Open Access

Synthesis and pharmacological evaluation of 3-cyclohexyl-2-substituted hydrazino-3H-quinazolin-4-ones as analgesic and anti-inflammatory agents


Cite

J. van Ryn and R. M. Botting, New insights into the mode of action of anti-inflammatory drugs, Inflamm. Res. 44 (1995) 1-10; DOI: 10.1007/BF01630479.10.1007/BF016304797664022Search in Google Scholar

J. van Ryn, G. Trummlitz and M. Pairet, COX-2 selectivity and inflammatory processes, Curr. Med. Chem. 7 (2000) 1145-1161.10.2174/092986700337425511032964Search in Google Scholar

J. van Ryn, Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs, Nature: New Biol. 231 (1971) 232-235.10.1038/newbio231232a05284360Search in Google Scholar

M. Beuck, Nonsteroidal antiinflammatory drugs: A new generation of cyclooxygenase inhibitors, Angew. Chem. Int. Ed. 38 (1999) 631-633; DOI: 10.1002/(SICI)1521-3773(19990301)38:5<631:: AID-ANIE631>3.0.CO;2-S.Search in Google Scholar

V. Alagarsamy, R. Revathi, S. Vijayakumar and K. V. Ramseshu, Synthesis and pharmacological investigation of some novel 2,3-disubstituted quinazolin-4(3H)-ones as analgesic and antiinflammatory agents, Pharmazie 58 (2003) 233-236; DOI: 10.1002/chin.200330182.10.1002/chin.20033018212749402Search in Google Scholar

V. Alagarsamy, A. Thangathirupathy, S. C. Mandal, S. Rajasekaran, S. Vijayakumar, R. Revathi, J. Anburaj, S. Arunkumar and S. Rajesh, Pharmacological evaluation of 2-substituted (1,3,4) thiadiazolo quinazolines, Indian J. Pharm. Sci. 68 (2006) 108-111.10.4103/0250-474X.22980Search in Google Scholar

A. E. Abdel-Rahman, E. A. Bakhite and E. A. Al-Taifi, Synthesis and antimicrobial testing of some new S-substituted-thiopyridines, thienopyridines, pyridothienopyrimidines and pyridothienotriazines, Pharmazie 58 (2003) 372-377; DOI: 10.1002/chin.200330182.10.1002/chin.200330182Search in Google Scholar

R. V. Chambhare, B. G. Khadse, A. S. Bobde and R. H. Bahekar, Synthesis and preliminary evaluation of some N-[5-(2-furanyl)-2-methyl-4-oxo-4H-thieno[2,3-d]pyrimidin-3-yl]-carboxamide and 3-substituted-5-(2-furanyl)-2-methyl-3H-thieno[2,3-d]pyrimidin-4-ones as antimicrobial agents, Eur. J. Med. Chem. 38 (2003) 89-100; DOI: 10.1002/chin.200328177.10.1002/chin.200328177Search in Google Scholar

N. A. Santagati, A. Caruso, V. M. C. Cutuli and F. Caccamo, Synthesis and pharmacological evaluation of thieno[2,3-d]pyrimidin-2,4-dione and 5H-pyrimido [5,4-b]indol-2,4-dione derivatives, Farmaco 50 (1995) 689-695.Search in Google Scholar

V. Alagarsamy, V. R. Solomon, G. Vanikavitha, V. Paluchamy, M. R. Chandran, A. A. Sujin, A. Thangathiruppathy, S. Amuthalakshmi and R. Revathi, Synthesis, analgesic, anti-inflammatory and antibacterial activities of some novel 2-phenyl-3-substituted quinazolin-4(3H) ones, Biol. Pharm. Bull. 25 (2002) 1432-1435; DOI: 10.1248/bpb.25.1432.10.1248/bpb.25.143212419954Search in Google Scholar

V. Alagarsamy, G. Murugananthan and R. Venkateshperumal, Synthesis, analgesic, anti-inflammatory and antibacterial activities of some novel 2-methyl-3-substituted quinazolin-4-(3H)-ones, Biol. Pharm. Bull. 26 (2003) 1711-1714; DOI: 10.1248/bpb.26.1711.10.1248/bpb.26.171114646176Search in Google Scholar

V. Alagarsamy, R. Rajesh, R. Meena, S. Vijaykumar, K. V. Ramseshu and T. Duraianandakumar, Synthesis, analgesic, anti-inflammatory and antibacterial activities of some novel 2-methylthio-3-substituted quinazolin-4(3H)-ones, Biol. Pharm. Bull. 27 (2004) 652-656; DOI: 10.1248/bpb.27.652.10.1248/bpb.27.65215133239Search in Google Scholar

V. Alagarsamy, V. Muthukumar, N. Pavalarani, P. Vasanthanathan and R. Revathi, Synthesis, analgesic and anti-inflammatory activities of some novel 2,3-disubstituted quinazolin-4(3H)-ones, Biol. Pharm. Bull. 26 (2003) 557-559; DOI: 10.1248/bpb.26.557.10.1248/bpb.26.557Search in Google Scholar

S. K. Kulkarni, Heat and other physiological stress-induced analgesia: Catecholamine mediated and naloxone reversible response, Life Sci. 27 (1980) 185-188; DOI: 10.1016/0024-3205(80)90136-8.10.1016/0024-3205(80)90136-8Search in Google Scholar

R. E. Amour and D. L. Smith, A method for determinating loss of pain sensation. J. Pharm. Exp. Ther. 72 (1941) 74-78.Search in Google Scholar

C. A. Winter, E. A. Risely and G. W. Nuss, Carregeenin induced oedema in hind paw of the rat as assay for antiinflammatory drugs, Exp. Biol. Med. 111 (1962) 544-547.10.3181/00379727-111-2784914001233Search in Google Scholar

R. K. Goyal, A. Chakrabarti and A. K. Sanyal, The effect of biological variables on the anti-ulcerogenic effect of vegetable plantain banana, Planta Med. 29 (1985) 85-88; DOI: 10.1055/s-2007-969412.10.1055/s-2007-9694124034739Search in Google Scholar

M. Shay, S. A. Komarov, D. Fels, D. Meranze, H. Grunstein and H. Siplet, A simple method for the uniform production of gastric ulceration in the rats, Gastroenterology 5 (1945) 43-61.Search in Google Scholar

A. K. Ganguly and O. P. Bhatnagar, Effect of bilateral adrenalectomy on production of restraint ulcers in the stomach of albino rats, Can. J. Phys. Pharmacol. 51 (1973) 748-750.10.1139/y73-1134753287Search in Google Scholar

eISSN:
1846-9558
ISSN:
1330-0075
Language:
English
Publication timeframe:
4 times per year
Journal Subjects:
Pharmacy, other