<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml">The objective of the present work was to develop a suitable transdermal drug delivery system for nitrendipine. Polymeric films of nitrendipine were prepared by the film casting technique (glass ring) on mercury substrate. They were evaluated for physicochemical parameters, <italic>in vitro</italic> release and <italic>ex vivo</italic> permeation (heat separated human epidermis). Release of the drug from the films followed anomalous transport (0.5 &lt; <italic>n</italic> &lt; 1).Polymeric combination containing Eudragit RL 100:PVP K 30 in a 4:6 ratio showed the best results. Maximum drug release and skin permeability coefficient in 48 h were 85.8% and 0.0142 cm h-1, respectively, in formulation C3 (Eudragit RL 100/Plasdone S 630; 4:6) and 88.0% and 0.0155 cm h-1, respectively, in formulation, D3 (Eudragit RL 100/PVP K 30; 4:6). FTIR and TLC studies indicated no drug and polymer interaction.</abstract>

The objective of the present work was to develop a suitable transdermal drug delivery system for nitrendipine. Polymeric films of nitrendipine were prepared by the film casting technique (glass ring) on mercury substrate. They were evaluated for physicochemical parameters, in vitro release and ex vivo permeation (heat separated human epidermis). Release of the drug from the films followed anomalous transport (0.5 < n < 1).Polymeric combination containing Eudragit RL 100:PVP K 30 in a 4:6 ratio showed the best results. Maximum drug release and skin permeability coefficient in 48 h were 85.8% and 0.0142 cm h-1, respectively, in formulation C3 (Eudragit RL 100/Plasdone S 630; 4:6) and 88.0% and 0.0155 cm h-1, respectively, in formulation, D3 (Eudragit RL 100/PVP K 30; 4:6). FTIR and TLC studies indicated no drug and polymer interaction.

Formulation and evaluation of monolithic matrix polymer films for transdermal delivery of nitrendipine

ITS-Paramedical (Pharmacy) College, Ghaziabad, India

D. J. College of Pharmacy, Ghaziabad, India

Deparment of Pharmaceutics, Faculty of Pharmacy, Hamdard University, New Delhi, India

Acta Pharmaceutica

The objective of the present work was to develop a suitable transdermal drug delivery system for nitrendipine. Polymeric films of nitrendipine were prepared by...

Formulation and evaluation of monolithic matrix polymer films for transdermal delivery of nitrendipine

Published Online: Nov 16, 2009

Page range: 383 - 393

DOI: https://doi.org/10.2478/v10007-009-0032-9

Keywords
polimerni film, nitrendipin, transdermalni sustav za isporuku lijekova, Eudragit RL 100, Plasdone S 630, PVP K 30

This content is open access.

Formulation and evaluation of monolithic matrix polymer films for transdermal delivery of nitrendipine

Published Online: Nov 16, 2009

Page range: 383 - 393

DOI: https://doi.org/10.2478/v10007-009-0032-9

Keywordspolimerni film, nitrendipin, transdermalni sustav za isporuku lijekova, Eudragit RL 100, Plasdone S 630, PVP K 30

This content is open access.

Keywords
polimerni film, nitrendipin, transdermalni sustav za isporuku lijekova, Eudragit RL 100, Plasdone S 630, PVP K 30