[1. Wolkanin-Bartnik J, Pogorzelska H, Szperl M, Bartnik A, Koziarek J, Bilinska ZT. Impact of genetic and clinical factors on dose requirements and quality of anticoagulation therapy in Polish patients receiving acenocoumarol: dosing calculation algorithm. Pharmacogenet Genomics. 2013;23(11):611-8. DOI: 10.1097/ FPC.000000000000000410.1097/FPC.000000000000000424108193]Search in Google Scholar
[2. Daly AK. Pharmacogenomics of anticoagulants: steps toward personal dosage. Genome Med. 2009;1(1):10. DOI: 10.1186/gm1010.1186/gm10265158419348697]Search in Google Scholar
[3. Buzoianu AD, Trifa AP, Mureşanu DF, Crişan S. Analysis of CYP2C9*2, CYP2C9*3 and VKORC1 -1639 G>A polymorphisms in a population from South-Eastern Europe. J Cell Mol Med. 2012;16(12):2919-24. DOI: 10.1111/j.1582-4934.2012.01606.x10.1111/j.1582-4934.2012.01606.x439372022863573]Search in Google Scholar
[4. Thijssen HH, Flinois JP, Beaune PH. Cytochrome P4502C9 is the principal catalyst of racemic acenocoumarol hydroxylation reactions in human liver microsomes. Drug Metab Dispos. 2000;28(11):1284-90.]Search in Google Scholar
[5. Bodin L, Verstuyft C, Tregouet DA, Robert A, Dubert L, Funck-Brentano C, et al. Cytochrome P450 2C9 (CYP2C9) and vitamin K epoxide reductase (VKORC1) genotypes as determinants of acenocoumarol sensitivity. Blood. 2005;106(1):135-40. DOI: 10.1182/blood-2005-01-034110.1182/blood-2005-01-034115790782]Search in Google Scholar
[6. Pop TR, Vesa Ş, Trifa AP, Crişan S, Buzoianu AD. An acenocoumarol dose algorithm based on a South-Eastern European population. Eur J Clin Pharmacol. 2013;69(11):1901-7. DOI: 10.1007/s00228-013-1551-310.1007/s00228-013-1551-323774941]Search in Google Scholar
[7. Anton AI, Cerezo-Manchado JJ, Padilla J, Perez-Andreu V, Corral J, Vicente V, et al. Novel associations of VKORC1 variants with higher acenocoumarol requirements. PLoS One. 2013;8(5):e64469. DOI: 10.1371/ journal.pone.006446910.1371/journal.pone.0064469365688323691226]Search in Google Scholar
[8. Verhoef TI, Redekop WK, Buikema MM, Schalekamp T, Van Der Meer FJ, Le Cessie S, et al; EU-PACT Group. Long-term anticoagulant effects of the CYP2C9 and VKORC1 genotypes in acenocoumarol users. J Thromb Haemost. 2012;10(4):606-14. DOI: 10.1111/j.1538-7836.2012.04633.x10.1111/j.1538-7836.2012.04633.x22252093]Search in Google Scholar
[9. Kirchheiner J, Brockmöller J. Clinical consequences of cytochrome P4502C9 polymorphisms. Clin Pharmacol Ther. 2005;77(1):1-16. DOI: 10.1016/j. clpt.2004.08.009]Search in Google Scholar
[10. Geisen C, Watzka M, Sittinger K, Steffens M, Daugela L, Seifried E, et al. VKORC1 haplotypes and their impact on the inter individual and inter-ethnical variability of oral anticoagulation. Thromb Haemost. 2005;94(4):773-9.]Search in Google Scholar
[11. Montes R, de Gaona RE, Martinez-Gonzalez MA, Alberca I, Hermida J. The c._1639G4A polymorphism of the VKORC1 gene is a major determinant of the response to acenocoumarol in anticoagulated patients. Br J Haematol. 2006;133(2):183-187. DOI: 10.1111/j.1365-2141.2006.06007.x10.1111/j.1365-2141.2006.06007.x16611310]Search in Google Scholar
[12. Wen MS, Lee M, Chen JJ, Chuang HP, Lu LS, Chen CH, et al. Prospective study of warfarin dosage requirements based on CYP2C9 and VKORC1 genotypes. Clin Pharmacol Ther. 2008;84(1):83-9. DOI: 10.1038/ sj.clpt.610045310.1038/sj.clpt.610045318183038]Search in Google Scholar
[13. van Walraven C, Jennings A, Oake N, Fergusson D, Forster AJ. Effect of study setting on anticoagulation control: a systematic review and metaregression. Chest. 2006;129(5):1155-66. DOI: 10.1378/chest.129.5.115510.1378/chest.129.5.115516685005]Search in Google Scholar
[14. Spreafico M, Lodigiani C, van Leeuwen Y, Pizzotti D, Rota LL, Rosendaal F, et al. Effects of CYP2C9 and VKORC1 on INR variations and dose requirements during initial phase of anticoagulant therapy. Pharmacogenomics. 2008;9(9):1237-50. DOI: 10.2217/14622416.9.9.123710.2217/14622416.9.9.123718781852]Search in Google Scholar
[15. Teichert M, van Schaik RH, Hofman A, Uitterlinden AG, de Smet PA, Stricker BH, et al. Genotypes associated with reduced activity of VKORC1 and CYP2C9 and their modification of acenocoumarol anticoagulation during the initial treatment period. Clin Pharmacol Ther. 2009;85(4):379-86. DOI: 10.1038/clpt.2008.29410.1038/clpt.2008.29419225451]Search in Google Scholar
[16. Schalekamp T, Brassé BP, Roijers JFM, Chahid Y, van Geest-Daalderop JH, de Vries-Goldschmeding H, et al. VKORC1 and CYP2C9 genotypes and acenocoumarol anticoagulation status: Interaction between both genotypes affects overanticoagulation. Clin Pharmacol Ther. 2006;80(1):13-22. DOI: 10.1016/j.clpt.2006.04.00610.1016/j.clpt.2006.04.00616815313]Search in Google Scholar
[17. Limdi NA, Wiener H, Goldstein JA, Acton RT, Beasley TM. Influence of CYP2C9 and VKORC1 on Warfarin Response during Initiation of Therapy. Blood Cells Mol Dis. 2009;43(1):119-128. DOI: 10.1016/j. bcmd.2009.01.019]Search in Google Scholar
[18. Pérez-Andreu V1, Roldán V, Antón AI, García-Barberá N, Corral J, Vicente V, et al. Pharmacogenetic relevance of CYP4F2 V433M polymorphism on acenocoumarol therapy. Blood. 2009;113(20):4977-9. DOI: 10.1182/ blood-2008-09-176222 10.1182/blood-2008-09-17622219270263]Search in Google Scholar