Predictive factors for live birth in autologous in vitro fertilization cycles in women aged 40 years and older
and | Oct 01, 2019
About this article
Article Category: Original scientific article
Published Online: Oct 01, 2019
Page range: 173 - 178
Received: Nov 07, 2018
Accepted: Aug 08, 2019
DOI: https://doi.org/10.2478/sjph-2019-0022
Keywords
© 2019 National Institute of Public Health, Slovenia
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.
Comparison of patients and cycles characteristics between successful and unsuccessful IVF/ICSI cycles in women ≥40.
| Live birth NO | Live birth YES | P-value | |
|---|---|---|---|
| No. of cycles | 1730 | 190 | |
| Age (years) | 41.26±1.18 | 40.78±0.90 | <0.001 |
| No. of previous cycles | 2.80±3.12 | 2.06±2.02 | 0.001 |
| Only male infertility (%) | 33.29 | 31.58 | NS |
| Only female infertility (%) | 15.37 | 15.79 | NS |
| Male and female infertility (%) | 24.81 | 28.72 | NS |
| Unexplained infertility (%) | 26.53 | 27.89 | NS |
| ICSI (%) | 80.38 | 77.11 | NS |
| Total FSH dose (IU x 75) | 36.40±14.64 | 35.87±11.56 | NS |
| Duration of stimulation (days) | 9.63±3.17 | 10.03±2.31 | NS |
| No. of oocytes | 5.77±4.57 | 7.84±4.87 | <0.001 |
| No. of embryos | 3.55±2.81 | 5.29±3.03 | <0.001 |
| No. of good quality embryos on day2 | 2.01±2.22 | 3.60±2.75 | 0.001 |
| No. of embryos transferred | 1.84±0.71 | 2.01±0.55 | <0.001 |
| Day 5 embryo transfer (%) | 17.26 | 40.21 | <0.001 |
| No. of frozen blastocysts | 0.30±0.98 | 1.03±1.68 | <0.001 |
| Duration of stimulation (days) | 9.63±3.17 | 10.03±2.31 | NS |
Multivariable logistic regression analyses assessing predictors of live birth after IVF/ICSI in women ≥40 years.
| 42 years | 43 years | 44 years | ≥45 years | |
|---|---|---|---|---|
| Age (years) | -0.41 | 0.08 | <0.001 | 0.66 (0.55-0.78) |
| No. of previous cycles | -0.12 | 0.04 | 0.001 | 0.88 (0.82-0.95) |
| No. of oocytes | 0.05 | 0.04 | 0.22 | 0.95 (0.88-1.03) |
| No. of embryos | 0.001 | 0.09 | 0.98 | 0.99 (0.82-1.20) |
| No. of good quality embryos on day 2 | 0.18 | 0.06 | 0.005 | 1.19 (1.05-1.36) |
| No. of embryos transferred | 0.45 | 0.14 | 0.002 | 1.57 (1.19-2.07) |
| Day 5 embryo transfer (%) | 0.79 | 0.24 | 0.001 | 2.21 (1.37-3.55) |
Outcome of IVF/ICSI cycles by age in women ≥40 years of age.
| 40 years | 41 years | 42 years | 43 years | 44 years | ≥45 years | |
|---|---|---|---|---|---|---|
| No. of cycles | 640 | 556 | 489 | 143 | 69 | 23 |
| No. of embryo-transfers | 539 | 465 | 401 | 113 | 53 | 19 |
| No. of pregnancies (%) | 129 (23.9) | 85 (18.3) | 49 (12.2) | 18 (15.9) | 6 (11.3) | 1 (5.3) |
| No. of miscarriages (%) | 36 (27.9) | 31 (36.5) | 16 (32.6) | (9) (50.0) | 5 (83.3) | 1 (100.0) |
| No. of live births (%) | 93 (17.3) | 54 (11.6) | 33 (8.2) | 9 (7.9) | 1 (1.9) | 0 (0.0) |
| No. of newborns | 104 | 58 | 35 | 9 | 1 | 0 |