<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml"><p>The objective of the investigation was to study the effect of bromhexine hydrochloride (BXH) content and agglomerate size on mechanical, compressional and drug release properties of agglomerates prepared by crystallo-co-agglomeration (CCA). Studies on optimized batches of agglomerates (BXT1 and BXT2) prepared by CCA have showed adequate sphericity and strength required for efficient tabletting. Trend of strength reduction with a decrease in the size of agglomerates was noted for both batches, irrespective of drug loading. However, an increase in mean yield pressure (14.189 to 19.481) with an increase in size was observed for BXT2 having BXH-talc (1:15.7). Surprisingly, improvement in tensile strength was demonstrated by compacts prepared from BXT2, due to high BXH load, whereas BXT1, having a low amount of BXH (BXH-talc, 1:24), showed low tensile strength. Consequently, increased tensile strength was reflected in extended drug release from BXT2 compacts (Higuchi model, <italic>R<sup>2</sup></italic> = 0.9506 to 0.9981). Thus, it can be concluded that interparticulate bridges formed by BXH and agglomerate size affect their mechanical, compressional and drug release properties.</p></abstract>

The objective of the investigation was to study the effect of bromhexine hydrochloride (BXH) content and agglomerate size on mechanical, compressional and drug release properties of agglomerates prepared by crystallo-co-agglomeration (CCA). Studies on optimized batches of agglomerates (BXT1 and BXT2) prepared by CCA have showed adequate sphericity and strength required for efficient tabletting. Trend of strength reduction with a decrease in the size of agglomerates was noted for both batches, irrespective of drug loading. However, an increase in mean yield pressure (14.189 to 19.481) with an increase in size was observed for BXT2 having BXH-talc (1:15.7). Surprisingly, improvement in tensile strength was demonstrated by compacts prepared from BXT2, due to high BXH load, whereas BXT1, having a low amount of BXH (BXH-talc, 1:24), showed low tensile strength. Consequently, increased tensile strength was reflected in extended drug release from BXT2 compacts (Higuchi model, R2 = 0.9506 to 0.9981). Thus, it can be concluded that interparticulate bridges formed by BXH and agglomerate size affect their mechanical, compressional and drug release properties.

Effect of drug content and agglomerate size on tabletability and drug release characteristics of bromhexine hydrochloridetalc agglomerates prepared by crystallo-co-agglomeration

Department of Pharmaceutics, Bharati Vidyapeeth College of Pharmacy, Kolhapur-416013 Maharashtra State, India

Department of Pharmaceutics Poona College of Pharmacy, Bharati Vidyapeeth University Erandwane, Pune-411038 Maharashtra State, India

Institute of Pharmaceutical Innovation, University of Bradford, Bradford West Yorkshire, United Kingdom BD7 1DP

Acta Pharmaceutica

The objective of the investigation was to study the effect of bromhexine hydrochloride (BXH) content and agglomerate size on mechanical, compressional and drug...

Effect of drug content and agglomerate size on tabletability and drug release characteristics of bromhexine hydrochloridetalc agglomerates prepared by crystallo-co-agglomeration

Published Online: Mar 13, 2010

Page range: 25 - 38

DOI: https://doi.org/10.2478/v10007-010-0002-2

Keywords
kristalokoaglomeracija, veličina aglomerata, sadržaj ljekovite tvari, kompresija, produljeno oslobadanje

This content is open access.

Effect of drug content and agglomerate size on tabletability and drug release characteristics of bromhexine hydrochloridetalc agglomerates prepared by crystallo-co-agglomeration

Published Online: Mar 13, 2010

Page range: 25 - 38

DOI: https://doi.org/10.2478/v10007-010-0002-2

Keywordskristalokoaglomeracija, veličina aglomerata, sadržaj ljekovite tvari, kompresija, produljeno oslobadanje

This content is open access.

Keywords
kristalokoaglomeracija, veličina aglomerata, sadržaj ljekovite tvari, kompresija, produljeno oslobadanje