<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml">In this study, polysaccharides were isolated from <italic>Ganoderma lucidum (Polyporaceae)</italic> and their antitumor and anti-inflammatory activities were investigated using <italic>in vivo</italic> models. Potential antitumor activity was shown by <italic>G. lucidum</italic> polysaccharides (GLP) against solid tumor induced by Ehrlich's ascites carcinoma cells. GLP at 100 mg kg-1 body mass showed 80.8 and 77.6 % reduction in tumour volume and tumour mass, respectively, when administered 24 h after tumour implantation. Again, GLP at the same dose but when administered prior to tumour inoculation, showed 79.5 and 81.2 % inhibition of tumour volume and tumour mass, respectively. GLP showed significant dose-dependent activity in carrageenean-induced (acute) and formalin-induced (chronic) inflammation assays. At 100 mg kg-1, GLP exhibited 57.6 and 58.2 % inhibition in carrageenean-induced and formalin-induced assays, respectively.</abstract>

In this study, polysaccharides were isolated from Ganoderma lucidum (Polyporaceae) and their antitumor and anti-inflammatory activities were investigated using in vivo models. Potential antitumor activity was shown by G. lucidum polysaccharides (GLP) against solid tumor induced by Ehrlich's ascites carcinoma cells. GLP at 100 mg kg-1 body mass showed 80.8 and 77.6 % reduction in tumour volume and tumour mass, respectively, when administered 24 h after tumour implantation. Again, GLP at the same dose but when administered prior to tumour inoculation, showed 79.5 and 81.2 % inhibition of tumour volume and tumour mass, respectively. GLP showed significant dose-dependent activity in carrageenean-induced (acute) and formalin-induced (chronic) inflammation assays. At 100 mg kg-1, GLP exhibited 57.6 and 58.2 % inhibition in carrageenean-induced and formalin-induced assays, respectively.

Antitumor and anti-inflammatory activities of polysaccharides isolated from <italic>Ganoderma lucidum</italic>

Phytochemistry and Phytopharmacology Division, Tropical Botanic Garden and Research Institute, Palode Thiruvananthapuram-695562, India

Amala Cancer Research Centre, Amala Nagar, Thrissur-680555, India

Amity Institute for Herbal and Biotech Products Development, Peroorkada Thiruvananthapuram-695005, India

Acta Pharmaceutica

Antitumor and anti-inflammatory activities of polysaccharides isolated from 

In this study, polysaccharides were isolated from Ganoderma lucidum (Polyporaceae) and their antitumor and anti-inflammatory activities were investigated using...

Antitumor and anti-inflammatory activities of polysaccharides isolated from Ganoderma lucidum

Published Online: Sep 26, 2011

Page range: 335 - 342

DOI: https://doi.org/10.2478/v10007-011-0030-6

Keywords
Ganoderma lucidum (Polyporaceae), polisaharidi, protuupalno djelovanje, citostatsko djelovanje

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