Late arrhythmia in patients with repaired tetralogy of Fallot: who is at risk?

[1] Hoffman JI, Kaplan S. The incidence of congenital heart disease. J Am Coll Cardiol 2002;39:1890–900.10.1016/S0735-1097(02)01886-7Search in Google Scholar

[2] Bacha EA, Scheule AM, Zurakowski D, Erickson LC, Hung J, Lang P, et al. Long-term results after early primary repair of tetralogy of Fallot. J Thorac Cardiovasc Surg 2001;122:154–61.10.1067/mtc.2001.115156Search in Google Scholar

[3] Parry AJ, McElhinney DB, Kung GC, Reddy VM, Brook MM, Hanley FL. Elective primary repair of acyanotic tetralogy of Fallot in early infancy: overall outcome and impact on the pulmonary valve. J Am Coll Cardiol 2000;36:2279–83.10.1016/S0735-1097(00)00989-XSearch in Google Scholar

[4] Murphy JG, Gersh BJ, Mair DD, Fuster V, McGoon MD, Ilstrup DM, et al. Long-term outcome in patients undergoing surgical repair of tetralogy of Fallot. N Engl J Med 1993;329:593–9.10.1056/NEJM199308263290901Search in Google Scholar

[5] Chiu S-N, Wang J-K, Chen H-C, Lin M-T, Wu E-T, Chen C-A, et al. Long-term survival and unnatural deaths of patients with repaired tetralogy of Fallot in an Asian cohort. Circ Cardiovasc Qual Outcomes 2012;5:120–5.10.1161/CIRCOUTCOMES.111.963603Search in Google Scholar

[6] Nollert G, Fischlein T, Bouterwek S, Böhmer C, Klinner W, Reichart B. Long-term survival in patients with repair of tetralogy of Fallot: 36-year follow-up of 490 survivors of the first year after surgical repair. J Am Coll Cardiol 1997;30:1374–83.10.1016/S0735-1097(97)00318-5Search in Google Scholar

[7] Nieminen HP, Jokinen EV, Sairanen HI. Causes of late deaths after pediatric cardiac surgery: a population-based study. J Am Coll Cardiol 2007;50:1263–71.10.1016/j.jacc.2007.05.040Search in Google Scholar

[8] Garson A Jr, Randall DC, Gillette PC, Smith RT, Moak JP, McVey P, et al. Prevention of sudden death after repair of tetralogy of Fallot: Treatment of ventricular arrhythmias. J Am Coll Cardiol 1985;6:221–7.10.1016/S0735-1097(85)80279-5Search in Google Scholar

[9] Khairy P, Aboulhosn J, Gurvitz MZ, Opotowsky AR, Mongeon F-P, Kay J, et al. Arrhythmia burden in adults with surgically repaired tetralogy of Fallot: a multi-institutional study. Circulation 2010;122:868–75.10.1161/CIRCULATIONAHA.109.928481Search in Google Scholar

[10] Gatzoulis MA, Balaji S, Webber S, Siu S, Hokanson J, Poile C, et al. Risk factors for arrhythmia and sudden cardiac death late after repair of tetralogy of Fallot: a multicentre study. Lancet 2000;356:975–81.10.1016/S0140-6736(00)02714-8Search in Google Scholar

[11] Harrison DA, Harris L, Siu SC, MacLoghlin CJ, Connelly MS, Webb GD, et al. Sustained ventricular tachycardia in adult patients late after repair of tetralogy of Fallot. J Am Coll Cardiol 1997;30:1368–73.10.1016/S0735-1097(97)00316-1Search in Google Scholar

[12] Misaki T, Tsubota M, Watanabe G, Watanabe Y, Matumoto Y, Ishida K, et al. Surgical treatment of ventricular tachycardia after surgical repair of tetralogy of Fallot. Relation between intraoperative mapping and histological findings. Circulation 1994;90:264–71.10.1161/01.CIR.90.1.264Search in Google Scholar

[13] Dietl CA, Cazzaniga ME, Dubner SJ, Pérez-Baliño NA, Torres AR, Favaloro RG. Life-threatening arrhythmias and RV dysfunction after surgical repair of tetralogy of Fallot. Comparison between transventricular and transatrial approaches. Circulation 1994;90:II7–12.Search in Google Scholar

[14] Therrien J, Siu SC, Harris L, Dore A, Niwa K, Janousek J, et al. Impact of pulmonary valve replacement on arrhythmia propensity late after repair of tetralogy of Fallot. Circulation 2001;103:2489–94.10.1161/01.CIR.103.20.2489Search in Google Scholar

[15] Oechslin EN, Harrison DA, Connelly MS, Webb GD, Siu SC. Mode of death in adults with congenital heart disease. Am J Cardiol 2000;86:1111–6.10.1016/S0002-9149(00)01169-3Search in Google Scholar

[16] James FW, Kaplan S, Chou TC. Unexpected cardiac arrest in patients after surgical correction of tetralogy of Fallot. Circulation 1975;52:691–5.10.1161/01.CIR.52.4.691Search in Google Scholar

[17] Gillette PC, Yeoman MA, Mullins CE, McNamara DG. Sudden death after repair of tetralogy of Fallot. Electrocardiographic and electrophysiologic abnormalities. Circulation 1977;56:566–71.10.1161/01.CIR.56.4.566Search in Google Scholar

[18] Koyak Z, Harris L, de Groot JR, Silversides CK, Oechslin EN, Bouma BJ, et al. Sudden cardiac death in adult congenital heart disease. Circulation 2012;126:1944–54.10.1161/CIRCULATIONAHA.112.104786Search in Google Scholar

[19] Kremers MS, Wells PJ, Black WH, Solodyna MA. Entrainment of ventricular tachycardia in postoperative tetralogy of Fallot. Pacing Clin Electrophysiol 1988;11:1310–4.10.1111/j.1540-8159.1988.tb03993.xSearch in Google Scholar

[20] Horowitz LN, Vetter VL, Harken AH, Josephson ME. Electrophysiologic characteristics of sustained ventricular tachycardia occurring after repair of tetralogy of Fallot. Am J Cardiol 1980;46:446–52.10.1016/0002-9149(80)90014-4Search in Google Scholar

[21] Kugler JD, Pinsky WW, Cheatham JP, Hofschire PJ, Mooring PK, Fleming WH. Sustained ventricular tachycardia after repair of tetralogy of Fallot: New electrophysiologic findings. Am J Cardiol 1983;51:1137–43.10.1016/0002-9149(83)90359-4Search in Google Scholar

[22] Downar E, Harris L, Kimber S, Mickleborough L, Williams W, Sevaptsidis E, et al. Ventricular tachycardia after surgical repair of tetralogy of Fallot: results of intraoperative mapping studies. J Am Coll Cardiol 1992;20:648–55.10.1016/0735-1097(92)90020-NSearch in Google Scholar

[23] Khairy P, Landzberg MJ, Gatzoulis MA, Lucron H, Lambert J, Marçon F, et al. Value of programmed ventricular stimulation after tetralogy of Fallot repair: a multicenter study. Circulation 2004;109:1994–2000.10.1161/01.CIR.0000126495.11040.BDSearch in Google Scholar

[24] Khairy P. Programmed ventricular stimulation for risk stratification in patients with tetralogy of Fallot: a Bayesian perspective. Nat Clin Pract Cardiovasc Med 2007;4:292–3.10.1038/ncpcardio0882Search in Google Scholar

[25] Roos-Hesselink J, Perlroth MG, McGhie J, Spitaels S. Atrial arrhythmias in adults after repair of tetralogy of Fallot: Correlations with clinical, exercise, and echocardiographic findings. Circulation 1995;91:2214–9.10.1161/01.CIR.91.8.2214Search in Google Scholar

[26] Valente AM, Gauvreau K, Assenza GE, Babu-Narayan SV, Schreier J, Gatzoulis MA, et al. Contemporary predictors of death and sustained ventricular tachycardia in patients with repaired tetralogy of Fallot enrolled in the INDICATOR cohort. Heart 2014;100:247–53.10.1136/heartjnl-2013-304958Search in Google Scholar

[27] Rosianu S, Paprika D, Osztheimer I, Temesvari A, Szili-Torok T. Echocardiographic evaluation of patients with undocumented arrhythmias occurring in adults late after repair of tetralogy of Fallot. Eur J Echocardiogr 2009;10:139–43.10.1093/ejechocard/jen199Search in Google Scholar

[28] Karl TR, Sano S, Pornviliwan S, Mee RB. Tetralogy of Fallot: favorable outcome of nonneonatal transatrial, transpulmonary repair. Ann Thorac Surg 1992;54:903–7.10.1016/0003-4975(92)90646-LSearch in Google Scholar

[29] Al Habib HF, Jacobs JP, Mavroudis C, Tchervenkov CI, O’Brien SM, Mohammadi S, et al. Contemporary patterns of management of tetralogy of Fallot: data from the Society of Thoracic Surgeons Database. Ann Thorac Surg 2010;90:813–20.10.1016/j.athoracsur.2010.03.110Search in Google Scholar

[30] Kim H, Sung SC, Kim SH, Chang YH, Lee HD, Park JA, et al. Early and late outcomes of total repair of tetralogy of Fallot: risk factors for late right ventricular dilatation. Interact Cardiovasc Thorac Surg 2013;17:956–62.10.1093/icvts/ivt361Search in Google Scholar

[31] Reddy VM, Liddicoat JR, McElhinney DB, Brook MM, Stanger P, Hanley FL. Routine primary repair of tetralogy of Fallot in neonates and infants less than three months of age. Ann Thorac Surg 1995;60:S592–6.10.1016/0003-4975(95)00732-6Search in Google Scholar

[32] Stellin G, Milanesi O, Rubino M, Michielon G, Bianco R, Moreolo GS, et al. Repair of tetralogy of Fallot in the first six months of life: transatrial versus transventricular approach. Ann Thorac Surg 1995;60:S588–91.10.1016/0003-4975(95)00849-7Search in Google Scholar

[33] Fraser CD Jr, McKenzie ED, Cooley DA. Tetralogy of Fallot: surgical management individualized to the patient. Ann Thorac Surg 2001;71:1556–63.10.1016/S0003-4975(01)02475-4Search in Google Scholar

[34] Stewart RD, Backer CL, Young L, Mavroudis C. Tetralogy of Fallot: results of a pulmonary valve-sparing strategy. Ann Thorac Surg 2005;80:1431–9.10.1016/j.athoracsur.2005.04.016Search in Google Scholar

[35] Niu MC, Morris SA, Morales DL, Fraser CD Jr, Kim JJ. Low incidence of arrhythmias in the right ventricular infundibulum sparing approach to tetralogy of Fallot repair. Pediatr Cardiol 2014;35:261–9.10.1007/s00246-013-0767-4Search in Google Scholar

[36] Mahle WT, McBride MG, Paridon SM. Exercise performance in tetralogy of Fallot: the impact of primary complete repair in infancy. Pediatr Cardiol 2002;23:224–9.10.1007/s00246-001-0054-7Search in Google Scholar

[37] Tamesberger MI, Lechner E, Mair R, Hofer A, Sames-Dolzer E, Tulzer G. Early primary repair of tetralogy of Fallot in neonates and infants less than four months of age. Ann Thorac Surg 2008;86:1928–35.10.1016/j.athoracsur.2008.07.019Search in Google Scholar

[38] Vohra HA, Adamson L, Haw MP. Is early primary repair for correction of tetralogy of Fallot comparable to surgery after 6 months of age? Interact Cardiovasc Thorac Surg 2008;7:698–701.10.1510/icvts.2008.180083Search in Google Scholar

[39] Gladman G, Mccrindle BW, Williams WG, Freedom RM, Benson LN. The modified Blalock-Taussig shunt: clinical impact and morbidity in Fallot’s tetralogy in the current era. J Thorac Cardiovasc Surg 1997;114:25–30.10.1016/S0022-5223(97)70113-2Search in Google Scholar

[40] Oosterhof T, van Straten A, Vliegen HW, Meijboom FJ, van Dijk AP, Spijkerboer AM, et al. Preoperative thresholds for pulmonary valve replacement in patients with corrected tetralogy of Fallot using cardiovascular magnetic resonance. Circulation 2007;116:545–51.10.1161/CIRCULATIONAHA.106.65966417620511Search in Google Scholar

[41] Abd El Rahman MY, Abdul-Khaliq H, Vogel M, Alexi-Meskishvili V, Gutberlet M, Lange PE. Relation between right ventricular enlargement, QRS duration, and right ventricular function in patients with tetralogy of Fallot and pulmonary regurgitation after surgical repair. Heart 2000;84:416–20.10.1136/heart.84.4.416172945310995413Search in Google Scholar

[42] Rebergen SA, Chin JG, Ottenkamp J, van der Wall EE, de Roos A. Pulmonary regurgitation in the late postoperative follow-up of tetralogy of Fallot. Volumetric quantitation by nuclear magnetic resonance velocity mapping. Circulation 1993;88:2257–66.10.1161/01.CIR.88.5.22578222120Search in Google Scholar

[43] Meagher SO, Ganigara M, Tanous DJ, Celermajer DS, Puranik R. Progress of right ventricular dilatation in adults with repaired tetralogy of Fallot and free pulmonary regurgitation. Int J Cardiol Heart Vessels 2014;3:28–31.10.1016/j.ijchv.2014.02.003580127029450166Search in Google Scholar

[44] Therrien J, Provost Y, Merchant N, Williams W, Colman J, Webb G. Optimal timing for pulmonary valve replacement in adults after tetralogy of Fallot repair. Am J Cardiol 2005;95:779–82.10.1016/j.amjcard.2004.11.03715757612Search in Google Scholar

[45] Buechel ER, Dave HH, Kellenberger CJ, Dodge-Khatami A, Pretre R, Berger F, et al. Remodelling of the right ventricle after early pulmonary valve replacement in children with repaired tetralogy of Fallot: assessment by cardiovascular magnetic resonance. Eur Heart J 2005;26:2721–7.10.1093/eurheartj/ehi58116214832Search in Google Scholar

[46] Geva T, Sandweiss BM, Gauvreau K, Lock JE, Powell AJ. Factors associated with impaired clinical status in long-term survivors of tetralogy of Fallot repair evaluated by magnetic resonance imaging. J Am Coll Cardiol 2004;43:1068–74.10.1016/j.jacc.2003.10.04515028368Search in Google Scholar

[47] Wald RM, Redington AN, Pereira A, Provost YL, Paul NS, Oechslin EN, et al. Refining the assessment of pulmonary regurgitation in adults after tetralogy of Fallot repair: should we be measuring regurgitant fraction or regurgitant volume? Eur Heart J 2009;30:356–61.10.1093/eurheartj/ehn59519164336Search in Google Scholar

[48] Mooij CF, de Wit CJ, Graham DA, Powell AJ, Geva T. Reproducibility of MRI measurements of right ventricular size and function in patients with normal and dilated ventricles. J Magn Reson Imaging 2008;28:67–73.10.1002/jmri.21407253368818581357Search in Google Scholar

[49] Knauth AL, Gauvreau K, Powell AJ, Landzberg MJ, Walsh EP, Lock JE, et al. Ventricular size and function assessed by cardiac MRI predict major adverse clinical outcomes late after tetralogy of Fallot repair. Heart 2008;94:211–6.10.1136/hrt.2006.10474517135219Search in Google Scholar

[50] Van Huysduynen BH, van Straten A, Swenne CA, Maan AC, van Eck HJ, Schalij MJ, et al. Reduction of QRS duration after pulmonary valve replacement in adult Fallot patients is related to reduction of right ventricular volume. Eur Heart J 2005;26:928–32.10.1093/eurheartj/ehi14015716288Search in Google Scholar

[51] Vliegen HW, van Straten A, de Roos A, Roest AA, Schoof PH, Zwinderman AH, et al. Magnetic resonance imaging to assess the hemodynamic effects of pulmonary valve replacement in adults late after repair of tetralogy of Fallot. Circulation 2002;106:1703–7.10.1161/01.CIR.0000030995.59403.F812270866Search in Google Scholar

[52] Van Straten A, Vliegen HW, Hazekamp MG, Bax JJ, Schoof PH, Ottenkamp J, et al. Right ventricular function after pulmonary valve replacement in patients with tetralogy of Fallot. Radiology 2004;233:824–9.10.1148/radiol.2333030804Search in Google Scholar

[53] Geva T, Gauvreau K, Powell AJ, Cecchin F, Rhodes J, Geva J, et al. Randomized trial of pulmonary valve replacement with and without right ventricular remodeling surgery. Circulation 2010;122:S201–8.10.1161/CIRCULATIONAHA.110.951178Search in Google Scholar

[54] Tzemos N, Harris L, Carasso S, Subira LD, Greutmann M, Provost Y, et al. Adverse left ventricular mechanics in adults with repaired tetralogy of Fallot. Am J Cardiol 2009;103:420–5.10.1016/j.amjcard.2008.09.101Search in Google Scholar

[55] Horowitz LN, Simson MB, Spear JF, Josephson ME, Moore EN, Alexander JA, et al. The mechanism of apparent right bundle branch block after transatrial repair of tetralogy of Fallot. Circulation 1979;59:1241–52.10.1161/01.CIR.59.6.1241Search in Google Scholar

[56] Khairy P, Marelli AJ. Clinical use of electrocardiography in adults with congenital heart disease. Circulation 2007;116:2734–46.10.1161/CIRCULATIONAHA.107.691568Search in Google Scholar

[57] Gatzoulis MA, Till JA, Somerville J, Redington AN. Mechanoelectrical interaction in tetralogy of Fallot: QRS prolongation relates to right ventricular size and predicts malignant ventricular arrhythmias and sudden death. Circulation 1995;92:231–7.10.1161/01.CIR.92.2.231Search in Google Scholar

[58] Uebing A, Gibson DG, Babu-Narayan SV, Diller GP, Dimopoulos K, Goktekin O, et al. Right ventricular mechanics and QRS duration in patients with repaired tetralogy of Fallot: implications of infundibular disease. Circulation 2007;116:1532–9.10.1161/CIRCULATIONAHA.107.688770Search in Google Scholar

[59] Babu-Narayan SV, Kilner PJ, Li W, Moon JC, Goktekin O, Davlouros PA, et al. Ventricular fibrosis suggested by cardiovascular magnetic resonance in adults with repaired tetralogy of Fallot and its relationship to adverse markers of clinical outcome. Circulation 2006;113:405–13.10.1161/CIRCULATIONAHA.105.548727Search in Google Scholar

[60] Dubin AM, Feinstein JA, Reddy VM, Hanley FL, Van Hare GF, Rosenthal DN. Electrical resynchronization: a novel therapy for the failing right ventricle. Circulation 2003;107:2287–9.10.1161/01.CIR.0000070930.33499.9FSearch in Google Scholar

[61] Ghai A, Silversides C, Harris L, Webb GD, Siu SC, Therrien J. Left ventricular dysfunction is a risk factor for sudden cardiac death in adults late after repair of tetralogy of Fallot. J Am Coll Cardiol 2002;40:1675–80.10.1016/S0735-1097(02)02344-6Search in Google Scholar

[62] Ortega M, Triedman JK, Geva T, Harrild DM. Relation of left ventricular dyssynchrony measured by cardiac magnetic resonance tissue tracking in repaired tetralogy of Fallot to ventricular tachycardia and death. Am J Cardiol 2011;107:1535–40.10.1016/j.amjcard.2011.01.032Search in Google Scholar

[63] Davlouros PA, Kilner PJ, Hornung TS, Li W, Francis JM, Moon JC, et al. Right ventricular function in adults with repaired tetralogy of Fallot assessed with cardiovascular magnetic resonance imaging: Detrimental role of right ventricular outflow aneurysms or akinesia and adverse right-to-left ventricular interaction. J Am Coll Cardiol 2002;40:2044–52.10.1016/S0735-1097(02)02566-4Search in Google Scholar

[64] Bonello B, Kempny A, Uebing A, Li W, Kilner PJ, Diller GP, et al. Right atrial area and right ventricular outflow tract akinetic length predict sustained tachyarrhythmia in repaired tetralogy of Fallot. Int J Cardiol 2013;168:3280–6.10.1016/j.ijcard.2013.04.048381962223643427Search in Google Scholar

[65] Rodriguez FH, Moodie DS, Neeland M, Adams GJ, Snyder CS. Identifying arrhythmias in adults with congenital heart disease by 24-h ambulatory electrocardiography. Pediatr Cardiol 2012;33:591–5.10.1007/s00246-012-0183-122318853Search in Google Scholar

[66] Czosek RJ, Anderson J, Khoury PR, Knilans TK, Spar DS, Marino BS. Utility of ambulatory monitoring in patients with congenital heart disease. Am J Cardiol 2013;111:723–30.10.1016/j.amjcard.2012.11.02123246250Search in Google Scholar

[67] Khairy P, Van Hare GF, Balaji S, Berul CI, Cecchin F, Cohen MI, et al. PACES/HRS Expert Consensus Statement on the recognition and management of arrhythmias in adult congenital heart disease: Developed in partnership between the Pediatric and Congenital Electrophysiology Society (PACES) and the Heart Rhythm Society (HRS). Heart Rhythm 2014;11:e102–65.10.1016/j.hrthm.2014.05.00924814377Search in Google Scholar

[68] Khairy P, Harris L, Landzberg MJ, Viswanathan S, Barlow A, Gatzoulis MA, et al. Implantable cardioverter-defibrillators in tetralogy of Fallot. Circulation 2008;117:363–70.10.1161/CIRCULATIONAHA.107.72637218172030Search in Google Scholar

[69] Yap SC, Roos-Hesselink JW, Hoendermis ES, Budts W, Vliegen HW, Mulder BJ, et al. Outcome of implantable cardioverter defibrillators in adults with congenital heart disease: a multi-centre study. Eur Heart J 2007;28:1854–61.10.1093/eurheartj/ehl30617030523Search in Google Scholar

[70] Dore A, Santagata P, Dubuc M, Ee L. Implantable cardioverter defibrillators in adults with congenital heart disease: A single center experience. Pacing Clin Electrophysiol 2004;27:47–51.10.1111/j.1540-8159.2004.00384.x14720154Search in Google Scholar

[71] Koyak Z, de Groot JR, Van Gelder IC, Bouma BJ, van Dessel PF, Budts W, et al. Implantable cardioverter defibrillator therapy in adults with congenital heart disease: who is at risk of shocks? Circ Arrhythm Electrophysiol 2012;5:101–10.10.1161/CIRCEP.111.96675422095638Search in Google Scholar

[72] Friedmann E, Thomas SA, Inguito P, Kao CW, Metcalf M, Kelley FJ, et al. Quality of life and psychological status of patients with implantable cardioverter defibrillators. J Interv Card Electrophysiol 2006;17:65–72.10.1007/s10840-006-9053-117235681Search in Google Scholar

[73] Witte KK, Pepper CB, Cowan JC, Thomson JD, English KM, Blackburn ME. Implantable cardioverter–defibrillator therapy in adult patients with tetralogy of Fallot. Europace 2008;10:926–30.10.1093/europace/eun10818442962Search in Google Scholar

[74] Zeppenfeld K, Schalij MJ, Bartelings MM, Tedrow UB, Koplan BA, Soejima K, et al. Catheter ablation of ventricular tachycardia after repair of congenital heart disease: electroanatomic identification of the critical right ventricular isthmus. Circulation 2007;116:2241–52.10.1161/CIRCULATIONAHA.107.72355117967973Search in Google Scholar

[75] Morwood JG, Triedman JK, Berul CI, Khairy P, Alexander ME, Cecchin F, et al. Radiofrequency catheter ablation of ventricular tachycardia in children and young adults with congenital heart disease. HeartRhythm 2004;1:301–8.10.1016/j.hrthm.2004.05.00915851174Search in Google Scholar

[76] Kriebel T, Saul JP, Schneider H, Sigler M, Paul T. Noncontact mapping and radiofrequency catheter ablation of fast and hemodynamically unstable ventricular tachycardia after surgical repair of tetralogy of Fallot. J Am Coll Cardiol 2007;50:2162–8.10.1016/j.jacc.2007.07.07418036455Search in Google Scholar

[77] Mah DY, Alexander ME, Cecchin F, Walsh EP, Triedman JK. The electroanatomic mechanisms of atrial tachycardia in patients with tetralogy of Fallot and double outlet right ventricle. J Cardiovasc Electrophysiol 2011;22:1013–7.10.1111/j.1540-8167.2011.02062.x21539636Search in Google Scholar

[78] Triedman JK, DeLucca JM, Alexander ME, Berul CI, Cecchin F, Walsh EP. Prospective trial of electroanatomically guided, irrigated catheter ablation of atrial tachycardia in patients with congenital heart disease. HeartRhythm 2005;2:700–5.10.1016/j.hrthm.2005.03.01715992724Search in Google Scholar

[79] Opic P, Yap SC, Van Kranenburg M, Van Dijk AP, Budts W, Vliegen HW, et al. Atrial-based pacing has no benefit over ventricular pacing in preventing atrial arrhythmias in adults with congenital heart disease. Europace 2013;15:1757–62.10.1093/europace/eut21323851513Search in Google Scholar

[80] Connolly SJ, Dorian P, Roberts RS, Gent M, Bailin S, Fain ES, et al. Comparison of beta-blockers, amiodarone plus beta-blockers, or sotalol for prevention of shocks from implantable cardioverter defibrillators: the OPTIC Study: a randomized trial. JAMA 2006;295:165–71.10.1001/jama.295.2.16516403928Search in Google Scholar