Knockdown of stat3 expression by RNAi inhibits in vitro growth of human ovarian cancer

Klint A, Tryggvadóttir L, Bray F, Gislum M, Hakulinen T, Storm HH, et al. Trends in the survival of patients diagnosed with cancer in female genital organs in the Nordic countries 1964-2003 followed up to the end of 2006. Acta Oncol 2010; 49: 632-43.10.3109/02841861003691945Search in Google Scholar

Lenhard SM, Bufe A, Kümper C, Stieber P, Mayr D, Hertlein L, et al. Relapse and survival in early-stage ovarian cancer. Arch Gynecol Obstet 2009; 280: 71-7.10.1007/s00404-008-0877-zSearch in Google Scholar

Zhang Z, Zhou B, Zhang J, Chen Y, Lai T, Yan L, et al. Association of inter leukin-23 receptor gene polymorphisms with risk of ovarian cancer. Cancer Genet Cytogenet 2010; 196: 146-52.10.1016/j.cancergencyto.2009.09.006Search in Google Scholar

Shih leM, Davidson B. Pathogenesis of ovarian cancer: clues from selected overexpressed genes. Future Oncol 2009; 5: 1641-57.10.2217/fon.09.126Search in Google Scholar

Darnell JE Jr. STATs and gene regulation. Science 1997; 277: 1630- 5.10.1126/science.277.5332.1630Search in Google Scholar

Lu Y, Fukuyama S, Yoshida R, Kobayashi T, Saeki K, Shiraishi H, et al. Loss of SOCS3 gene expression converts STAT3 function from anti-apoptotic to proapoptotic. J Biol Chem 2006; 281: 36683-90.10.1074/jbc.M607374200Search in Google Scholar

Garcia R, Yu CL, Hudnall A, Catlett R, Nelson KL, Smithgall T, et al. Constitutive activation of STAT3 in fibroblasts transformed by diverse oncoproteins and in breast carcinoma cells. Cell Growth Differ 1997; 8: 1267-76.Search in Google Scholar

Garcia R, Bowman TL, Niu G, Yu H, Minton S, Muro-Cacho CA, et al. Constitutive activation of STAT3 by the Src and JAK tyrosine kinases participates in growth regulation of human breast carcinoma cells. Oncogene 2010; 20: 2499-513.10.1038/sj.onc.1204349Search in Google Scholar

Buettner R, Mora LB, Jove R. Activated STAT signaling in human tumors provides novel molecular targets for therapeutic intervention. Clin Cancer Res. 2002; 8: 945-54.Search in Google Scholar

Takemoto S, Mulloy JC, Cereseto A, Migone TS, Patel BK, Matsuoka M, et al. Proliferation of adult T cell leukemia/lymphoma cells is associated with the constitutive activation of JAK/STAT proteins. Proc Natl Acad Sci USA 1997; 94: 13897-902.10.1073/pnas.94.25.13897Search in Google Scholar

Gouilleux-Gruart V, Gouilleux F, Desaint C, Claisse JF, Capiod JC, Delobel J, et al. STAT-related transcription factors are constitutively activated in peripheral blood cells from acute leukemia patients. Blood 1996; 87: 1692-7.10.1182/blood.V87.5.1692.1692Search in Google Scholar

Levitzki A. Tyrosine kinases as targets for cancer therapy. Eur J Cancer 2002; 38: S11-8.10.1016/S0959-8049(02)80598-6Search in Google Scholar

Blaskovich MA, Sun J, Cantor A, Turkson J, Jove R, Sebti SM. Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice. Cancer Res 2003; 63: 1270-9.Search in Google Scholar

Bromberg J, Darnell JE Jr. The role of STATs in transcriptional control and their impact on cellular function. Oncogene 2000; 19: 2468-73.10.1038/sj.onc.1203476Search in Google Scholar

Leong PL, Andrews GA, Johnson DE, Dyer KF, Xi S, Mai JC, et al. Targeted inhibition of STAT3 with a decoy oligonucleotide abrogates head and neck cancer cell growth. Proc Natl Acad Sci USA 2003; 100: 4138-43.10.1073/pnas.0534764100Search in Google Scholar

Ni Z, Lou W, Leman ES, Gao AC. Inhibition of constitutively activated STAT3 signaling pathway suppresses growth of prostate cancer cells. Cancer Res 2000; 60: 1225-8.Search in Google Scholar

Zhang J, Shen B, Li Y, Sun Y. STAT3 exerts two-way regulation in the biological effects of IL-6 in M1 leukemia cells. Leuk Res 2001; 25: 463-72.10.1016/S0145-2126(00)00157-0Search in Google Scholar

Lee SO, Lou W, Qureshi KM, Mehraein-Ghomi F, Trump DL, et al. RNA interference targeting STAT3 inhibits growth and induces apoptosis of human prostate cancer cells. Prostate 2004; 60: 303-9.10.1002/pros.20072Search in Google Scholar

Konnikova L, Kotecki M, Kruger MM, Cochran BH. Knock-down of STAT3 expression by RNAi induces apoptosis in astrocytoma cells. BMC Cancer 2003; 3: 23.10.1186/1471-2407-3-23Search in Google Scholar

Mesojednik S, Kamensek U, Cemazar M. Evaluation of shRNA-mediated gene silencing by electroporation in LPB fibrosarcoma cells. Radiol Oncol 2008; 42: 82-92.10.2478/v10019-008-0007-3Search in Google Scholar

Grandis JR, Zheng Q, Drenning SD. Epidermal growth factor receptor-mediated stat3 signaling blocks apoptosis in head and neck cancer. Laryngoscope 2000; 110: 868-74.10.1097/00005537-200005000-00016Search in Google Scholar

Gao L, Zhang L, Hu J, Li F, Shao Y, Zhao D, et al. Down-regulation of signal transducer and activator of transcription 3 expression using vector-based small Interfering RNAs suppresses growth of human prostate tumor in vivo. Clin Cancer Res 2005; 11: 6333-41.10.1158/1078-0432.CCR-05-0148Search in Google Scholar

Fernandes A, Hamburger AW, Gerwin BI. ErbB-2 kinase is required for constitutive STAT3 activation in malignant human lung epithelial cells. Int J Cancer 1999; 83: 564-70.10.1002/(SICI)1097-0215(19991112)83:4<564::AID-IJC20>3.0.CO;2-QSearch in Google Scholar

Nagpal JK, Mishra R, Das BR. Activation of Stat3 as one of the early events in tobacco chewing-mediated oral carcinogenesis. Cancer 2002; 94: 2393-400.10.1002/cncr.10499Search in Google Scholar

Hsieh FC, Cheng G, Lin J. Evaluation of potential Stat3-regulated genes in human breast cancer. Biochem Biophys Res Commun 2005; 335: 292-99.10.1016/j.bbrc.2005.07.07516081048Search in Google Scholar

Rosen DG, Mercado-Uribe I, Yang G, Bast RC Jr, Amin HM, Lai R, et al. The role of constitutively active signal transducer and activator of transcription 3 in ovarian tumorigenesis and prognosis. Cancer 2006; 107: 2730-40.10.1002/cncr.2229317063503Search in Google Scholar

Cai L, Zhang G, Tong X, You Q, An Y, Wang Y, et al. Growth inhibition of human ovarian cancer cells by blocking STAT3 activation with small interfering RNA. Eur J Obstet Gynecol Reprod Biol 2010; 148: 73-80.10.1016/j.ejogrb.2009.09.01819880237Search in Google Scholar

Huang F, Tong X, Fu L, Zhang R. Knockdown of STAT3 by shRNA inhibits the growth of CAOV3 ovarian cancer cell line in vitro and in vivo. Acta Biochim Biophys Sin (Shanghai) 2008; 40: 519-25.10.1111/j.1745-7270.2008.00424.x18535750Search in Google Scholar

Ciardiello F, Tortora G. Inhibition of bcl-2 as cancer therapy. Ann Oncol 2002; 13: 501-2.10.1093/annonc/mdf19112056698Search in Google Scholar

Hayakawa Y, Hirata Y, Nakagawa H, Sakamoto K, Hikiba Y, Kinoshita H, et al. Apoptosis signal-regulating kinase 1 and cyclin D1 compose a positive feed-back loop contributing to tumor growth in gastric cancer. Proc Natl Acad Sci USA 2011; 108:780-5.10.1073/pnas.1011418108302103821187402Search in Google Scholar

Bressin C, Bourgarel-Rey V, Carré M, Pourroy B, Arango D, Braguer D, et al. Decrease in c-Myc activity enhances cancer cell sensitivity to vinblastine. Anticancer Drugs 2006; 17: 181-7.10.1097/00001813-200602000-0000916428936Search in Google Scholar