<abstract xmlns="http://www.w3.org/1999/xhtml">Background: Oxidative damage is of great importance for patients with breast cancer. Thus, studies were performed to identify the relationship between breast cancer and oxidative stress biomarkers.Objectives: In this study, our aim was to find out the oxidative and antioxidant status, serum thiol-disulphide levels in subjects with breast cancer.Methods: This study was conducted between March and June 2018 with 82 control subjects (aged between 32-67 years) and 127 breast cancer patients (aged between 27-66 years) (p=0.058) in Selcuk University Faculty of Medicine, Konya, Turkey. Serum myeloperoxidase (MPO), catalase, prolidase were analyzed with kinetic spectrophotometric and thiol-disulphide, ischemia-modified albumin (IMA), ceruloplasmin were detected by colorimetric methods.Results: Serum levels of catalase [199.3 (16.4-489.9) vs 81.6 (18.2-322.9) (kU/L)], MPO [124±28 vs 101±31 U/L], disulphide [25 (11-61) vs 18 (2-41) µmol/L], IMA [0.66 (0.31-3.30) vs 0.62 (0.19-1.31) absorbance unit (ABSU)] and prolidase levels [2217±538 vs 1456±401 U/L] were higher in patients than control subjects (For all p&lt;0.001 except for IMA p=0.031). Native thiol [342±60 vs 391±52 µmol/L] and total thiol levels [396±56 vs 430±52 µmol/L] were lower in patients compared with the control group (For all p&lt;0.001).Conclusions: Levels of serum thiol/disulphide and prolidase might be reliable indicators for determining oxidative status in certain patient populations.</abstract>

Background: Oxidative damage is of great importance for patients with breast cancer. Thus, studies were performed to identify the relationship between breast cancer and oxidative stress biomarkers.Objectives: In this study, our aim was to find out the oxidative and antioxidant status, serum thiol-disulphide levels in subjects with breast cancer.Methods: This study was conducted between March and June 2018 with 82 control subjects (aged between 32-67 years) and 127 breast cancer patients (aged between 27-66 years) (p=0.058) in Selcuk University Faculty of Medicine, Konya, Turkey. Serum myeloperoxidase (MPO), catalase, prolidase were analyzed with kinetic spectrophotometric and thiol-disulphide, ischemia-modified albumin (IMA), ceruloplasmin were detected by colorimetric methods.Results: Serum levels of catalase [199.3 (16.4-489.9) vs 81.6 (18.2-322.9) (kU/L)], MPO [124±28 vs 101±31 U/L], disulphide [25 (11-61) vs 18 (2-41) µmol/L], IMA [0.66 (0.31-3.30) vs 0.62 (0.19-1.31) absorbance unit (ABSU)] and prolidase levels [2217±538 vs 1456±401 U/L] were higher in patients than control subjects (For all p<0.001 except for IMA p=0.031). Native thiol [342±60 vs 391±52 µmol/L] and total thiol levels [396±56 vs 430±52 µmol/L] were lower in patients compared with the control group (For all p<0.001).Conclusions: Levels of serum thiol/disulphide and prolidase might be reliable indicators for determining oxidative status in certain patient populations.

Assessment of Serum Ischemia-modified albumin, Prolidase and Thiol-Disulphide Levels in Subjects With Breast Cancer

Faculty of Medicine, Department of Biochemistry

Yildirim Beyazıt University Faculty of Medicine

Revista Romana de Medicina de Laborator

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Background: Oxidative damage is of great importance for patients with breast cancer. Thus, studies were performed to identify the relationship between breast...

Assessment of Serum Ischemia-modified albumin, Prolidase and Thiol-Disulphide Levels in Subjects With Breast Cancer

Published Online: Feb 01, 2019

Page range: 25 - 33

Received: Nov 01, 2018

Accepted: Jan 07, 2019

DOI: https://doi.org/10.2478/rrlm-2019-0013

Keywords
breast cancer, ischemia modified albumin, oxidative stress, prolidase, thiol-disulphide

© 2019 Sedat Abusoglu et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Assessment of Serum Ischemia-modified albumin, Prolidase and Thiol-Disulphide Levels in Subjects With Breast Cancer

Published Online: Feb 01, 2019

Page range: 25 - 33

Received: Nov 01, 2018

Accepted: Jan 07, 2019

DOI: https://doi.org/10.2478/rrlm-2019-0013

Keywordsbreast cancer, ischemia modified albumin, oxidative stress, prolidase, thiol-disulphide

© 2019 Sedat Abusoglu et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

Keywords
breast cancer, ischemia modified albumin, oxidative stress, prolidase, thiol-disulphide