Cysteine cathepsins and stefins in head and neck cancer: an update of clinical studies

Vokes EE, Weichselbyum RR, Lippman SM, Hong WK. Head and neck cancer. N Engl J Med 1993; 328:184-94.10.1056/NEJM199301213280306Search in Google Scholar

Strojan P. Cathepsins and their endogenous inhibitors in clinical oncology. Radiol Oncol 1996; 30: 120-33.Search in Google Scholar

Stoka V, Turk B, Turk V. Lysosomal cysteine cathepsins: signaling pathways in apoptosis. Biol Chem 2007; 388: 555-60.10.1515/BC.2007.064Search in Google Scholar

Kos J, Šmid L, Krašovec M, Svetic B, Lenarcic B, Vrhovec I, et al. Lysosomal proteases cathepsins D, B, H, L and their inhibitors stefins A and B in head and neck cancer. Biol Chem Hoppe Seyler 1995; 376: 401-5.10.1515/bchm3.1995.376.7.401Search in Google Scholar

Budihna M, Strojan P, Šmid L, Skrk J, Vrhovec I, Zupevc A, et al. Prognostic value of cathepsins B, H, L, D and their endogenous inhibitors stefins A and B in head and neck carcinoma. Biol Chem Hoppe Seyler 1996; 377: 385-90.10.1515/bchm3.1996.377.6.385Search in Google Scholar

Strojan P, Budihna M, Šmid L, Vrhovec I, Skrk J. Prognostic significance of cysteine proteinases B and L and their endogenous inhibitors stefins A and B in patients with squamous cell carcinoma of the head and neck. Clin Cancer Res 2000; 6: 1052-62.Search in Google Scholar

Strojan P, Oblak I, Svetic N, Šmid L, Kos J. Cysteine proteinase inhibitor cystatin C in squamous cell carcinoma of the head and neck: relation to prognosis. Br J Cancer 2004; 90: 1961-8.10.1038/sj.bjc.6601830Search in Google Scholar

Lah TT, Kos J, Blejec A, Frkovic-Georgio S, Golouh R, Vrhovec I, et al. The expression of lysosomal proteinases and their inhibitors in breast cancer: possible relationship to prognosis of the disease. Pathol Oncol Res 1997; 3: 89-99.10.1007/BF02907801Search in Google Scholar

Knoch H, Werle B, Ebert W, Spiess E. Imbalance between cathepsin B and cysteine proteinase inhibitors is of prognostic significance in human lung cancer. Int J Oncol 1994; 5: 77-85.10.3892/ijo.5.1.77Search in Google Scholar

Ebert E, Werle B, Jülke B, Kopitar-Jerala N, Kos J, Lah T, et al. Expression of cysteine proteinase inhibitors stefin A, stefin B, and cystatin C in human lung tumor tissue. Adv Exp Med Biol 1997; 421: 259-65.10.1007/978-1-4757-9613-1_34Search in Google Scholar

Look MP, van Putten WL, Duffy MJ, Harbeck N, Christensen IJ, Thomssen C, et al. Pooled analysis of prognostic impact of urokinase-type plasminogen activator and its inhibitor PAI-1 in 8377 breast cancer patients. J Natl Cancer Inst 2002; 94: 116-28.10.1093/jnci/94.2.116Search in Google Scholar

Kuopio T, Kankaanranta A, Jalava P, Kronqvist P, Kotkansalo T, Weber E, et al. Cysteine proteinase inhibitor cystatin A in breast cancer. Cancer Res 1998; 58: 432-6.Search in Google Scholar

Kos J, Krasovec M, Cimerman N, Nielsen HJ, Christensen IJ, Brunner N. Cysteine proteinase inhibitors stefin A, stefin B, and cystatin C in sera from patients with colorectal cancer: relation to prognosis. Clin Cancer Res 2000; 6: 505-11.Search in Google Scholar

Kos J, Lah T. Role of cystatins and stefins in cancer. In: Zerovnik E, Kopitar-Jerala N, Uversky V, editors. Human stefins and cystatins. New York: Nova Science Publishers, Inc; 2006. p. 233-6.Search in Google Scholar

Levičar N, Kos J, Blejec A, Golouh R, Vrhovec I, Frkovic-Grazio S, et al. Comparison of potential biological markers cathepsin B, cathepsin L, stefin A and stefin B with urokinase and plasminogen activator inhibitor-1 and clinicopathological data of breast carcinoma patients. Cancer Detect Prev 2002; 26: 42-9.10.1016/S0361-090X(02)00015-6Search in Google Scholar

Lah TT, Kalman E, Najjar D, Gorodetsky E, Brennan P, Somers R, et al. Cells producing cathepsins D, B and L in human breast carcinoma and their association with prognosis. Hum Pathol 2000; 3: 149-60.10.1016/S0046-8177(00)80214-2Search in Google Scholar

Kręcicki T, Siewiński M. Serum cathepsin B-like activity as a potential marker of laryngeal carcinoma. Eur Arch Otorhinolaryngol 1992; 249: 293-5.10.1007/BF00714496Search in Google Scholar

Bongers V, Konings CH, Grijpma AM, Steen I, Braakhuis BJM, Snow GB. Serum proteinase activities in head and neck squamous cell carcinoma patients. Anticancer Res 1995; 15: 2763-6.Search in Google Scholar

Strojan P, Budihna M, Šmid L, Svetic B, Vrhovec I, Škrk J. Cathepsin B and L and stefin A and B levels as serum tumor markers in squamous cell carcinoma of the head and neck. Neoplasma 2001; 48: 66-71.Search in Google Scholar

Strojan P, Budihna M, Šmid L, Svetic B, Vrhovec I, Kos J, et al. Cathepsin H in squamous cell carcinoma of the head and neck. Radiol Oncol 1999; 33: 143-51.Search in Google Scholar

Siewiński M, Kręcicki T, Jarmułowicz J, Berdowska I. Cysteine proteinase inhibitors in serum of patients with head and neck tumors. Diagn Oncol 1992; 2: 323-6.Search in Google Scholar

Strojan P, Svetic B, Šmid L, Kos J. Serum cystatin C in patients with head and neck carcinoma. Clin Chim Acta 2004; 344: 155-61.10.1016/j.cccn.2004.02.011Search in Google Scholar

Vigneswaran N, Zhao W, Dassanayake A, Muller S, Miller DM, Zacharias W. Variable expression of cathepsin B and D correlates with highly invasive and metastatic phenotype of oral cancer. Hum Pathol 2000; 31: 931-7.10.1053/hupa.2000.9035Search in Google Scholar

Macabeo-Ong M, Shiboski CH, Silverman S, Ginzinger DG, Dekker N, Wong DT, et al. Quantitative analysis of cathepsin L mRNA and protein expression during oral cancer progression. Oral Oncol 2003; 39: 638-47.10.1016/S1368-8375(03)00034-4Search in Google Scholar

Nikitakis NG, Rivera H, Lopes MA, Siavash H, Reynolds MA, Ord RA, et al. Immunohistochemical expression of angiogenesis-related markers in oral squamous cell carcinoma with multiple metastatic lymph nodes. Am J Clin Pathol 2003; 119: 574-86.10.1309/JD3DHGCDGAUN1R0JSearch in Google Scholar

Kawasaki G, Kato Y, Mizuno A. Cathepsin expression in oral squamous cell carcinoma: Relationship with clinicopathologic factors. Orla Surg Oral Med Oral Patol Oral Radiol Endod 2002; 93: 446-54.10.1067/moe.2002.122834Search in Google Scholar

Strojan P, Aničin A, Svetic B, Pohar M, Šmid L, Kos J. Stefin A and stefin B: markers for prognosis in inoperable squamous cell carcinoma of the head and neck. Int J Radiat Oncol Biol Phys 2007; 68: 1335-41.10.1016/j.ijrobp.2007.02.004Search in Google Scholar

Bossard N, Descotes F, Bremond AG, Bobin Y, De Saint Hilaire P, Golfier F, et al. Keeping data continuous when analyzing the prognostic impact of the tumor marker: an example with cathepsin D in breast cancer. Breast Cancer Res Treat 2003;82:47-59.10.1023/B:BREA.0000003919.75055.e8Search in Google Scholar

Castiglioni T, Merino MJ, Elsner B, Lah TT, Sloane BF, Emmert-Buck MR. Immunohistochemical analysis of cathepsin D, B and L in human breast cancer. Hum Pathol 1994; 25: 857-62.10.1016/0046-8177(94)90003-5Search in Google Scholar

Strojnik T, Židanik B, Kos J, Lah TT. Cathepsin B and L are markers for clinically invasive types of meningeomas. Neurosurgery 2001; 48: 598-605.10.1097/00006123-200103000-00029Search in Google Scholar

Sinha AA, Quast BJ, Wilson MJ, Fernandes ET, Reddy PK, Ewing SL, et al. Prediction of pelvic lymph node metastasis by the ratio of cathepsin B to stefin A in patients with prostate carcinoma. Cancer 2002; 94: 3141-9.10.1002/cncr.10604Search in Google Scholar

Kim R, Emi M, Tanabe K, Uchida Y, Arihiro K. The role of apoptotic or nonapoptotic cell death in determining cellular response to anticancer treatment. Eur J Surg Oncol 2006; 32: 269-77.10.1016/j.ejso.2005.12.006Search in Google Scholar

Johansson AC, Norberg-Spaak L, Roberg K. Role of lysosomal cathepsins in napthazarin- and Fasinduced apoptosis in oral squamous cell carcinoma cells. Acta Oto-Laryngol 2006; 126: 70-81.10.1080/00016480510043422Search in Google Scholar

Osmak M, Svetic B, Gabrijelčič-Geiger, Skrk J. Drug-resistant human laryngeal carcinoma cells have increased levels of cathepsin B. Anticancer Res 2001; 21: 481-4.Search in Google Scholar

Zajc I, Hreljac I, Lah T. Cathepsin L affects apoptosis of glioblastoma cells: a potential implication in the design of cancer therapeutics. Anticancer Res 2006; 26: 3357-64.Search in Google Scholar

Gewies A, Grimm S. Cathepsin-B and cathepsin-L expression levels do not correlate with sensitivity of tumor cells to TNF-alpha-mediated apoptosis. Br J Cancer 2003; 89: 1574-80.10.1038/sj.bjc.6601297Search in Google Scholar

Nagaraj NS, Vigneswaran N, Zacharias W. Hypoxia inhibits TRAIL-induced tumor cell apoptosis: involvement of lysosomal cathepsins. Apoptosis 2007; 12: 125-39.10.1007/s10495-006-0490-1Search in Google Scholar

Wickramasinghe NS, Banerjee K, Nagaraj NS, Vigneswaran N, Zacharias W. Hypoxia alters cathepsin B/inhibitor profiles in oral carcinoma cell lines. Anticancer Res 2005; 25: 2841-9.Search in Google Scholar

Horsman MR. Measurement of tumor oxygenation. Int J Radiat Oncol Biol Phys 1998; 42: 701-4.10.1016/S0360-3016(98)00332-0Search in Google Scholar

Strojnik T, Kos J, Židanik B, Golouh R, Lah T. Cathepsin B immunohistochemical staining in tumor and endothelial cells is a new prognostic factor for survival in patients with brain tumors. Clin Cancer Res 1999; 5: 559-67.Search in Google Scholar

Campo E, Munoz J, Miquel R, Palacín A, Cardesa A, Sloane BF. Cathepsin B expression in colorectal carcinomas correlates with tumor progression and shortened patient survival. Am J Pathol 1994; 145: 301-9.Search in Google Scholar

Elzagheid A, Kuopio T, Pyrhönen S, Collan Y. Lymph node status as a guide to selection of available prognostic markers in breast cancer: the clinical practice of the future? Diagn Pathol 2006; 1: 41.10.1186/1746-1596-1-41165418717092354Search in Google Scholar