<abstract xml:lang="en" xmlns="http://www.w3.org/1999/xhtml">This study sought to determine the potential prophylactic and antioxidant effects of aminoguanidine in experimentally induced diabetes. Four groups of Wistar rats, each composed of ten rats, were used. Two groups served as control. In group 3, diabetes was induced by a single intraperitoneal injection of streptozotocin (65 mg kg-1). In group 4, diabetes was induced and treated with aminoguanidine (100 mg kg-1 daily) orally for 3 months. Levels of serum glucose, glutathione peroxidase, glutathione reductase and erythrocytes catalase were analyzed on day 90 of the experiment. Retinal and kidney specimens were examined histopathologically after sacrifice of the animals. A significant antioxidant effect of aminoguanidine and its prophylactic role in diabetic retinopathy and nephropathy were observed in experimental animals.</abstract>

This study sought to determine the potential prophylactic and antioxidant effects of aminoguanidine in experimentally induced diabetes. Four groups of Wistar rats, each composed of ten rats, were used. Two groups served as control. In group 3, diabetes was induced by a single intraperitoneal injection of streptozotocin (65 mg kg-1). In group 4, diabetes was induced and treated with aminoguanidine (100 mg kg-1 daily) orally for 3 months. Levels of serum glucose, glutathione peroxidase, glutathione reductase and erythrocytes catalase were analyzed on day 90 of the experiment. Retinal and kidney specimens were examined histopathologically after sacrifice of the animals. A significant antioxidant effect of aminoguanidine and its prophylactic role in diabetic retinopathy and nephropathy were observed in experimental animals.

Potential prophylactic role of aminoguanidine in diabetic retinopathy and nephropathy in experimental animals

Department of Pharmacology, Institute of Ophthalmology, Giza, Egypt

Biochemistry, Institute of Ophthalmology, Giza, Egypt

Histology Research, Institute of Ophthalmology, Giza, Egypt

Acta Pharmaceutica

This study sought to determine the potential prophylactic and antioxidant effects of aminoguanidine in experimentally induced diabetes. Four groups of Wistar...

Potential prophylactic role of aminoguanidine in diabetic retinopathy and nephropathy in experimental animals

Published Online: Mar 20, 2009

Page range: 67 - 73

DOI: https://doi.org/10.2478/v10007-009-0009-8

Keywords
aminogvanidin, diabetička retinopatija, nefropatija, dušikov oksid, glikozilirani krajnji produkt, antioksidansi

This content is open access.

Potential prophylactic role of aminoguanidine in diabetic retinopathy and nephropathy in experimental animals

Published Online: Mar 20, 2009

Page range: 67 - 73

DOI: https://doi.org/10.2478/v10007-009-0009-8

Keywordsaminogvanidin, diabetička retinopatija, nefropatija, dušikov oksid, glikozilirani krajnji produkt, antioksidansi

This content is open access.

Keywords
aminogvanidin, diabetička retinopatija, nefropatija, dušikov oksid, glikozilirani krajnji produkt, antioksidansi