Cite

1. Kaplan MM, Gershwin ME. Primary biliary cirrhosis. N Engl J Med. 2005; 353(12): 1261-1273.10.1056/NEJMra043898Search in Google Scholar

2. Bergasa NV. Pruritus and fatigue in primary biliary cirrhosis. Clin Liver Dis. 2003; 7: 879-900.10.1016/S1089-3261(03)00105-3Search in Google Scholar

3. Selmi C, Bowlus CL, Gershwin ME, Coppel RL. Primary biliary cirrhosis. Lancet. 2011; 377: 1600-1609.10.1016/S0140-6736(10)61965-4Search in Google Scholar

4. Gershwin ME, Mackay IR. The causes of primary biliary cirrhosis: Convenient and inconvenient truths. Hepatology. 2008; 47(2): 737-745.Search in Google Scholar

5. Hirschfield GM, Gershwin ME. The immunobiology and pathophysiology of primary biliary cirrhosis. Annu Rev Pathol. 2013; 8: 303-330.10.1146/annurev-pathol-020712-164014Search in Google Scholar

6. Walker JG, Doniach D, Roitt IM, Sherlock S. Serological tests in diagnosis of primary biliary cirrhosis. Lancet 1965; 1: 827-831.10.1016/S0140-6736(65)91372-3Search in Google Scholar

7. Fussey SP, Guest JR, James OF, Bassendine MF, Yeaman SJ. Identification and analysis of the major M2 autoantigens in primary biliary cirrhosis. Proc. Natl. Acad. Sci. USA 1988; 85: 8654-8658.10.1073/pnas.85.22.86542825183186751Search in Google Scholar

8. Moteki S, Leung PS, Dickson ER, et al. Epitope mapping and reactivity of autoantibodies to the E2 component of 2-oxoglutarate dehydrogenase complex in primary biliary cirrhosis using recombinant 2-oxoglutarate dehydrogenase complex. Hepatology. 1996; 23(3): 436-444.10.1002/hep.5102303078617422Search in Google Scholar

9. Miller FW, Alfredsson L, Costenbader KH, et al. Epidemiology of environmental exposures and human autoimmune diseases: findings from a National Institute of Environmental Health Sciences Expert Panel Workshop. J Autoimmun. 2012; 39(4): 259-271.10.1016/j.jaut.2012.05.002349681222739348Search in Google Scholar

10. Selmi C, Leung PS, Sherr DH, Diaz et al. Mechanisms of environmental influence on human autoimmunity: a National Institute of Environmental Health Sciences expert panel workshop. J Autoimmun. 2012; 39(4): 272-284.10.1016/j.jaut.2012.05.00722749494Search in Google Scholar

11. Selmi C, Balkwill DL, Invernizzi P, et al. Patients with primary biliary cirrhosis react against a ubiquitous xenobiotic-metabolizing bacterium. Hepatology. 2003; 38(5): 1250-1257.10.1053/jhep.2003.5044614578864Search in Google Scholar

12. Mattner J, Savage PB, Leung P, et al. Liver autoimmunity triggered by microbial activation of natural killer T cells. Cell Host Microbe. 2008; 3(5): 304-315.10.1016/j.chom.2008.03.009245352018474357Search in Google Scholar

13. Rieger R, Leung PS, Jeddeloh MR, et al. Identification of 2-nonynoic acid, a cosmetic component, as a potential trigger of primary biliary cirrhosis. J Autoimmun. 2006; 27(1): 7-16.10.1016/j.jaut.2006.06.00216876981Search in Google Scholar

14. Wakabayashi K, Lian ZX, Leung PS, et al. Loss of tolerance in C57BL/6 mice to the autoantigen E2 subunit of pyruvate dehydrogenase by a xenobiotic with ensuing biliary ductular disease. Hepatology. 2008; 48(2): 531-540.10.1002/hep.22390375301118563844Search in Google Scholar

15. Wakabayashi K, Yoshida K, Leung PS, et al. Induction of autoimmune cholangitis in non-obese diabetic (NOD).1101 mice following a chemical xenobiotic immunization. Clin Exp Immunol. 2009; 155(3): 577-586.10.1111/j.1365-2249.2008.03837.x266953519094117Search in Google Scholar

16. Ambrosini YM, Yang GX, Zhang W, et al. The multi-hit hypothesis of primary biliary cirrhosis: polyinosinicpolycytidylic acid (poly I:C) and murine autoimmune cholangitis. Clin Exp Immunol. 2011; 166(1): 110-120.10.1111/j.1365-2249.2011.04453.x319392621910728Search in Google Scholar

17. Wu SJ, Yang YH, Tsuneyama K, et al. Innate immunity and primary biliary cirrhosis: activated invariant natural killer T cells exacerbate murine autoimmune cholangitis and fibrosis. Hepatology. 2011; 53(3): 915-925.10.1002/hep.24113307633421374662Search in Google Scholar

18. Gershwin ME, Ansari AA, Mackay IR, et al. Primary biliary cirrhosis: an orchestrated immune response against epithelial cells. Immunol Rev. 2000; 174: 210-225.10.1034/j.1600-0528.2002.017402.x10807518Search in Google Scholar

19. Kita H, Matsumura S, He XS, et al. Quantitative and functional analysis of PDC-E2-specific autoreactive cytotoxic T lymphocytes in primary biliary cirrhosis. J Clin Invest. 2002; 109(9): 1231-1240.10.1172/JCI0214698Search in Google Scholar

20. Chuang YH, Lan RY, Gershwin ME. The immunopathology of human biliary cell epithelium. Semin Immunopathol. 2009; 31(3): 323-331.10.1007/s00281-009-0172-519533127Search in Google Scholar

21. Kimura Y, Leung PS, Kenny TP, et al. Differential expression of intestinal trefoil factor in biliary epithelial cells of primary biliary cirrhosis. Hepatology. 2002; 36(5): 1227-1235.10.1053/jhep.2002.3615712395334Search in Google Scholar

22. Lleo A, Invernizzi P, Mackay IR, Prince H, Zhong RQ, Gershwin ME. Etiopathogenesis of primary biliary cirrhosis. World J Gastroenterol. 2008; 14(21): 3328-3337.10.3748/wjg.14.3328271658718528930Search in Google Scholar

23. Odin JA, Huebert RC, Casciola-Rosen L, LaRusso NF, Rosen A. Bcl-2-dependent oxidation of pyruvate dehydrogenase- E2, a primary biliary cirrhosis autoantigen, during apoptosis. J Clin Invest. 2001; 108(2): 223-232.10.1172/JCI200110716Search in Google Scholar

24. Lleo A, Selmi C, Invernizzi P, et al. Apotopes and the biliary specificity of primary biliary cirrhosis. Hepatology. 2009; 49(3): 871-879.10.1002/hep.22736266592519185000Search in Google Scholar

25. Lleo A, Bowlus CL, Yang GX, et al. Biliary apotopes and anti-mitochondrial antibodies activate innate immune responses in primary biliary cirrhosis. Hepatology. 2010; 52(3): 987-998.10.1002/hep.23783293280920568301Search in Google Scholar

26. Van de Water J, Gerson LB, Ferrell LD, et al. Immunohistochemical evidence of disease recurrence after liver transplantation for primary biliary cirrhosis. Hepatology. 1996; 24(5): 1079-1084.10.1002/hep.5102405178903379Search in Google Scholar

27. Van de Water J, Turchany J, Leung PS, et al. Molecular mimicry in primary biliary cirrhosis. Evidence for biliary epithelial expression of a molecule cross-reactive with pyruvate dehydrogenase complex-E2. J Clin Invest. 1993; 91(6): 2653-2664.10.1172/JCI1165044433298514873Search in Google Scholar

28. Tsuneyama K, Van de Water J, Leung PS, et al. Abnormal expression of the E2 component of the pyruvate dehydrogenase complex on the luminal surface of biliary epithelium occurs before major histocompatibility complex class II and BB1/B7 expression. Hepatology. 1995; 21(4): 1031-1037.Search in Google Scholar

29. Matsumura S, Van De Water J, Leung P, et al. Caspase induction by IgA antimitochondrial antibody: IgA-mediated biliary injury in primary biliary cirrhosis. Hepatology. 2004; 39(5): 1415-1422.10.1002/hep.2017515122771Search in Google Scholar

30. Kita H, Naidenko OV, Kronenberg M, et al. Quantitation and phenotypic analysis of natural killer T cells in primary biliary cirrhosis using a human CD1d tetramer. Gastroenterology. 2002; 123(4): 1031-1043.10.1053/gast.2002.3602012360465Search in Google Scholar

31. Kita H, Lian ZX, Van de Water J, et al. Identification of HLA-A2-restricted CD8(+) cytotoxic T cell responses in primary biliary cirrhosis: T cell activation is augmented by immune complexes cross-presented by dendritic cells. J Exp Med. 2002; 195(1): 113-123.10.1084/jem.20010956219601211781370Search in Google Scholar

32. Shimoda S, Miyakawa H, Nakamura M, et al. CD4 Tcell autoreactivity to the mitochondrial autoantigen PDC-E2 in AMA-negative primary biliary cirrhosis. J Autoimmun. 2008; 31(2): 110-115.10.1016/j.jaut.2008.05.00318644699Search in Google Scholar

33. Van de Water J, Ansari A, Prindiville T, et al. Heterogeneity of autoreactive T cell clones specific for the E2 component of the pyruvate dehydrogenase complex in primary biliary cirrhosis. J Exp Med. 1995; 181(2): 723-733.10.1084/jem.181.2.72321918877836925Search in Google Scholar

34. Oo YH, Weston CJ, Lalor PF, et al. Distinct roles for CCR4 and CXCR3 in the recruitment and positioning of regulatory T cells in the inflamed human liver. J Immunol. 2010; 184(6): 2886-2898.10.4049/jimmunol.090121620164417Search in Google Scholar

35. Lan RY, Cheng C, Lian ZX, et al. Liver-targeted and peripheral blood alterations of regulatory T cells in primary biliary cirrhosis. Hepatology. 2006; 43(4): 729-737. 10.1002/hep.2112316557534Search in Google Scholar

36. Lan RY, Salunga TL, Tsuneyama K, et al. Hepatic IL-17 responses in human and murine primary biliary cirrhosis. J Autoimmun. 2009; 32(1): 43-51.10.1016/j.jaut.2008.11.001322505319101114Search in Google Scholar

37. Harada K, Isse K, Nakanuma Y. Interferon gamma accelerates NF-kappaB activation of biliary epithelial cells induced by Toll-like receptor and ligand interaction. J Clin Pathol. 2006; 59(2): 184-190.10.1136/jcp.2004.023507186032416443736Search in Google Scholar

38. Shimoda S, Harada K, Niiro H, et al. CX3CL1 (fractalkine): a signpost for biliary inflammation in primary biliary cirrhosis. Hepatology. 2010; 51(2): 567-575.10.1002/hep.23318291195919908209Search in Google Scholar

39. Chuang YH, Lian ZX, Yang GX, et al. Natural killer T cells exacerbate liver injury in a transforming growth factor beta receptor II dominant-negative mouse model of primary biliary cirrhosis. Hepatology. 2008; 47(2): 571-580.10.1002/hep.2205218098320Search in Google Scholar

40. Krams SM, Dorshkind K, Gershwin ME. Generation of biliary lesions after transfer of human lymphocytes into severe combined immunodeficient (SCID) mice. J Exp Med. 1989; 170(6): 1919-1930.10.1084/jem.170.6.191921895382584930Search in Google Scholar

41. Irie J, Wu Y, Wicker LS, et al. NOD.c3c4 congenic mice develop autoimmune biliary disease that serologically and pathogenetically models human primary biliary cirrhosis. J Exp Med. 2006; 203(5): 1209-1219.10.1084/jem.20051911212120416636131Search in Google Scholar

42. Oertelt S, Lian ZX, Cheng CM, et al. Anti-mitochondrial antibodies and primary biliary cirrhosis in TGFbeta receptor II dominant-negative mice. J Immunol. 2006; 177(3): 1655-1660.10.4049/jimmunol.177.3.165516849474Search in Google Scholar

43. Wakabayashi K, Lian ZX, Moritoki Y, et al. IL-2 receptor alpha(-/-) mice and the development of primary biliary cirrhosis. Hepatology. 2006; 44(5): 1240-1249.10.1002/hep.2138517058261Search in Google Scholar

44. Hsu W, Zhang W, Tsuneyama K, et al. Differential mechanisms in the pathogenesis of autoimmune cholangitis versus inflammatory bowel disease in interleukin-2Ralpha(-/-) mice. Hepatology. 2009; 49(1): 133-140.10.1002/hep.22591261445119065673Search in Google Scholar

45. Amano K, Leung PS, Rieger R, et al. Chemical xenobiotics and mitochondrial autoantigens in primary biliary cirrhosis: identification of antibodies against a common environmental, cosmetic, and food additive, 2-octynoic acid. J Immunol. 2005; 174(9): 5874-5883.10.4049/jimmunol.174.9.587415845458Search in Google Scholar

46. Naiyanetr P, Butler JD, Meng L, et al. Electrophilemodified lipoic derivatives of PDC-E2 elicits anti-mitochondrial antibody reactivity. J Autoimmun. 2011; 37(3): 209-216.10.1016/j.jaut.2011.06.001320614121763105Search in Google Scholar

47. Rieger R, Leung PS, Jeddeloh MR, et al. Identification of 2-nonynoic acid, a cosmetic component, as a potential trigger of primary biliary cirrhosis. J Autoimmun. 2006; 27(1): 7-16.10.1016/j.jaut.2006.06.00216876981Search in Google Scholar

48. Leung PS, Park O, Tsuneyama K, et al. Induction of primary biliary cirrhosis in guinea pigs following chemical xenobiotic immunization. J Immunol. 2007; 179(4): 2651-2657.10.4049/jimmunol.179.4.265117675529Search in Google Scholar

49. Leung PS, Quan C, Park O, et al. Immunization with a xenobiotic 6-bromohexanoate bovine serum albumin conjugate induces antimitochondrial antibodies. J Immunol. 2003; 170(10): 5326-5332. 10.4049/jimmunol.170.10.532612734383Search in Google Scholar

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