<abstract xmlns="http://www.w3.org/1999/xhtml"><p>The family of Bcl-2 proteins is one of the most responsible for apoptosis pathway, that is a critical process to the maintenance of tissue homeostasis. Bcl-2 is an essential apoptotic regulator belonging to a family of functionally and structurally related proteins known as the Bcl-2 family. Some members of this family act as anti-apoptotic regulators, whereas others act in pro-apoptotic function. The relationship between the pro and anti-apoptotic proteins can regulate whether cells begin the apoptosis or remain its life cycle. Increasing of Bcl-2 expression has been found in some hematologic diseases, such as Acute Myeloid Leukemia (AML) and their effects on responsiveness to anticancer therapy have been recently described. Thus, this review aims to discuss apoptosis and the role of the Bcl-2 family of proteins in chemoresistance when overexpressed in patients committed with Acute Myeloid Leukemia submitted to chemotherapy treatment.</p></abstract>

The family of Bcl-2 proteins is one of the most responsible for apoptosis pathway, that is a critical process to the maintenance of tissue homeostasis. Bcl-2 is an essential apoptotic regulator belonging to a family of functionally and structurally related proteins known as the Bcl-2 family. Some members of this family act as anti-apoptotic regulators, whereas others act in pro-apoptotic function. The relationship between the pro and anti-apoptotic proteins can regulate whether cells begin the apoptosis or remain its life cycle. Increasing of Bcl-2 expression has been found in some hematologic diseases, such as Acute Myeloid Leukemia (AML) and their effects on responsiveness to anticancer therapy have been recently described. Thus, this review aims to discuss apoptosis and the role of the Bcl-2 family of proteins in chemoresistance when overexpressed in patients committed with Acute Myeloid Leukemia submitted to chemotherapy treatment.

Bcl-2 Family Overexpression and Chemoresistance in Acute Myeloid Leukemia

Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science

Department of Immunology, Aggeu Magalhães Institute (IAM)

Experimental and Applied Biomedical Research (EABR)

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

{"article-title":"Bcl-2 Family Overexpression and Chemoresistance in Acute Myeloid Leukemia"}

The family of Bcl-2 proteins is one of the most responsible for apoptosis pathway, that is a critical process to the maintenance of tissue homeostasis. Bcl-2...

Bcl-2 Family Overexpression and Chemoresistance in Acute Myeloid Leukemia

Published Online: Feb 23, 2019

Page range: 299 - 309

Received: Aug 07, 2018

Accepted: Nov 25, 2018

DOI: https://doi.org/10.2478/sjecr-2018-0064

Keywords
Acute Myeloid Leukemia, Apoptosis, Bcl-2 family, Chemotherapy resistance

© 2018 Alex José de Melo Silva, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Bcl-2 Family Overexpression and Chemoresistance in Acute Myeloid Leukemia

Published Online: Feb 23, 2019

Page range: 299 - 309

Received: Aug 07, 2018

Accepted: Nov 25, 2018

DOI: https://doi.org/10.2478/sjecr-2018-0064

KeywordsAcute Myeloid Leukemia, Apoptosis, Bcl-2 family, Chemotherapy resistance

© 2018 Alex José de Melo Silva, published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
Acute Myeloid Leukemia, Apoptosis, Bcl-2 family, Chemotherapy resistance