<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml"><p>Bovine serum albumin (BSA) nanoparticles loaded with paclitaxel (PTX) were prepared using a desolvation technique. A 3<sup>2</sup> full factorial design (FFD) was employed to formulate nanoparticles. Nanoparticles were characterized for particle size by photon correlation spectroscopy and surface morphology by scanning electron microscopy (SEM) and transmission electron microscopy (TEM). Encapsulation efficiency, zeta potential and particle yield were also determined. Response surface linear modelling (RSLM) was used to predict the optimal formulation. Various models were applied to determine the release mechanism from PTX nanoparticles. The effect of drug-polymer ratio on the release profile of formulations was observed and was applied to determine the suitability of the predicted optimal formulation. A preliminary study to determine the feasibility of targeting the prepared nanoparticles to brain was also carried out using mice as <italic>in vivo</italic> models.</p></abstract>

Bovine serum albumin (BSA) nanoparticles loaded with paclitaxel (PTX) were prepared using a desolvation technique. A 32 full factorial design (FFD) was employed to formulate nanoparticles. Nanoparticles were characterized for particle size by photon correlation spectroscopy and surface morphology by scanning electron microscopy (SEM) and transmission electron microscopy (TEM). Encapsulation efficiency, zeta potential and particle yield were also determined. Response surface linear modelling (RSLM) was used to predict the optimal formulation. Various models were applied to determine the release mechanism from PTX nanoparticles. The effect of drug-polymer ratio on the release profile of formulations was observed and was applied to determine the suitability of the predicted optimal formulation. A preliminary study to determine the feasibility of targeting the prepared nanoparticles to brain was also carried out using mice as in vivo models.

Design and development of paclitaxel-loaded bovine serum albumin nanoparticles for brain targeting

UGC-Centre for Advanced Studies University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh-160014 India

Hindu College of Pharmacy, Sonepat, Haryana, India

Acta Pharmaceutica

Bovine serum albumin (BSA) nanoparticles loaded with paclitaxel (PTX) were prepared using a desolvation technique. A 32 full factorial design (FFD) was...

Design and development of paclitaxel-loaded bovine serum albumin nanoparticles for brain targeting

Published Online: Jun 17, 2011

Page range: 141 - 156

DOI: https://doi.org/10.2478/v10007-011-0012-8

Keywords
paklitaksel, goveđi serumski albumin, nanočestice, desolvatacija, ciljano djelovanje na mozak, faktorijalno dizajniranje

This content is open access.

Design and development of paclitaxel-loaded bovine serum albumin nanoparticles for brain targeting

Published Online: Jun 17, 2011

Page range: 141 - 156

DOI: https://doi.org/10.2478/v10007-011-0012-8

Keywordspaklitaksel, goveđi serumski albumin, nanočestice, desolvatacija, ciljano djelovanje na mozak, faktorijalno dizajniranje

This content is open access.

Keywords
paklitaksel, goveđi serumski albumin, nanočestice, desolvatacija, ciljano djelovanje na mozak, faktorijalno dizajniranje