<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml">A simple, clean and environmentally benign route to the enantioselective synthesis of (<italic>S</italic>)-2-(6-methoxynaphtalen-2-yl)propanoic acid, (<italic>S</italic>)-Naproxen <bold>3</bold> is described by using Preyssler heteropolyacid, H14[NaP5W30O110], as a green and reusable catalyst in water and in the presence of 1-(6-methoxynaphthalen-2-yl)propan-1-one <bold>1</bold>, D-mannitol <bold>2</bold>. The products were obtained in very good yields.</abstract>

A simple, clean and environmentally benign route to the enantioselective synthesis of (S)-2-(6-methoxynaphtalen-2-yl)propanoic acid, (S)-Naproxen 3 is described by using Preyssler heteropolyacid, H14[NaP5W30O110], as a green and reusable catalyst in water and in the presence of 1-(6-methoxynaphthalen-2-yl)propan-1-one 1, D-mannitol 2. The products were obtained in very good yields.

One-pot synthesis of (<italic>S</italic>)-2-(6-methoxynaphtalen-2-yl)propanoic acid, (<italic>S</italic>)-Naproxen using Preyssler and Keggin-type heteropolyacids as green and reusable catalysts

Department of Chemistry, School of Science, Islamic Azad University, Mashhad, IRAN

Agricultural Researches and Services Center, Mashhad, IRAN

School of Pharmacy, Memorial University of Newfoundland, St. John's, Newfoundland, Canada A1C 3V6

Cluster for Molecular Chemistry, Department of Organic Chemistry, Radboud University Nijmegen, The Netherlands

Polish Journal of Chemical Technology

One-pot synthesis of ()-2-(6-methoxynaphtalen-2-yl)propanoic acid, ()-Naproxen using Preyssler and Keggin-type heteropolyacids as green and reusable catalysts

A simple, clean and environmentally benign route to the enantioselective synthesis of (S)-2-(6-methoxynaphtalen-2-yl)propanoic acid, (S)-Naproxen 3 is...

One-pot synthesis of (S)-2-(6-methoxynaphtalen-2-yl)propanoic acid, (S)-Naproxen using Preyssler and Keggin-type heteropolyacids as green and reusable catalysts

Published Online: Oct 09, 2009

Page range: 8 - 14

DOI: https://doi.org/10.2478/v10026-009-0029-7

Keywords
Preyssler, catalyst, heteropolyacid, D-mannitol, ()-Naproxen

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