOI: https://doi.org/10.2478/v10026-010-0046-6

Keywords
Malononitrile, Ethylcyanoacetate, Cyclohexanone, LiOH.HO, Knoevenagel reaction, Gewald reaction

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