Digital ischemic events related to gemcitabine: Report of two cases and a systematic review

Dasanu CA. Gemcitabine: vascular toxicity and prothrombotic potential. Expert Opin Drug Saf 2008; 7: 703-16.10.1517/14740330802374262Search in Google Scholar

Summary of Product Characteristics of Gemcitabine; date of revision 18 February 2009: http://emc.medicines.org.uk/medicine/596Search in Google Scholar

Debevec L, Jeric T, Kovac V, Bitenc M, Sok M. Is there any progress in routine management of lung cancer patients? A comparative analysis of an institution in 1996 and 2006. Radiol Oncol 2009; 43: 47-53.10.2478/v10019-009-0008-xSearch in Google Scholar

Kovač V, Smrdel U. Meta-analyses of clinical trials in patients with non-small cell lung cancer. Neoplasma 2004; 51: 334-40.Search in Google Scholar

Izzedine H, Isnard-Bagnis C, Launay-Vacher V, Mercadal L, Tostivint I, Rixe O, et al. Gemcitabine-induced thrombotic microangiopathy: a systematic review. Nephrol Dial Transplant 2006; 21: 3038-45.10.1093/ndt/gfl507Search in Google Scholar

Kyung RH, Chan K, Un JP. Successful treatment of digital ulcers in a scleroderma patient with continuous infusion bilateral thoracic sympathetic block. Pain Physician 2008; 11: 91-6.Search in Google Scholar

Barcelo R, Lopez-Vivanco G, Mane JM, Rubio I, Munoz A, Fernandez R. Distal ischemic changes related to combination chemotherapy with cisplatin and gemcitabine. Description of four cases. Ann Oncol 2000; 11: 1191-4.10.1023/A:1008368019203Search in Google Scholar

Venat-Bouvet L, Szelag JC, Martin J, Labourey JL, Genet D, Tubiana-Mathieu N. Thrombotic microangiopathy and digital necrosis; two unrecognized toxicities of gemcitabine. Anticancer Drugs 2003; 14: 829-32.10.1097/00001813-200311000-00009Search in Google Scholar

Blaise S, Appeltants H, Carpentier PH and Debru JL. Digital ischemia and gemcitabine. Twoo new cases. J Mal Vasc 2005; 30: 53-7.10.1016/S0398-0499(05)83795-3Search in Google Scholar

Holstein A, Batge R, Egberts EH. Gemcitabine induced digital ischemia and necrosis. Eur J Cancer Care (Engl) 2009. [Epub ahead of print]Search in Google Scholar

Clowse MEB, Wigley FM. Digital necrosis related to carboplatin and gemcitabine therapy in systemic sclerosis. J Rheumatol 2003; 30: 1341-3.Search in Google Scholar

D'Alessandro V, Errico M, Varriale A, Greco A, De Cata A, Carnevale V, et al. Case report: acro-necrosis of the upper limbs caused by gemcitabine therapy. Cli Ter 2003; 154: 207-10.Search in Google Scholar

Hummers LK, Wigley FM. Management of Raynaud's phenomenon and digital ischemic lesions in scleroderma. Rheum Dis Clin North Am 2003; 29: 293-313.10.1016/S0889-857X(03)00019-XSearch in Google Scholar

Buch RS, Geisbüsch R, Kunkel M. Acral ischemia as a rare paraneoplastic syndrome in the terminal phase of mouth floor carcinoma. [German]. Mund Kiefer Gesichtschir 2002; 6: 331-5.10.1007/s10006-002-0399-y12448236Search in Google Scholar

Aschauer MA, Ebner F, Stollberger R. Advances in contrast-enhanced MR-angiography. Radiol Oncol 2002; 36: 103-8.Search in Google Scholar